Search Results - "Liu, Kathy"

Can we learn lessons from the FDA’s approval of aducanumab? by Liu, Kathy Y., Howard, Robert

“…On 7 June 2021, aducanumab was granted accelerated approval for the treatment of Alzheimer disease (AD) by the FDA on the basis of amyloid-lowering effects…”
Get full text

Questions EMERGE as Biogen claims aducanumab turnaround by Howard, Robert, Liu, Kathy Y.

“…Trials of aducanumab in Alzheimer disease were previously discontinued following a phase III futility analysis, but Biogen now says that additional data…”
Get full text

The chemical diversity of RNA modifications by Ontiveros, R Jordan, Stoute, Julian, Liu, Kathy Fange

“…Nucleic acid modifications in DNA and RNA ubiquitously exist among all the three kingdoms of life. This trait significantly broadens the genome diversity and…”
Get more information

An Electrochemical Gelation Method for Patterning Conductive PEDOT:PSS Hydrogels by Feig, Vivian Rachel, Tran, Helen, Lee, Minah, Liu, Kathy, Huang, Zhuojun, Beker, Levent, Mackanic, David G., Bao, Zhenan

“…Due to their high water content and macroscopic connectivity, hydrogels made from the conducting polymer PEDOT:PSS are a promising platform from which to…”
Get full text

The Role of Mathematics Teaching in Fostering Student Growth Mindset by Sun, Kathy Liu

“…The belief that mathematics ability is a fixed trait is particularly common and may be a key reason for many students' disinterest and underperformance in…”
Get full text

Magnetic resonance imaging of the human locus coeruleus: A systematic review by Liu, Kathy Y., Marijatta, Freya, Hämmerer, Dorothea, Acosta-Cabronero, Julio, Düzel, Emrah, Howard, Robert J.

“…•Magnetic resonance imaging studies of the human locus coeruleus (LC) are reviewed.•The methodology and outcomes for 69 structural and functional studies are…”
Get full text

The need to show minimum clinically important differences in Alzheimer's disease trials by Liu, Kathy Y, Schneider, Lon S, Howard, Robert

“…Deciding on the smallest change in an outcome that constitutes a clinically meaningful treatment effect (ie, the minimum clinically important difference…”
Get full text

Heart rate variability in relation to cognition and behavior in neurodegenerative diseases: A systematic review and meta-analysis by Liu, Kathy Y., Elliott, Thomas, Knowles, Melanie, Howard, Robert

“…Neurodegenerative diseases, which frequently present with neuropsychiatric symptoms related to prefrontal cortical dysfunction, can alter the integrity of the…”
Get full text

Clinical utility of cerebrospinal fluid biomarkers in the evaluation of cognitive impairment: a systematic review and meta-analysis by Hazan, Jemma, Wing, Michelle, Liu, Kathy Y, Reeves, Suzanne, Howard, Robert

“…BackgroundThe analytical and clinical validity of cerebrospinal (CSF) biomarkers has been extensively researched in dementia. Further work is needed to assess…”
Get full text

How can secondary dementia prevention trials of Alzheimer's disease be clinically meaningful? by Liu, Kathy Y., Thambisetty, Madhav, Howard, Robert

“…After clinical trial failures in symptomatic Alzheimer's disease (AD), our field has moved to earlier intervention in cognitively normal individuals with…”
Get full text

Pimavanserin and dementia-related psychosis: can HARMONY prevail? by Liu, Kathy Y, Howard, Robert

“…Delusions and hallucinations are common in people with dementia,1 and although risperidone and olanzapine show efficacy for the treatment of psychosis in…”
Get full text

Heart rate variability, electrodermal activity and cognition in adults: Association with short-term indoor PM2.5 exposure in a real-world intervention study by Zhou, Jiaxu, Huebner, Gesche, Liu, Kathy Y., Ucci, Marcella

“…Long-term effects of ambient fine particulate matter (PM2.5) exposure on mortality and morbidity are well established. The study aims to evaluate how…”
Get full text

In vivo visualization of age-related differences in the locus coeruleus by Liu, Kathy Y., Acosta-Cabronero, Julio, Cardenas-Blanco, Arturo, Loane, Clare, Berry, Alex J., Betts, Matthew J., Kievit, Rogier A., Henson, Richard N., Düzel, Emrah, Howard, Robert, Hämmerer, Dorothea

“…The locus coeruleus (LC), the major origin of noradrenergic modulation of the central nervous system, may play an important role in neuropsychiatric disorders…”
Get full text

Has COVID‐19 affected dementia diagnosis rates in England? by Hazan, Jemma, Liu, Kathy Y., Isaacs, Jeremy D., Burns, Alistair, Howard, Robert

“…Background The COVID‐19 pandemic impacted on the provision of care and routine activity of all National Health Service (NHS) services. While General…”
Get full text

Challenges in a Biological Definition of Alzheimer Disease by Hazan, Jemma, Liu, Kathy Y, Costello, Harry, Isaacs, Jeremy D, Thambisetty, Madhav, Howard, Robert

“…It has been suggested that the diagnostic landscape of Alzheimer disease (AD) is undergoing a profound transformation, marked by a shift toward a…”
Get full text

Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer’s disease: systematic review and meta-analysis by David, Michael C B, Del Giovane, Martina, Liu, Kathy Y, Gostick, Benjamin, Rowe, James Benedict, Oboh, Imafidon, Howard, Robert, Malhotra, Paresh A

“…BackgroundDysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease, contributing to cognitive and neuropsychiatric symptoms…”
Get full text

Dementia diagnosis rates and the impact of ethnicity, rurality and deprivation by Hazan, Jemma, Liu, Kathy Y, Isaacs, Jeremy D, Mukadam, Naaheed

“…NHS England publishes monthly national and regional estimated dementia diagnosis rates (DDR) to assess the healthcare system's effectiveness in identifying…”
Get full text

Dementia wellbeing and COVID‐19: Review and expert consensus on current research and knowledge gaps by Liu, Kathy Y., Howard, Robert, Banerjee, Sube, Comas‐Herrera, Adelina, Goddard, Joanne, Knapp, Martin, Livingston, Gill, Manthorpe, Jill, O'Brien, John T., Paterson, Ross W., Robinson, Louise, Rossor, Martin, Rowe, James B., Sharp, David J., Sommerlad, Andrew, Suárez‐González, Aida, Burns, Alistair

“…Objectives In response to a commissioned research update on dementia during the COVID‐19 pandemic, a UK‐based working group, comprising dementia researchers…”
Get full text

Personality disorders and suicide in China by Liu, Kathy Y

“…The theory and diagnosis of mental illnesses, including personality disorders, occur within prevailing cultural expectations. 2 While the cultural differences…”
Get full text

Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation by Bates, Jamie, Vijayakumar, Archana, Ghoshal, Sarani, Marchand, Bruno, Yi, Saili, Kornyeyev, Dmytro, Zagorska, Anna, Hollenback, David, Walker, Katie, Liu, Kathy, Pendem, Swetha, Newstrom, David, Brockett, Robert, Mikaelian, Igor, Kusam, Saritha, Ramirez, Ricardo, Lopez, David, Li, Li, Fuchs, Bryan C., Breckenridge, David G.

“…Non-alcoholic steatohepatitis (NASH) is a chronic liver disease characterized by hepatic lipid accumulation, inflammation, and progressive fibrosis. Acetyl-CoA…”
Get full text