Search Results - "Liu, Michael K. P."

Fitness Costs and Diversity of the Cytotoxic T Lymphocyte (CTL) Response Determine the Rate of CTL Escape during Acute and Chronic Phases of HIV Infection by GANUSOV, Vitaly V, GOONETILLEKE, Nilu, LIU, Michael K. P, FERRARI, Guido, SHAW, George M, MCMICHAEL, Andrew J, BORROW, Persephone, KORBER, Bette T, PERELSON, Alan S

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An Early HIV Mutation within an HLA-B57-Restricted T Cell Epitope Abrogates Binding to the Killer Inhibitory Receptor 3DL1 by BRACKENRIDGE, Simon, EVANS, Edward J, TOEBES, Mireille, GOONETILLEKE, Nilu, LIU, Michael K. P, DI GLERIA, Kati, SCHUMACHER, Ton N, DAVIS, Simon J, MCMICHAEL, Andrew J, GILLESPIE, Geraldine M

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Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection by Ferrari, Guido, Korber, Bette, Goonetilleke, Nilu, Liu, Michael K P, Turnbull, Emma L, Salazar-Gonzalez, Jesus F, Hawkins, Natalie, Self, Steve, Watson, Sydeaka, Betts, Michael R, Gay, Cynthia, McGhee, Kara, Pellegrino, Pierre, Williams, Ian, Tomaras, Georgia D, Haynes, Barton F, Gray, Clive M, Borrow, Persephone, Roederer, Mario, McMichael, Andrew J, Weinhold, Kent J

“…In the present study, we analyzed the functional profile of CD8+ T-cell responses directed against autologous transmitted/founder HIV-1 isolates during acute…”
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Differences in HIV-Specific T Cell Responses between HIV-Exposed and -Unexposed HIV-Seronegative Individuals by RITCHIE, Adam J, CAMPION, Suzanne L, LEGG, Kenneth, COHEN, Myron S, DELWART, Eric L, HAYNES, Barton F, FIDLER, Sarah, MCMICHAEL, Andrew J, GOONETILLEKE, Nilu, KOPYCINSKI, Jakub, MOODIE, Zoe, WANG, Z. Maggie, PANDYA, Kruti, MOORE, Stephen, LIU, Michael K. P, BRACKENRIDGE, Simon, KULDANEK, Kristin

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SARS-CoV-2 and HIV-1: Should HIV-1-Infected Individuals in Sub-Saharan Africa Be Considered a Priority Group for the COVID-19 Vaccines? by Mandala, Wilson Lewis, Liu, Michael K P

“…Since its emergence in 2019 SARS-CoV-2 has proven to have a higher level of morbidity and mortality compared to the other prevailing coronaviruses. Although…”
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The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection by Goonetilleke, Nilu, Liu, Michael K P, Salazar-Gonzalez, Jesus F, Ferrari, Guido, Giorgi, Elena, Ganusov, Vitaly V, Keele, Brandon F, Learn, Gerald H, Turnbull, Emma L, Salazar, Maria G, Weinhold, Kent J, Moore, Stephen, Letvin, Norman, Haynes, Barton F, Cohen, Myron S, Hraber, Peter, Bhattacharya, Tanmoy, Borrow, Persephone, Perelson, Alan S, Hahn, Beatrice H, Shaw, George M, Korber, Bette T, McMichael, Andrew J

“…Identification of the transmitted/founder virus makes possible, for the first time, a genome-wide analysis of host immune responses against the infecting HIV-1…”
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Exocytosis of CTLA-4 Is Dependent on Phospholipase D and ADP Ribosylation Factor-1 and Stimulated during Activation of Regulatory T Cells by Mead, Karen I, Zheng, Yong, Manzotti, Claire N, Perry, Laura C. A, Liu, Michael K. P, Burke, Fiona, Powner, Dale J, Wakelam, Michael J. O, Sansom, David M

“…CTLA-4 is an essential protein in the regulation of T cell responses that interacts with two ligands found on the surface of APCs (CD80 and CD86). CTLA-4 is…”
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Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection by Kramer, Holger B, Lavender, Kerry J, Qin, Li, Stacey, Andrea R, Liu, Michael K P, di Gleria, Katalin, Simmons, Alison, Gasper-Smith, Nancy, Haynes, Barton F, McMichael, Andrew J, Borrow, Persephone, Kessler, Benedikt M

“…The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or…”
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A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies by Liu, Donglai, Wang, Chu, Hora, Bhavna, Zuo, Tao, Goonetilleke, Nilu, Liu, Michael K P, Berrong, Mark, Ferrari, Guido, McMichael, Andrew J, Bhattacharya, Tanmoy, Perelson, Alan S, Gao, Feng

“…Mutations rapidly accumulate in the HIV-1 genome after infection. Some of those mutations are selected by host immune responses and often cause viral fitness…”
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Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus by Song, Hongshuo, Hora, Bhavna, Bhattacharya, Tanmoy, Goonetilleke, Nilu, Liu, Michael K P, Wiehe, Kevin, Li, Hui, Iyer, Shilpa S, McMichael, Andrew J, Perelson, Alan S, Gao, Feng

“…Immune escape mutations that revert back to the consensus sequence frequently occur in newly HIV-1-infected individuals and have been thought to render the…”
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Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection by Riou, Catherine, Ganusov, Vitaly V, Campion, Suzanne, Mlotshwa, Mandla, Liu, Michael K P, Whale, Victoria E, Goonetilleke, Nilu, Borrow, Persephone, Ferrari, Guido, Betts, Michael R, Haynes, Barton F, McMichael, Andrew J, Gray, Clive M

“…HIV infection is characterized by a gradual deterioration of immune function, mainly in the CD4 compartment. To better understand the dynamics of HIV-specific…”
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Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirus-specific CD8+ T cells by Riou, Catherine, Treurnicht, Florette, Abrahams, Melissa-Rose, Mlisana, Koleka, Liu, Michael K P, Goonetilleke, Nilu, Koup, Richard, Roederer, Mario, Abdool Karim, Salim, de Bruyn, Guy, Williamson, Carolyn, Gray, Clive M, Burgers, Wendy A

“…The generation of polyfunctional CD8(+) T cells, in response to vaccination or natural infection, has been associated with improved protective immunity…”
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Integration of CD28 and CTLA‐4 function results in differential responses of T cells to CD80 and CD86 by Manzotti, Claire N., Liu, Michael K. P., Burke, Fiona, Dussably, Laure, Zheng, Yong, Sansom, David M.

“…CD80 and CD86 have the capacity to either stimulate or inhibit T cell responses through their receptors CD28 and cytotoxic T lymphocyte‐associated antigen 4…”
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Vertical T cell immunodominance and epitope entropy determine HIV-1 escape by Liu, Michael K P, Hawkins, Natalie, Ritchie, Adam J, Ganusov, Vitaly V, Whale, Victoria, Brackenridge, Simon, Li, Hui, Pavlicek, Jeffrey W, Cai, Fangping, Rose-Abrahams, Melissa, Treurnicht, Florette, Hraber, Peter, Riou, Catherine, Gray, Clive, Ferrari, Guido, Tanner, Rachel, Ping, Li-Hua, Anderson, Jeffrey A, Swanstrom, Ronald, Cohen, Myron, Karim, Salim S Abdool, Haynes, Barton, Borrow, Persephone, Perelson, Alan S, Shaw, George M, Hahn, Beatrice H, Williamson, Carolyn, Korber, Bette T, Gao, Feng, Self, Steve, McMichael, Andrew, Goonetilleke, Nilu

“…HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8+ T cells. Measurements of HIV-1 time to escape should…”
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HLA-E-restricted, Gag-specific CD8 + T cells can suppress HIV-1 infection, offering vaccine opportunities by Yang, Hongbing, Rei, Margarida, Brackenridge, Simon, Brenna, Elena, Sun, Hong, Abdulhaqq, Shaheed, Liu, Michael K P, Ma, Weiwei, Kurupati, Prathiba, Xu, Xiaoning, Cerundolo, Vincenzo, Jenkins, Edward, Davis, Simon J, Sacha, Jonah B, Früh, Klaus, Picker, Louis J, Borrow, Persephone, Gillespie, Geraldine M, McMichael, Andrew J

“…Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cells and T…”
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Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection by Peng, Binghao J, Carlson, Jonathan M, Liu, Michael K P, Gao, Feng, Goonetilleke, Nilu, McMichael, Andrew J, Borrow, Persephone, Gilmour, Jill, Heath, Sonya L, Hunter, Eric, Bansal, Anju, Goepfert, Paul A

“…While prior studies have demonstrated that CD8 T cell responses to cryptic epitopes (CE) are readily detectable during HIV-1 infection, their ability to drive…”
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Diagnostic accuracy and clinical utility of a simplified low cost method of counting CD4 cells with flow cytometry in Malawi: diagnostic accuracy study by MacLennan, Calman A, Liu, Michael K P, White, Sarah A, van Oosterhout, Joep J G, Simukonda, Felanji, Bwanali, Joseph, Moore, Michael J, Zijlstra, Eduard E, Drayson, Mark T, Molyneux, Malcolm E

“…Objectives To assess the diagnostic accuracy and clinical utility of a simplified low cost method for measuring absolute and percentage CD4 counts with flow…”
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Reversion and T Cell Escape Mutations Compensate the Fitness Loss of a CD8.sup.+ T Cell Escape Mutant in Their Cognate Transmitted/Founder Virus by Song, Hongshuo, Hora, Bhavna, Bhattacharya, Tanmoy, Goonetilleke, Nilu, Liu, Michael K. P, Wiehe, Kevin, Li, Hui, Iyer, Shilpa S, McMichael, Andrew J, Perelson, Alan S, Gao, Feng

“…Immune escape mutations that revert back to the consensus sequence frequently occur in newly HIV-1-infected individuals and have been thought to render the…”
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Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome by Song, Hongshuo, Pavlicek, Jeffrey W, Cai, Fangping, Bhattacharya, Tanmoy, Li, Hui, Iyer, Shilpa S, Bar, Katharine J, Decker, Julie M, Goonetilleke, Nilu, Liu, Michael K P, Berg, Anna, Hora, Bhavna, Drinker, Mark S, Eudailey, Josh, Pickeral, Joy, Moody, M Anthony, Ferrari, Guido, McMichael, Andrew, Perelson, Alan S, Shaw, George M, Hahn, Beatrice H, Haynes, Barton F, Gao, Feng

“…A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To…”
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Elevation of Intact and Proteolytic Fragments of Acute Phase Proteins Constitutes the Earliest Systemic Antiviral Response in HIV-1 Infection: e1000893 by Kramer, Holger B, Lavender, Kerry J, Qin, Li, Stacey, Andrea R, Liu, Michael KP, Gleria, Katalin di, Simmons, Alison, Gasper-Smith, Nancy, Haynes, Barton F, McMichael, Andrew J, Borrow, Persephone, Kessler, Benedikt M

“…The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or…”
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