Search Results - "Liu, Jinggen"

Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase by Zhao, Junli, Sun, Jinyi, Zheng, Yang, Zheng, Yanrong, Shao, Yuying, Li, Yulan, Fei, Fan, Xu, Cenglin, Liu, Xiuxiu, Wang, Shuang, Ruan, Yeping, Liu, Jinggen, Duan, Shumin, Chen, Zhong, Wang, Yi

“…Epileptic seizures are widely regarded to occur as a result of the excitation-inhibition imbalance from a neuro-centric view. Although astrocyte-neuron…”
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Activation of Nrf2 antioxidant signaling alleviates gout arthritis pain and inflammation by Zeng, Danyi, Yin, Chengyu, Wei, Huina, Li, Yuanyuan, Yang, Yunqin, Nie, Huimin, Pan, Yushuang, Xu, Ruoyao, Tai, Yan, Du, Junying, Liu, Jinggen, Wang, Ping, Liu, Boyu, Liu, Boyi

“…Excessive deposition of monosodium urate (MSU) crystal in the joint results in gout arthritis, which triggers severe pain and affects life quality. Oxidative…”
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Projection-defined median raphe Pet + subpopulations are diversely implicated in seizure by Cheng, Heming, Lou, Qiuwen, Lai, Nanxi, Chen, Liying, Zhang, Shuo, Fei, Fan, Gao, Chenshu, Wu, Shuangshuang, Han, Feng, Liu, Jinggen, Guo, Yi, Chen, Zhong, Xu, Cenglin, Wang, Yi

“…The raphe nuclei, the primary resource of forebrain 5-HT, play an important but heterogeneous role in regulating subcortical excitabilities. Fundamental…”
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Deep brain stimulation in the medial septum attenuates temporal lobe epilepsy via entrainment of hippocampal theta rhythm by Wang, Ying, Shen, Yating, Cai, Xianhui, Yu, Jie, Chen, Cong, Tan, Bei, Tan, Na, Cheng, Heming, Fan, Xiang, Wu, Xiaohua, Liu, Jinggen, Wang, Shuang, Wang, Yi, Chen, Zhong

“…Aims Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the most common types of medically refractory epilepsy. Deep brain…”
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Rostral Anterior Cingulate Cortex-Ventrolateral Periaqueductal Gray Circuit Underlies Electroacupuncture to Alleviate Hyperalgesia but Not Anxiety-Like Behaviors in Mice With Spared Nerve Injury by Zhu, Xixiao, Xu, Yingling, Shen, Zui, Zhang, Haiyan, Xiao, Siqi, Zhu, Yichen, Wu, Mengwei, Chen, Yeqing, Wu, Zemin, Xu, Yunyun, He, Xiaofen, Liu, Boyu, Liu, Jinggen, Du, Junying, Sun, Jing, Fang, Jianqiao, Shao, Xiaomei

“…Neuropathic pain is a common cause of chronic pain and is often accompanied by negative emotions, making it complex and difficult to treat. However, the neural…”
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Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry by Shen, Zui, Zhang, Haiyan, Wu, Zemin, He, Qiaoying, Liu, Jinggen, Xu, Yingling, Yao, Shujing, He, Xiaofen, Chen, Yeqing, Liang, Yi, Liu, Boyi, Jiang, Yongliang, Fang, Junfan, Du, Junying, Zhu, Xixiao, Wu, Mengwei, Wu, Yuanyuan, Sun, Jing, Xu, Chi, Fang, Jianqiao, Shao, Xiaomei

“…Anxiety is a common comorbidity associated with chronic pain, which results in chronic pain complexification and difficulty in treatment. Electroacupuncture…”
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Phosphoproteomic Profiling of Rat's Dorsal Root Ganglia Reveals mTOR as a Potential Target in Bone Cancer Pain and Electro-Acupuncture's Analgesia by Wang, Wen, Zhou, You, Cai, Yangqian, Wang, Sisi, Shao, Fangbing, Du, Junying, Fang, Junfan, Liu, Jinggen, Shao, Xiaomei, Liu, Boyi, Fang, Jianqiao, Liang, Yi

“…Bone cancer pain (BCP) is a clinical refractory mixed pain involving neuropathic and inflammatory pain, with the underlying mechanisms remaining largely…”
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Synthesis and opioid receptor activity of indolopropellanes by Li, Fuying, Gaob, Linghuan, Yin, Chenlei, Chen, Jie, Liu, Jinggen, Xie, Xin, Zhang, Ao

“…A series of skeletal rearranged indolomorphinans 7a– d was synthesized, and their binding affinity and functional activity for opioid receptors were evaluated…”
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Resin Glycoside Constituents of Ipomoea pes-caprae (Beach Morning Glory) by Tao, Hongwen, Hao, Xiaojiang, Liu, Jinggen, Ding, Jian, Fang, Yuchun, Gu, Qianqun, Zhu, Weiming

“…Eight new resin glycosides, pescapreins X−XVII (1−8), were isolated from a lipophilic fraction of an ethanol extract of the entire plant of beach morning…”
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Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice by Wu, Shuo, Ning, Kuan, Wang, Yujun, Zhang, Lesha, Liu, Jinggen

“…Depressive disorder is a psychiatric disease characterized by its main symptoms of low mood and anhedonia. Due to its complex etiology, current clinical…”
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A new S-box construction method meeting strict avalanche criterion by Li, Lang, Liu, Jinggen, Guo, Ying, Liu, Botao

“…S-box is the main security component in lightweight block ciphers. Finding new algorithms and technical applications to generate S-box is still a current…”
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Electroacupuncture Alleviates Anxiety-Like Behaviors Induced by Chronic Neuropathic Pain via Regulating Different Dopamine Receptors of the Basolateral Amygdala by Wu, Mengwei, Chen, Yeqing, Shen, Zui, Zhu, Yichen, Xiao, Siqi, Zhu, Xixiao, Wu, Zemin, Liu, Jinggen, Xu, Chi, Yao, Pingan, Xu, Weiwei, Liang, Yi, Liu, Boyi, Du, Junying, He, Xiaofen, Liu, Boyu, Jin, Xiaoming, Fang, Jianqiao, Shao, Xiaomei

“…Chronic pain, such as neuropathic pain, causes anxiety and other negative emotions, which aggravates the pain sensation and increases the risk of chronic pain…”
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MALDI-MS imaging of lipids and small molecules in rat brain tissue based on graphene oxide film pre-coated matrix by Xu, Yang, Deng, Yingzhi, Ye, Rongrong, Gong, Can, Liu, Zhaoxin, Zhao, Yuezhen, Lu, Yan, Liu, Jinggen, Xu, Xu

“…In the study, single-layer graphene oxide (SLGO) was adsorbed on a conductive glass surface to prepare a uniform thin film. We used this film as the pre-coated…”
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Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic by Huang, Huoming, Wang, Wenli, Xu, Xuejun, Zhu, Chen, Wang, Yujun, Liu, Jinggen, Li, Wei, Fu, Wei

“…Management of moderate to severe pain by clinically used opioid analgesics is associated with a plethora of side effects. Despite many efforts have been…”
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Discovery of an Ortho-Substituted N -Cyclopropylmethyl-7α-phenyl-6,14- endo ethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect by Li, Zixiang, Ye, Rufeng, He, Qian, Lu, Jiashuo, Sun, Yanting, Sun, Xiujian, Tang, Siyuan, Hu, Shuyang, Chai, Jingrui, Kong, Linghui, Liu, Xiaoning, Chen, Jing, Fang, Yun, Lan, Yingjie, Xie, Qiong, Liu, Jinggen, Shao, Liming, Fu, Wei, Wang, Yujun, Li, Wei

“…Research into kappa opioid receptor (KOR) agonists with attenuated central-nervous-system side effects is a critical focus for developing productive and safe…”
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Discovery of an Ortho-Substituted N‑Cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect by Li, Zixiang, Ye, Rufeng, He, Qian, Lu, Jiashuo, Sun, Yanting, Sun, Xiujian, Tang, Siyuan, Hu, Shuyang, Chai, Jingrui, Kong, Linghui, Liu, Xiaoning, Chen, Jing, Fang, Yun, Lan, Yingjie, Xie, Qiong, Liu, Jinggen, Shao, Liming, Fu, Wei, Wang, Yujun, Li, Wei

“…Research into kappa opioid receptor (KOR) agonists with attenuated central-nervous-system side effects is a critical focus for developing productive and safe…”
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Discovery of an M -Substituted N -Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile by He, Qian, Wei, Yuanyuan, Liu, Xiao, Ye, Rongrong, Kong, Linghui, Li, Zixiang, Jiang, Shuang, Yu, Linqian, Chai, Jingrui, Xie, Qiong, Fu, Wei, Wang, Yujun, Li, Wei, Qiu, Zhuibai, Liu, Jinggen, Shao, Liming

“…The search for selective kappa opioid receptor (κOR) agonists with an improved safety profile is an area of interest in opioid research. In this work, a series…”
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SLL-627 Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity by Kong, Linghui, Shu, Xuelian, Tang, Siyuan, Ye, Rongrong, Sun, Huijiao, Jiang, Shuang, Li, Zixiang, Chai, Jingrui, Fang, Yun, Lan, Yinjie, Yu, Linqian, Xie, Qiong, Fu, Wei, Wang, Yujun, Li, Wei, Qiu, Zhuibai, Liu, Jinggen, Shao, Liming

“…Undue central nervous system (CNS) side effects including dysphoria and sedation remain to be a challenge for the development of κ opioid receptor (KOR)…”
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Discovery, Structure–Activity Relationship, and Mechanistic Studies of 1‑((3R,4S)‑3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic by Huang, Huoming, Li, Xueping, Xie, Peng, Li, Xinwei, Xu, XueJun, Qian, Yuanyuan, Yuan, Congmin, Meng, Xiangguo, Chai, JingRui, Chen, Jing, Liu, Jing, Wang, Wenli, Li, Wei, Wang, YuJun, Fu, Wei, Liu, Jinggen

“…Management of moderate to severe pain relies heavily on opioid analgesics such as morphine, oxycodone, and fentanyl in clinics. However, their prolonged use…”
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A neural circuit associated with anxiety‐like behaviors induced by chronic inflammatory pain and the anxiolytic effects of electroacupuncture by Wu, Zemin, Shen, Zui, Xu, Yingling, Chen, Shaozong, Xiao, Siqi, Ye, Jiayu, Zhang, Haiyan, Ma, Xinyi, Zhu, Yichen, Zhu, Xixiao, Jiang, Yongliang, Fang, Junfan, Liu, Boyi, He, Xiaofen, Gao, Shuzhong, Shao, Xiaomei, Liu, Jinggen, Fang, Jianqiao

“…Aims Negative emotions induced by chronic pain are a serious clinical problem. Electroacupuncture (EA) is a clinically proven safe and effective method to…”
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