Search Results - "Liu, Jeen"

Minimizing Patient Burden Through the Use of Historical Subject-Level Data in Innovative Confirmatory Clinical Trials: Review of Methods and Opportunities by Lim, Jessica, Walley, Rosalind, Yuan, Jiacheng, Liu, Jeen, Dabral, Abhishek, Best, Nicky, Grieve, Andrew, Hampson, Lisa, Wolfram, Josephine, Woodward, Phil, Yong, Florence, Zhang, Xiang, Bowen, Ed

“…The goal of clinical trial research is to deliver safe and efficacious new treatments to patients in need in a timely and cost-effective manner. There is…”
Get more information

Omalizumab is effective in the long-term control of severe allergic asthma by Lanier, Bobby Quentin, Corren, Jonathan, Lumry, William, Liu, Jeen, Fowler-Taylor, Angel, Gupta, Niroo

“…Previous reports show that addition of omalizumab to standard therapy reduces asthma exacerbations and simultaneously decreases use of inhaled corticosteroids…”
Get more information

Seamless phase IIa/IIb adaptive design with the same primary endpoint for proof of concept and dose finding by Yuan, Jiacheng, Radecki, Daniel, Bugarin, Denise, Geib, Till, Zhou, Jihao, Liu, Jeen

“…Abstract This paper considers combining a proof of concept (POC) study and a dose finding (DF) study where the POC and the DF share the same primary endpoint…”
Get full text

OnabotulinumtoxinA for the treatment of major depressive disorder: a phase 2 randomized, double-blind, placebo-controlled trial in adult females by Brin, Mitchell F., Durgam, Suresh, Lum, Arlene, James, Lynn, Liu, Jeen, Thase, Michael E., Szegedi, Armin

“…This 24-week double-blind placebo-controlled multicenter randomized phase 2 trial evaluated efficacy and safety of onabotulinumtoxinA (onabotA; BOTOX) vs…”
Get full text

Design of randomized controlled confirmatory trials using historical control data to augment sample size for concurrent controls by Yuan, Jiacheng, Liu, Jeen, Zhu, Ray, Lu, Ying, Palm, Ulo

“…This paper deals with the methods to augment concurrent controls (CC) in a randomized controlled trial with available historical data in clinical studies. In…”
Get full text

Causal inference for longitudinal data based on historical controls by Liu, Jeen, Zhang, Jane, Mitchell, Alan, Fang, Mindy, Tian, Lu

“…Use of historical data has become a hot topic recently, considered to provide a way to reduce patient burden, lower drug development cost, and make innovative…”
Get full text

Evaluation of alternative confidence intervals to address non‐inferiority through the stratified difference between proportions by Sui, Jiatong, Jiao, Jenny, Sun, Yijun, Liu, Jeen, Bastero, Rowena, Koch, Gary

“…SUMMARY The confidence interval (CI) for the difference between two proportions has been an important and active research topic, especially in the context of…”
Get full text

Evaluation of alternative confidence intervals to address n on‐inferiority through the stratified difference between proportions by Sui, Jiatong, Jiao, Jenny, Sun, Yijun, Liu, Jeen, Bastero, Rowena, Koch, Gary

“…SUMMARY The confidence interval (CI) for the difference between two proportions has been an important and active research topic, especially in the context of…”
Get full text

Treating major depressive disorder with onabotulinumtoxinA: Safety and efficacy 24 weeks following a single injection session by Brin, Mitchell, Szegedi, Armin, Lum, Arlene, Liu, Jeen, Thase, Michael E.

Get full text

Clinical Study Design to Assess Both Short- and Long-term Efficacy in Addition to Group Sequential Test on Safety by Yuan, Jiacheng, Mesenbrink, Peter, Zhou, Jihao, Liu, Jeen, Zhu, Ray, Koch, Gary

“…In clinical studies for disorders such as rheumatoid arthritis, type 2 diabetes mellitus, multiple sclerosis, osteoporosis, etc, sometimes the developers need…”
Get more information

Omalizumab improves asthma-related quality of life in patients with severe allergic asthma by Finn, Albert, Gross, Gary, van Bavel, Julius, Lee, Theodore, Windom, Hugh, Everhard, François, Fowler-Taylor, Angel, Liu, Jeen, Gupta, Niroo

“…Background: We have previously shown that omalizumab, a recombinant humanized monoclonal anti-IgE antibody, reduces asthma exacerbations and decreases inhaled…”
Get full text

Efficacy of omalizumab, an anti-immunoglobulin E antibody, in patients with allergic asthma at high risk of serious asthma-related morbidity and mortality by HOLGATE, Stephen, BOUSQUET, Jean, WENZEL, Sally, FOX, Howard, LIU, Jeen, CASTELLSAGUE, Jordi

“…Add-on therapy with omalizumab, an anti-immunoglobulin E antibody, is effective in improving disease control in patients with allergic asthma of varying…”
Get full text

Efficacy of omalizumab in allergic asthma patients at high-risk for asthma-related death by Bousquet, Jean, Holgate, Stephen, Fox, Howard, Liu, Jeen, Castellsague, Jordi

Get full text

Efficacy of Omalizumab, an Anti-immunoglobulin E Antibody, in Patients with Allergic Asthma at High Risk of Serious Asthma-related Morbidity and Mortality by Holgate, Stephen, Bousquet, Jean, Wenzel, Sally, Fox, Howard, Liu, Jeen, Castellsague, Jordi

“…SummaryAim: Add-on therapy with omalizumab, an anti-immunoglobulin E antibody, is effective in improving disease control in patients with allergic asthma of…”
Get full text