Search Results - "Liu, Mira C P"

The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo by Sceneay, Jaclyn, Liu, Mira C P, Chen, Anna, Wong, Christina S F, Bowtell, David D L, Möller, Andreas

“…Intratumoral hypoxia is a poor prognostic factor associated with reduced disease-free survival in many cancer types, including breast cancer. Hypoxia…”
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CD73-Deficient Mice Are Resistant to Carcinogenesis by STAGG, John, BEAVIS, Paul A, DIVISEKERA, Upulie, LIU, Mira C. P, MÖLLER, Andreas, DARCY, Phillip K, SMYTH, Mark J

“…CD73 is a cell surface 5'-nucleotidase that converts AMP to adenosine, an immune suppressive molecule. CD73 may promote immune escape in cancer by contributing…”
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Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy by WONG, Christina S. F, SCENEAY, Jaclyn, CULLINANE, Carleen, BOWTELL, David D, MÖLLER, Andreas, HOUSE, Colin M, HALSE, Heloise M, LIU, Mira C. P, GEORGE, Joshy, POTDEVIN HUNNAM, Titaina C. U, PARKE, Belinda S, HAVIV, Izhak, RONAI, Ze'ev

“…Tumor hypoxia is associated with resistance to antiangiogenic therapy and poor prognosis. The Siah E3 ubiquitin ligases regulate the hypoxic response pathway…”
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Hemopoietic Stem Cells with Higher Hemopoietic Potential Reside at the Bone Marrow Endosteum by Haylock, David N., Williams, Brenda, Johnston, Hayley M., Liu, Mira C.P., Rutherford, Kate E., Whitty, Genevieve A., Simmons, Paul J., Bertoncello, Ivan, Nilsson, Susan K.

“…It is now evident that hemopoietic stem cells (HSC) are located in close proximity to bone lining cells within the endosteum. Accordingly, it is unlikely that…”
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The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression by Chan, Peter, Möller, Andreas, Liu, Mira C P, Sceneay, Jaclyn E, Wong, Christina S F, Waddell, Nic, Huang, Katie T, Dobrovic, Alexander, Millar, Ewan K A, O'Toole, Sandra A, McNeil, Catriona M, Sutherland, Robert L, Bowtell, David D, Fox, Stephen B

“…The seven in absentia homolog 2 (SIAH2) protein plays a significant role in the hypoxic response by regulating the abundance of hypoxia-inducible factor-α;…”
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Siah2-deficient mice show impaired skin wound repair by Musyoka, James N., Liu, Mira C.P., Pouniotis, Dodie S., Wong, Christina S.F., Bowtell, David D., Little, Peter J., Getachew, Robel, Möller, Andreas, Darby, Ian A.

“…Hypoxia is associated with the dermal wound healing process and hypoxia signaling is presumed to be crucial for normal wound repair. The Siah2 ubiquitin ligase…”
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The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer by Chen, Anna, Wong, Christina S F, Liu, Mira C P, House, Colin M, Sceneay, Jaclyn, Bowtell, David D, Thompson, Erik W, Möller, Andreas

“…Elucidating the mechanisms that underlie metastasis is of paramount importance to understanding tumor progression and to the development of novel therapeutics…”
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Genetic and epigenetic analysis of the TIMP-3 gene in ovarian cancer by Liu, Mira C.P, Choong, David Y.H, Hooi, Christine S.F, Williams, Louise H, Campbell, Ian G

“…Abstract Chromosome 22q shows a high frequency of loss of heterozygosity (LOH) in ovarian cancers suggesting the existence of one or more important tumor…”
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Loss of Siah2 does not impact angiogenic potential of murine endothelial cells by Wong, Christina S.F., Chen, Anna, Liu, Mira C.P., Parker, Belinda S., Möller, Andreas

“…Angiogenesis is triggered in response to hypoxia under many circumstances, from healthy cells and tissues during embryogenesis to pathological conditions like…”
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The DNMT3B C-->T promoter polymorphism and risk of breast cancer in a British population: a case-control study by Montgomery, Karen G, Liu, Mira C P, Eccles, Diana M, Campbell, Ian G

“…Gene promoter methylation is an important regulator of expression and is a key epigenetic factor in tumorigenesis. DNA methylation is mediated by DNA…”
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