Dietary Supplementation with Silicon-Enriched Spirulina Improves Arterial Remodeling and Function in Hypertensive Rats

Vascular aging is characterized by increase in arterial stiffness and remodeling of the arterial wall with a loss of elastic properties. Silicon is an essential trace element highly present in arteries. It is involved in the constitution and stabilization of elastin fibers. The nutritional supply an...

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Bibliographic Details
Published in:	Nutrients Vol. 11; no. 11; p. 2574
Main Authors:	Arthur-Ataam, Joanna, Bideaux, Patrice, Charrabi, Azzouz, Sicard, Pierre, Fromy, Bérengère, Liu, Kiaoling, Eddahibi, Saadia, Pasqualin, Côme, Jouy, Nicolas, Richard, Sylvain, Virsolvy, Anne
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 25-10-2019 MDPI
Subjects:	Aging Aorta arterial structure Atherosclerosis Bioavailability Blood pressure Cardiology and cardiovascular system Contractility Coronary vessels Depolarization Dietary supplements Elastin Food Food and Nutrition Food sources Human health and pathology Hypertension Laboratory animals Life Sciences Nutrient deficiency Nutrients Nutritional status Potassium chloride Silicon spirulina Structure-function relationships Trace elements vascular function France vascular function silicon arterial structure spirulina hypertension
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Summary:	Vascular aging is characterized by increase in arterial stiffness and remodeling of the arterial wall with a loss of elastic properties. Silicon is an essential trace element highly present in arteries. It is involved in the constitution and stabilization of elastin fibers. The nutritional supply and bioavailability of silicon are often inadequate. Spirulina (Sp), micro algae have recognized nutritional properties and are able to incorporate minerals in a bioavailable form. We evaluated the effects of nutritional supplementation with silicon-enriched spirulina (SpSi) on arterial system structure and function in hypertension. Experiments were performed on hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats supplemented with SpSi or Sp over a period of three months. Arterial pressure, vascular function and morphometric parameters of thoracic aorta were analyzed. SpSi supplementation lowered arterial pressure in SHR and minimized morphometric alterations induced by hypertension. Aortic wall thickness and elastic fibers fragmentation were partially reversed. Collagen and elastin levels were increased in association with extracellular matrix degradation decrease. Vascular reactivity was improved with better contractile and vasorelaxant responses to various agonists. No changes were observed in SHR supplemented with Sp. The beneficial effects of SpSi supplementation evidenced here, may be attributable to Si enrichment and offer interesting opportunities to prevent cardiovascular risks.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 PMCID: PMC6893466
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu11112574