Search Results - "Liu, Julia C."

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing by Paek, Andrew L., Liu, Julia C., Loewer, Alexander, Forrester, William C., Lahav, Galit

“…Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We used live-cell imaging to investigate the role of p53 dynamics in…”
Get full text

Bacterial adaptation through loss of function by Hottes, Alison K, Freddolino, Peter L, Khare, Anupama, Donnell, Zachary N, Liu, Julia C, Tavazoie, Saeed

“…The metabolic capabilities and regulatory networks of bacteria have been optimized by evolution in response to selective pressures present in each species'…”
Get full text

High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis by Liu, Julia C., Guan, Xiao, Ryan, Jeremy A., Rivera, Ana G., Mock, Caroline, Agarwal, Vishesh, Letai, Anthony, Lerou, Paul H., Lahav, Galit

“…Human embryonic stem cells (hESCs) are highly sensitive to DNA damage and have low survival ability relative to differentiated cells. We investigated the…”
Get full text

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload by Liu, Julia C., Liu, Jie, Holmström, Kira M., Menazza, Sara, Parks, Randi J., Fergusson, Maria M., Yu, Zu-Xi, Springer, Danielle A., Halsey, Charles, Liu, Chengyu, Murphy, Elizabeth, Finkel, Toren

“…MICU1 is a component of the mitochondrial calcium uniporter, a multiprotein complex that also includes MICU2, MCU, and EMRE. Here, we describe a mouse model of…”
Get full text

Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter by Holmström, Kira M, Pan, Xin, Liu, Julia C, Menazza, Sara, Liu, Jie, Nguyen, Tiffany T, Pan, Haihui, Parks, Randi J, Anderson, Stasia, Noguchi, Audrey, Springer, Danielle, Murphy, Elizabeth, Finkel, Toren

“…Abstract Mitochondrial calcium is thought to play an important role in the regulation of cardiac bioenergetics and function. The entry of calcium into the…”
Get full text

Mitochondrial calcium and reactive oxygen species in cardiovascular disease by Murphy, Elizabeth, Liu, Julia C

“…Abstract Cardiomyocytes are one of the most mitochondria-rich cell types in the body, with ∼30–40% of the cell volume being composed of mitochondria…”
Get full text

The In Vivo Biology of the Mitochondrial Calcium Uniporter by Liu, Julia C, Parks, Randi J, Liu, Jie, Stares, Justin, Rovira, Ilsa I, Murphy, Elizabeth, Finkel, Toren

“…The identification of the molecular composition of the mitochondrial calcium uniporter has allowed for the genetic manipulation of its components and the…”
Get more information

Is MCU dispensable for normal heart function? by Liu, Julia C.

“…The uptake of Ca2+ into mitochondria is thought to be an important signal communicating the need for increased energy production. However, dysregulated uptake…”
Get full text

MICUs protect the heart by regulating mitochondrial calcium by Ozkurede, Ulas, Pakkiriswami, Shanmugasundaram, Liu, Julia C.

“…Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al…”
Get full text

Stem cells: balancing resistance and sensitivity to DNA damage by Liu, Julia C, Lerou, Paul H, Lahav, Galit

“…Highlights • ESCs are highly sensitive to DNA damage whereas adult stem cells vary in sensitivity. • Multiple mechanisms affect the sensitivity of stem cells…”
Get full text

MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy by Roman, Barbara, Mastoor, Yusuf, Sun, Junhui, Chapoy Villanueva, Hector, Hinojosa, Gabriela, Springer, Danielle, Liu, Julia C, Murphy, Elizabeth

“…Calcium (Ca ) uptake by mitochondria occurs via the mitochondrial Ca uniporter. Mitochondrial Ca uniporter exists as a complex, regulated by 3 MICU…”
Get full text

Mitochondrial Permeability Transition Pore and Calcium Handling by Parks, Randi J, Murphy, Elizabeth, Liu, Julia C

“…The opening of a large conductance channel in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore (PTP), has been shown…”
Get more information

Ventricular differences in mitochondrial Ca2+ dynamics in murine and porcine hearts by Sung, Jae Hwi, Chapoy Villanueva, Hector, Feng, Feng, Araque Igualador, Ariadna, Prins, Kurt W., Liu, Julia C.

Get full text

Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response by Porter, Joshua R., Fisher, Brian E., Baranello, Laura, Liu, Julia C., Kambach, Diane M., Nie, Zuqin, Koh, Woo Seuk, Luo, Ji, Stommel, Jayne M., Levens, David, Batchelor, Eric

“…In response to stresses, cells often halt normal cellular processes, yet stress-specific pathways must bypass such inhibition to generate effective responses…”
Get full text

Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term by Chapoy Villanueva, Hector, Sung, Jae Hwi, Stevens, Jackie A., Zhang, Michael J., Nelson, Peyton M., Denduluri, Lalitha S., Feng, Feng, O'Connell, Timothy D., Townsend, DeWayne, Liu, Julia C.

“…Transport of Ca2+ into mitochondria is thought to stimulate the production of ATP, a critical process in the heart's fight or flight response, but excess Ca2+…”
Get full text

Mechanisms of reduced myocardial energetics of the dystrophic heart by Stevens, Jackie A, Dobratz, Tyler C, Fischer, Kaleb D, Palmer, Alexandria, Bourdage, Kira, Wong, Anne J, Chapoy-Villanueva, Hector, Garry, Daniel J, Liu, Julia C, Kay, Matthew W, Kuzmiak-Glancy, Sarah, Townsend, DeWayne

“…Heart disease is a leading cause of death in patients with Duchenne muscular dystrophy (DMD), characterized by the progressive replacement of contractile…”
Get more information

MICU3 Plays an Important Role in Cardiovascular Function by Puente, Bao N., Sun, Junhui, Parks, Randi J., Fergusson, Maria M., Liu, Chengyu, Springer, Danielle A., Aponte, Angel M., Liu, Julia C., Murphy, Elizabeth

Get full text

Modifying a sealed tube zinc reduction method for preparation of AMS graphite targets: Reducing background and attaining high precision by Xu, Xiaomei, Trumbore, Susan E., Zheng, Shuhui, Southon, John R., McDuffee, Kelsey E., Luttgen, Madelyn, Liu, Julia C.

“…The sealed tube zinc reduction method for converting CO2 to graphite for AMS 14C measurements was originally developed for rapid production of graphite in…”
Get full text

EMRE is essential for mitochondrial calcium uniporter activity in a mouse model by Liu, Julia C, Syder, Nicole C, Ghorashi, Nima S, Willingham, Thomas B, Parks, Randi J, Sun, Junhui, Fergusson, Maria M, Liu, Jie, Holmström, Kira M, Menazza, Sara, Springer, Danielle A, Liu, Chengyu, Glancy, Brian, Finkel, Toren, Murphy, Elizabeth

“…The mitochondrial calcium uniporter is widely accepted as the primary route of rapid calcium entry into mitochondria, where increases in matrix calcium…”
Get full text

High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis by Liu, Julia C., Guan, Xiao, Ryan, Jeremy A., Rivera, Ana G., Mock, Caroline, Agrawal, Vishesh, Letai, Anthony, Lerou, Paul H., Lahav, Galit

Get full text