Search Results - "Liu, Meizheng"
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Design of Novel Antibiotics that Bind to the Ribosomal Acyltransfer Site
Published in Journal of the American Chemical Society (03-04-2002)“…The structure of neamine bound to the A site of the bacterial ribosomal RNA was used in the design of novel aminoglycosides. The design took into account…”
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高效液相色谱法分离和分析喷妥司汀及其异构体
Published in Fēnxī huàxué (2006)“…利用高效液相色谱方法在普通Polar-RP柱上成功分离pentostatin的4个异构体。通过考察色谱柱、流动相、温度等对分离度的影响,得到最佳分离条件为:室温下以Phenomenex Synergi…”
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An exploratory study of metformin (Met) with or without rapamycin (Rapa) as maintenance therapy after induction chemotherapy in patients (Pts) with metastatic pancreatic adenocarcinoma (PDA)
Published in Journal of clinical oncology (01-02-2020)“…Abstract only 700 Background: Few studies have examined maintenance therapy in unselected pts with metastatic PDA (mPDA). mTOR signaling is central to several…”
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A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint
Published in Clinical epigenetics (02-02-2021)“…Epigenetic therapies may modulate the tumor microenvironment. We evaluated the safety and optimal sequence of combination DNA methyltransferase inhibitor…”
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An exploratory study of metformin with or without rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic adenocarcinoma
Published in Oncotarget (26-05-2020)“…PURPOSEMetformin combined with the mTOR inhibitor rapamycin showed potential synergistic anti-tumor activity in preclinical studies in pancreatic ductal…”
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First total synthesis of 25(R)-ruscogenin-1-yl β-D-xylopyranosyl-(1→3)-[β-D-glucopyranosyl-(1→2)]-β-D-fucopyranoside, an ophiopogonis saponin from the tuber of Liriope muscari (Decne.)
Published in Tetrahedron letters (1998)“…The first total synthesis of 25(R)-ruscogenin-1-yl β-D-xylopyranosyl-(1→3)-[β-D-glucopyranosyl-(1→2)]-β-D-fucopyranoside ( 1), an Ophiopogonis saponin with…”
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7
Tethered Bisubstrate Derivatives as Probes for Mechanism and as Inhibitors of Aminoglycoside 3‘-Phosphotransferases
Published in Journal of organic chemistry (03-11-2000)“…Aminoglycoside 3‘-phosphotransferases [APH(3‘)s] phosphorylate aminoglycoside antibiotics, a reaction that inactivates the antibiotics. These enzymes are the…”
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Synthesis of diosgenyl α- l-rhamnopyranosyl-(1→2)-[ β- d-glucopyranosyl-(1→3)]- β- d-glucopyranoside (gracillin) and related saponins
Published in Carbohydrate research (1998)“…Diosgenyl α- l-rhamnopyranosyl-(1→2)-[ β- d-glucopyranosyl-(1→3)]- β- d-glucopyranoside (gracillin), a monodesmosidic saponin isolated from paris, dioscorea,…”
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Synthesis of (25 R)-ruscogenin-1-yl β- d-xylopyranosyl-(1→3)-[β- d-glucopyranosyl-(1→2)]-β- d-fucopyranoside
Published in Carbohydrate research (01-12-2000)“…The synthesis of (25 R)-ruscogenin-1-yl β- d-xylopyranosyl-(1→3)-[β- d-glucopyranosyl-(1→2)]-β- d-fucopyranoside, a saponin from the tuber of Liriope muscari…”
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