Search Results - "Liu, Jinggong"
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Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential
Published in Cell death & disease (04-03-2021)“…Cucurbitacin B (CuB) is a widely available triterpenoid molecule that exhibits various biological activities. Previous studies on the anti-tumour mechanism of…”
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Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols
Published in Nature communications (18-06-2021)“…Contemporary asymmetric catalysis faces huge challenges when prochiral substrates bear electronically and sterically unbiased substituents and when substrates…”
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Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment
Published in Journal of nanobiotechnology (14-06-2022)“…As Traditional Chinese Medicine (TCM) drugs, Huangqi and Danshen are always applied in combination for spinal cord injury (SCI) treatment based on the…”
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A facile and general method for synthesis of antibiotic-free protein-based hydrogel: Wound dressing for the eradication of drug-resistant bacteria and biofilms
Published in Bioactive materials (01-12-2022)“…Antibacterial protein hydrogels are receiving increasing attention in the aspect of bacteria-infected-wound healing. However, bacterial drug resistance and…”
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Biomedical Application of Reactive Oxygen Species-Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases
Published in Frontiers in chemistry (18-09-2020)“…Numerous pathological conditions, including cancer, inflammatory diseases, and neurodegenerative diseases, are accompanied by overproduction of reactive oxygen…”
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Copper-catalyzed diversified annulations between α-diketones and alkynyl α-diketones
Published in Chinese chemical letters (01-06-2022)“…Copper-catalyzed divergent annulations between α-diketones and alkynyl α-diketones have been achieved, delivering a series of highly functionalized and…”
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Tumor microenvironment-responsive metal nanotherapeutics for breast cancer chemo-/immunotherapy
Published in NPG Asia materials (28-04-2023)“…Many metal complexes not only had excellent cytotoxic antitumor effects but also could function as a positive immunomodulatory to improve antitumor effects by…”
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Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease
Published in Biochimica et biophysica acta (01-09-2014)“…Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that is characterized by dementia, cognitive impairment, and memory loss. Diverse…”
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Carbene-catalyzed asymmetric Friedel–Crafts alkylation-annulation sequence and rapid synthesis of indole-fused polycyclic alkaloids
Published in Communications chemistry (24-07-2019)“…Organocatalyzed asymmetric Friedel–Craft reactions have enabled the rapid construction of chiral molecules with highly enantioselectivity enriching the toolbox…”
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Role of Hairpin-Quadruplex DNA Secondary Structural Conversion in the Promoter of hnRNP K in Gene Transcriptional Regulation
Published in Organic letters (18-09-2015)“…The promoter of hnRNP K oncogene was found to contain a G/C-rich sequence on the same DNA strand, which can form interconvertible G-quadruplex, i-motif, and…”
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Analysis of Reverse Flow in Inverted U-Tubes of Steam Generator under Natural Circulation Condition
Published in Journal of nuclear science and technology (01-12-2008)“…In this paper, we report on the analysis of reverse flow in inverted U-tubes of a steam generator under natural circulation condition. The mechanism of reverse…”
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12
Bone mesenchymal stem cell-derived extracellular vesicles promote the repair of intervertebral disc degeneration by transferring microRNA-199a
Published in Cell cycle (Georgetown, Tex.) (01-02-2021)“…Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) protect intervertebral disc degeneration (IDD) by regulating nucleus…”
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Narrow Bandgap Schottky Heterojunction Sonosensitizer with High Electron–Hole Separation Boosted Sonodynamic Therapy in Bladder Cancer
Published in Advanced materials (Weinheim) (01-06-2024)“…Sonodynamic therapy (SDT) is applied to bladder cancer (BC) given its advantages of high depth of tissue penetration and nontoxicity due to the unique…”
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Rapid Construction of Polycyclic Skeletons via Brønsted-Base-Catalyzed Annulations of Ethylidene 1,3-Indenediones and Vinyl 1,2-Diketones
Published in Organic letters (19-07-2024)“…Brønsted-base-catalyzed diversified annulations between ethylidene 1,3-indenediones and vinyl 1,2-diketones have been achieved, delivering three types of…”
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Copper-Catalyzed Asymmetric Yne-Allylic Substitution Using Electron-Rich Arenes
Published in ACS catalysis (16-02-2024)“…Remote stereocontrol in transition-metal catalysis is a challenging but interesting research topic. In this work, we achieved copper-catalyzed asymmetric…”
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N-methylbenzothiazolium based theranostics as fluorescence imaging and photo-oxidation agents for Amyloid-β
Published in Sensors and actuators. B, Chemical (01-09-2024)“…Alzheimer's disease is a progressive neurodegenerative disorder with an insidious onset of symptoms. At present, there are no treatments that can effectively…”
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Copper‐Catalysed Rearrangement of Cyclic Ethynylethylene Carbonates: Synthetic Applications and Mechanistic Studies
Published in Angewandte Chemie International Edition (27-03-2023)“…Transition‐metal‐catalysed reactions of cyclic ethynylethylene carbonates have been intensively studied because of their robustness in new bond formation and…”
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Oxa-Nazarov Cyclization-Michael Addition Sequence for the Rapid Construction of Dihydrofuranones
Published in Organic letters (09-12-2022)“…The Nazarov cyclization has been established as a powerful tool in constructing cyclopentenone skeletons. In sharp contrast, oxa-Nazarov cyclization that…”
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Asymmetric Semipinacol Rearrangement Enabled by Copper-Catalyzed Propargylic Alkylation
Published in ACS catalysis (07-10-2022)“…The merger of two powerful synthetic strategies, i.e., asymmetric semipinacol-type rearrangement and transition-metal-catalyzed propargylic alkylation, has…”
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Copper-Catalyzed Yne-Allylic Substitutions Using Stabilized Nucleophiles
Published in ACS catalysis (17-06-2022)“…Using stabilized “soft” nucleophiles in copper-catalyzed allylic substitutions is highly desirable but remains an unsolved challenge for the last 40 years. In…”
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