Search Results - "Liu, Manchang"

The Local and Systemic Inflammatory Transcriptome after Acute Kidney Injury by GRIGORYEV, Dmitry N, MANCHANG LIU, HASSOUN, Heitham T, CHEADLE, Chris, BARNES, Kathleen C, RABB, Hamid

“…Studies in humans and animal models have demonstrated that acute kidney injury (AKI) has a significant effect on the function of extrarenal organs. The…”
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Acute Kidney Injury Leads to Inflammation and Functional Changes in the Brain by MANCHANG LIU, YIDENG LIANG, CHIGURUPATI, Srinivasulu, LATHIA, Justin D, PLETNIKOV, Mikhail, ZHAOLI SUN, CROW, Michael, ROSS, Christopher A, MATTSON, Mark P, RABB, Hamid

“…Although neurologic sequelae of acute kidney injury (AKI) are well described, the pathogenesis of acute uremic encephalopathy is poorly understood. This study…”
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Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice by Liu, Manchang, Grigoryev, Dmitry N., Crow, Michael T., Haas, Mark, Yamamoto, Masayuki, Reddy, Sekhar P., Rabb, Hamid

“…Oxidative stress is involved in acute kidney injury due to ischemia–reperfusion and chemotherapy-induced nephrotoxicity. To investigate their basic mechanisms…”
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Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes by Ascon, Miguel, Ascon, Dolores B., Liu, Manchang, Cheadle, Chris, Sarkar, Chaitali, Racusen, Lorraine, Hassoun, Heitham T., Rabb, Hamid

“…It is well-established that significant ischemia-reperfusion injury during kidney transplantation results in increased incidence of long-term fibrosis and…”
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The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice by Liu, Manchang, Reddy, Narsa M, Higbee, Elizabeth M, Potteti, Haranatha R, Noel, Sanjeev, Racusen, Lorraine, Kensler, Thomas W, Sporn, Michael B, Reddy, Sekhar P, Rabb, Hamid

“…Acute kidney injury (AKI) caused by ischemia-reperfusion is a major clinical problem in both native and transplanted kidneys. We had previously shown that…”
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Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis by Hassoun, Heitham T, Lie, Mihaela L, Grigoryev, Dmitry N, Liu, Manchang, Tuder, Rubin M, Rabb, Hamid

“…Distant organ effects of acute kidney injury (AKI) are a leading cause of morbidity and mortality. While little is known about the underlying mechanisms,…”
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Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy by Hassoun, Heitham T, Grigoryev, Dmitry N, Lie, Mihaela L, Liu, Manchang, Cheadle, Chris, Tuder, Rubin M, Rabb, Hamid

“…Acute kidney injury (AKI) is associated with significant mortality, which increases further when combined with acute lung injury. Experiments in rodents have…”
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A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity by MANCHANG LIU, CHIEN, Chu-Chun, BURNE-TANEY, Melissa, MOLLS, Roshni R, RACUSEN, Lorraine C, COLVIN, Robert B, RABB, Hamid

“…Recent evidence supports a role for an inflammatory pathogenesis of cisplatin nephrotoxicity, but immune cell-mediated mechanisms in this disease are still…”
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Phenotypic and Functional Characterization of Kidney-Infiltrating Lymphocytes in Renal Ischemia Reperfusion Injury by Ascon, Dolores B, Lopez-Briones, Sergio, Liu, Manchang, Ascon, Miguel, Savransky, Vladimir, Colvin, Robert B, Soloski, Mark J, Rabb, Hamid

“…T and B lymphocytes have been implicated in the pathogenesis of renal ischemia reperfusion injury (IRI). The trafficking of lymphocytes into kidneys during IRI…”
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Blocking Fas Ligand on Leukocytes Attenuates Kidney Ischemia-Reperfusion Injury by GANG JEE KO, HYE RYOUN JANG, RABB, Hamid, YANFEI HUANG, WOMER, Karl L, MANCHANG LIU, HIGBEE, Elizabeth, ZUOXIANG XIAO, YAGITA, Hideo, RACUSEN, Lorraine, HAMAD, Abdel Rahim A

“…Inflammation contributes to the pathogenesis of ischemic acute kidney injury (AKI), and T cells mediate the early phase of ischemia-reperfusion injury (IRI)…”
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Non‐dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients by Liu, Manchang, Takahashi, Hiroshi, Morita, Yoshiki, Maruyama, Shoichi, Mizuno, Masashi, Yuzawa, Yukio, Watanabe, Midoriko, Toriyama, Takanobu, Kawahara, Hirohisa, Matsuo, Seiichi

“…Background. Lack of nocturnal blood pressure (BP) fall (non‐dipping) is common among haemodialysis (HD) patients, but much less is known regarding its…”
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Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury by Molls, Roshni R, Savransky, Vladimir, Liu, Manchang, Bevans, Shannon, Mehta, Tulsi, Tuder, Rubin M, King, Landon S, Rabb, Hamid

“…Renal ischemia-reperfusion injury (IRI) is the leading cause of acute kidney injury [AKI; acute renal failure (ARF)] in native kidneys and delayed graft…”
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Decreased Capacity of Immune Cells to Cause Tissue Injury Mediates Kidney Ischemic Preconditioning by Burne-Taney, Melissa J, Liu, Manchang, Baldwin, William M, Racusen, Lorraine, Rabb, Hamid

“…Ischemic preconditioning (IP) is a well-established phenomenon, and the underlying mechanisms of IP are thought to involve adaptive changes within the injured…”
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Ischemic acute kidney injury (AKI) induces caspase-dependent pulmonary endothelial apoptosis which contributes to AKI-associated lung injury by Hassoun, Heitham, MD, Lie, Mihaela, MD, Grigoryev, Dmitry, MD, PhD, Liu, Manchang, MD, PhD, Tuder, Rubin, MD, Rabb, Hamid, MD

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Uremic lung: new insights into a forgotten condition by Scheel, Paul J., Liu, Manchang, Rabb, Hamid

“…The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ…”
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Acute renal venous obstruction is more detrimental to the kidney than arterial occlusion: implication for murine models of acute kidney injury by Li, Xiang, Liu, Manchang, Bedja, Djahida, Thoburn, Christopher, Gabrielson, Kathleen, Racusen, Lorraine, Rabb, Hamid

“…In this study, we compared the traditional murine model with renal pedicle clamp with models that clamped the renal artery or vein alone as well as to a whole…”
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The Role for T Cell Repertoire/Antigen-Specific Interactions in Experimental Kidney Ischemia Reperfusion Injury by Satpute, Shailesh Ramchandra, Park, Jong Myun, Jang, Hye Ryoun, Agreda, Patricia, Liu, Manchang, Gandolfo, Maria Teresa, Racusen, Lorraine, Rabb, Hamid

“…T cells have been implicated in the early pathogenesis of ischemia reperfusion injury (IRI) of kidney, liver, lung, and brain. It is not known whether Ag-TCR…”
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Transcriptional analysis of infiltrating T cells in kidney ischemia-reperfusion injury reveals a pathophysiological role for CCR5 by Ko, Gang Jee, Linfert, Douglas, Jang, Hye Ryoun, Higbee, Elizabeth, Watkins, Tonya, Cheadle, Chris, Liu, Manchang, Racusen, Lorraine, Grigoryev, Dmitry N, Rabb, Hamid

“…Although T cells have been shown to play a direct role in kidney ischemia-reperfusion injury (IRI), little is known about the underlying mechanisms. We…”
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Transfer of lymphocytes from mice with renal ischemia can induce albuminuria in naive mice: a possible mechanism linking early injury and progressive renal disease? by Burne-Taney, Melissa J, Liu, Manchang, Ascon, Dolores, Molls, Roshni R, Racusen, Lorraine, Rabb, Hamid

“…Severe ischemia-reperfusion injury (IRI) predisposes to long-term impairment in kidney function both in patients and experimentally through unknown mechanisms…”
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Effect of T cells on vascular permeability in early ischemic acute kidney injury in mice by Liu, Manchang, Chien, Chu-Chun, Grigoryev, Dmitry N., Gandolfo, Maria Teresa, Colvin, Robert B., Rabb, Hamid

“…Although previous studies have demonstrated that microvascular dysfunction and inflammation occur in ischemia–reperfusion injury (IRI), the underlying…”
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