Search Results - "Liu, Jonathan T.C."

Identification of Cell Surface Targets through Meta-analysis of Microarray Data by Haeberle, Henry, Dudley, Joel T, Liu, Jonathan T.C, Butte, Atul J, Contag, Christopher H

“…Abstract High-resolution image guidance for resection of residual tumor cells would enable more precise and complete excision for more effective treatment of…”
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Trends in Fluorescence Image-Guided Surgery for Gliomas by Liu, Jonathan T.C., Meza, Daphne, Sanai, Nader

“…Abstract Mounting evidence suggests that a more extensive surgical resection is associated with an improved life expectancy for both low-grade and high-grade…”
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Nondestructive 3D Pathology with Light-Sheet Fluorescence Microscopy for Translational Research and Clinical Assays by Liu, Jonathan T.C, Glaser, Adam K, Poudel, Chetan, Vaughan, Joshua C

“…In recent years, there has been a revived appreciation for the importance of spatial context and morphological phenotypes for both understanding disease…”
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Microdissected "cuboids" for microfluidic drug testing of intact tissues by Horowitz, Lisa F, Rodriguez, Adan D, Au-Yeung, Allan, Bishop, Kevin W, Barner, Lindsey A, Mishra, Gargi, Raman, Aashik, Delgado, Priscilla, Liu, Jonathan T C, Gujral, Taranjit S, Mehrabi, Mehdi, Yang, Mengsu, Pierce, Robert H, Folch, Albert

“…As preclinical animal tests often do not accurately predict drug effects later observed in humans, most drugs under development fail to reach the market. Thus…”
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Nondestructive 3D Pathology Image Atlas of Barrett Esophagus With Open-Top Light-Sheet Microscopy by Reddi, Deepti M, Barner, Lindsey A, Burke, Wynn, Gao, Gan, Grady, William M, Liu, Jonathan T C

“…Anatomic pathologists render diagnosis on tissue samples sectioned onto glass slides and viewed under a bright-field microscope. This approach is destructive…”
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Reaction-Driven Nucleation Theory by Wall, Matthew A, Cossairt, Brandi M, Liu, Jonathan T. C

“…Understanding how nucleation is driven by chemical reactions is essential for the optimal design of materials grown from molecular precursors. Typically, the…”
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In vivo multiplexed molecular imaging of esophageal cancer via spectral endoscopy of topically applied SERS nanoparticles by Wang, Yu Winston, Kang, Soyoung, Khan, Altaz, Bao, Philip Q, Liu, Jonathan T C

“…The biological investigation and detection of esophageal cancers could be facilitated with an endoscopic technology to screen for the molecular changes that…”
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FalseColor-Python: A rapid intensity-leveling and digital-staining package for fluorescence-based slide-free digital pathology by Serafin, Robert, Xie, Weisi, Glaser, Adam K, Liu, Jonathan T C

“…Slide-free digital pathology techniques, including nondestructive 3D microscopy, are gaining interest as alternatives to traditional slide-based histology. In…”
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Feature-rich covalent stains for super-resolution and cleared tissue fluorescence microscopy by Mao, Chenyi, Lee, Min Yen, Jhan, Jing-Ru, Halpern, Aaron R, Woodworth, Marcus A, Glaser, Adam K, Chozinski, Tyler J, Shin, Leonard, Pippin, Jeffrey W, Shankland, Stuart J, Liu, Jonathan T C, Vaughan, Joshua C

“…Fluorescence microscopy is a workhorse tool in biomedical imaging but often poses substantial challenges to practitioners in achieving bright or uniform…”
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Functional Imaging of Colonic Mucosa With a Fibered Confocal Microscope for Real-Time In Vivo Pathology by Wang, Thomas D, Friedland, Shai, Sahbaie, Peyman, Soetikno, Roy, Hsiung, Pei–Lin, Liu, Jonathan T.C, Crawford, James M, Contag, Christopher H

“…Background & Aims: Histologic interpretation of disease currently is performed with static images of excised tissues, and is limited by processing artifact,…”
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Microscopic Delineation of Medulloblastoma Margins in a Transgenic Mouse Model Using a Topically Applied VEGFR-1 Probe by Wang, Danni, Chen, Ye, Leigh, Steven Y, Haeberle, Henry, Contag, Christopher H, Liu, Jonathan T.C

“…Abstract The unambiguous demarcation of tumor margins is critical at the final stages in the surgical treatment of brain tumors because patient outcomes have…”
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Quantitative in vivo cell-surface receptor imaging in oncology: kinetic modeling and paired-agent principles from nuclear medicine and optical imaging by Tichauer, Kenneth M, Wang, Yu, Pogue, Brian W, Liu, Jonathan T C

“…The development of methods to accurately quantify cell-surface receptors in living tissues would have a seminal impact in oncology. For example, accurate…”
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Visualization technologies for 5-ALA-based fluorescence-guided surgeries by Wei, Linpeng, Roberts, David W., Sanai, Nader, Liu, Jonathan T. C.

“…Introduction 5-ALA-based fluorescence-guided surgery has been shown to be a safe and effective method to improve intraoperative visualization and resection of…”
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Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues by Glaser, Adam K., Reder, Nicholas P., Chen, Ye, Yin, Chengbo, Wei, Linpeng, Kang, Soyoung, Barner, Lindsey A., Xie, Weisi, McCarty, Erin F., Mao, Chenyi, Halpern, Aaron R., Stoltzfus, Caleb R., Daniels, Jonathan S., Gerner, Michael Y., Nicovich, Philip R., Vaughan, Joshua C., True, Lawrence D., Liu, Jonathan T. C.

“…Recent advances in optical clearing and light-sheet microscopy have provided unprecedented access to structural and molecular information from intact tissues…”
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Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning-Assisted Gland Analysis by Xie, Weisi, Reder, Nicholas P, Koyuncu, Can, Leo, Patrick, Hawley, Sarah, Huang, Hongyi, Mao, Chenyi, Postupna, Nadia, Kang, Soyoung, Serafin, Robert, Gao, Gan, Han, Qinghua, Bishop, Kevin W, Barner, Lindsey A, Fu, Pingfu, Wright, Jonathan L, Keene, C Dirk, Vaughan, Joshua C, Janowczyk, Andrew, Glaser, Adam K, Madabhushi, Anant, True, Lawrence D, Liu, Jonathan T C

“…Prostate cancer treatment planning is largely dependent upon examination of core-needle biopsies. The microscopic architecture of the prostate glands forms the…”
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Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy by Wang, Yu, Kang, Soyoung, Khan, Altaz, Ruttner, Gabriel, Leigh, Steven Y., Murray, Melissa, Abeytunge, Sanjee, Peterson, Gary, Rajadhyaksha, Milind, Dintzis, Suzanne, Javid, Sara, Liu, Jonathan T.C.

“…There is a need to image excised tissues during tumor-resection procedures in order to identify residual tumors at the margins and to guide their complete…”
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3D open-top light-sheet microscopy and 3D microdissection of neuoadjuvant-treated primary prostate cancer reveals latent subclonal mutations by Reder, Nicholas, Pritchard, Colin C., Konnick, Eric Q, Huang, Hongyi, Lerma, Angelica, Glaser, Adam K, True, Lawrence D, Liu, Jonathan T.C., Schweizer, Michael Thomas

“…e17109 Background: Intratumoral molecular heterogeneity is a well described phenomenon in primary prostate cancer. Increased genomic heterogeneity is…”
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Handheld line-scanned dual-axis confocal microscope with pistoned MEMS actuation for flat-field fluorescence imaging by Wei, Linpeng, Yin, Chengbo, Fujita, Yoko, Sanai, Nader, Liu, Jonathan T C

“…A handheld line-scanned dual-axis confocal (LS-DAC) microscope has been developed for high-speed (16 frames/s) fluorescence imaging of tissues with sub-nuclear…”
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Raman-Encoded Molecular Imaging with Topically Applied SERS Nanoparticles for Intraoperative Guidance of Lumpectomy by Wang, Yu Winston, Reder, Nicholas P, Kang, Soyoung, Glaser, Adam K, Yang, Qian, Wall, Matthew A, Javid, Sara H, Dintzis, Suzanne M, Liu, Jonathan T C

“…Intraoperative identification of carcinoma at lumpectomy margins would enable reduced re-excision rates, which are currently as high as 20% to 50%. Although…”
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Artificial Intelligence-Triaged 3-Dimensional Pathology to Improve Detection of Esophageal Neoplasia While Reducing Pathologist Workloads by Erion Barner, Lindsey A, Gao, Gan, Reddi, Deepti M, Lan, Lydia, Burke, Wynn, Mahmood, Faisal, Grady, William M, Liu, Jonathan T C

“…Early detection of esophageal neoplasia via evaluation of endoscopic surveillance biopsies is the key to maximizing survival for patients with Barrett's…”
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