Search Results - "Liu, Hudan"

Targeting oncogenic Myc as a strategy for cancer treatment by Chen, Hui, Liu, Hudan, Qing, Guoliang

“…The MYC family oncogene is deregulated in >50% of human cancers, and this deregulation is frequently associated with poor prognosis and unfavorable patient…”
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Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat by Dong, Yang, Tu, Rongfu, Liu, Hudan, Qing, Guoliang

“…Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and proliferation. As such, most human cancers differ from normal…”
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Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis by Yue, Ming, Jiang, Jue, Gao, Peng, Liu, Hudan, Qing, Guoliang

“…Most tumor cells exhibit obligatory demands for essential amino acids (EAAs), but the regulatory mechanisms whereby tumor cells take up EAAs and EAAs promote…”
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EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation by Wang, Liyuan, Chen, Chan, Song, Zemin, Wang, Honghong, Ye, Minghui, Wang, Donghai, Kang, Wenqian, Liu, Hudan, Qing, Guoliang

“…Efforts to therapeutically target EZH2 have generally focused on inhibition of its methyltransferase activity, although it remains less clear whether this is…”
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Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival by Xiao, Daibiao, Yue, Ming, Su, Hexiu, Ren, Ping, Jiang, Jue, Li, Feng, Hu, Yufeng, Du, Haining, Liu, Hudan, Qing, Guoliang

“…MYCN amplification in human cancers predicts poor prognosis and resistance to therapy. However, pharmacological strategies that directly target N-Myc, the…”
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ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation by Ren, Ping, Yue, Ming, Xiao, Daibiao, Xiu, Ruijuan, Gan, Lei, Liu, Hudan, Qing, Guoliang

“…Amplification of the MYCN gene in human neuroblastoma predicts poor prognosis and resistance to therapy. We previously showed that MYCN‐amplified neuroblastoma…”
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USP29 coordinates MYC and HIF1α stabilization to promote tumor metabolism and progression by Tu, Rongfu, Kang, Wenqian, Yang, Mengjie, Wang, Liyuan, Bao, Qing, Chen, Zhi, Dong, Yang, Wang, Jingchao, Jiang, Jue, Liu, Hudan, Qing, Guoliang

“…Tumor cells must rewire cellular metabolism to satisfy the demands of unbridled growth and proliferation. How these metabolic processes are integrated to fuel…”
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Differential regulation of microRNA stability by Bail, Sophie, Swerdel, Mavis, Liu, Hudan, Jiao, Xinfu, Goff, Loyal A, Hart, Ronald P, Kiledjian, Megerditch

“…MicroRNAs (miRNAs) are endogenous single-stranded RNA molecules of about 21 nucleotides in length that are fundamental post-transcriptional regulators of gene…”
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pH-Sensitive Docetaxel-Loaded d‑α-Tocopheryl Polyethylene Glycol Succinate–Poly(β-amino ester) Copolymer Nanoparticles for Overcoming Multidrug Resistance by Zhao, Shuang, Tan, Songwei, Guo, Yuanyuan, Huang, Jing, Chu, Min, Liu, Hudan, Zhang, Zhiping

“…Multidrug resistance (MDR) is one of the major obstacles to successful chemotherapy. Overexpression of drug efflux transporters such as P-glycoprotein (P-gp)…”
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Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability by Ye, Minhui, Fang, Yingzhe, Chen, Lu, Song, Zemin, Bao, Qing, Wang, Fei, Huang, Hao, Xu, Jin, Wang, Ziwen, Xiao, Ruijing, Han, Meng, Gao, Song, Liu, Hudan, Jiang, Baishan, Qing, Guoliang

“…Tumor cells must rewire nucleotide synthesis to satisfy the demands of unbridled proliferation. Meanwhile, they exhibit augmented reactive oxygen species (ROS)…”
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WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia by Hu, Juncheng, Wang, Tianci, Xu, Jin, Wu, Sanyun, Wang, Liyuan, Su, Hexiu, Jiang, Jue, Yue, Ming, Wang, Jingchao, Wang, Donghai, Li, Peng, Zhou, Fuling, Liu, Yu, Qing, Guoliang, Liu, Hudan

“…T-cell acute lymphoblastic leukemias (T-ALLs) are aggressive and heterogeneous hematologic tumors resulting from the malignant transformation of T-cell…”
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Stabilization of Notch1 by the Hsp90 Chaperone Is Crucial for T-Cell Leukemogenesis by Wang, Zhaojing, Hu, Yufeng, Xiao, Daibiao, Wang, Jingchao, Liu, Chuntao, Xu, Yisheng, Shi, Xiaomeng, Jiang, Peng, Huang, Liang, Li, Peng, Liu, Hudan, Qing, Guoliang

“…Notch1 deregulation is assuming a focal role in T-cell acute lymphoblastic leukemia (T-ALL). Despite tremendous advances in our understanding of Notch1…”
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Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2 by Xiao, Daibiao, Ren, Ping, Su, Hexiu, Yue, Ming, Xiu, Ruijuan, Hu, Yufeng, Liu, Hudan, Qing, Guoliang

“…Deamidation of glutamine to glutamate by glutaminase 1 (GLS1, also called GLS) and GLS2 is an essential step in both glutaminolysis and glutathione (GSH)…”
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RNA helicase DHX15 exemplifies a unique dependency in acute leukemia by Guo, Hao, Xu, Jin, Xing, Peiqi, Li, Qilong, Wang, Donghai, Tang, Chao, Palhais, Bruno, Roels, Juliette, Liu, Jiaxu, Pan, Sa, Huang, Jinyan, Liu, Zhaoqi, Zhu, Ping, Taghon, Tom, Qing, Guoliang, Van Vlierberghe, Pieter, Liu, Hudan

“…RNA-binding proteins (RBP) have emerged as essential regulators that control gene expression and modulate multiple cancer traits. T-cell acute lymphoblastic…”
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Interferon-stimulated gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma by Li, Chong, Wang, Ji, Zhang, Hong, Zhu, Mingao, Chen, Feifei, Hu, Yufeng, Liu, Hudan, Zhu, Hong

“…Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with poor prognosis. IFN-stimulated genes 15 (ISG15) is an ubiquitin-like molecule…”
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SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival by Su, Hexiu, Hu, Juncheng, Huang, Liang, Yang, Yang, Thenoz, Morgan, Kuchmiy, Anna, Hu, Yufeng, Li, Peng, Feng, Hui, Zhou, Yu, Taghon, Tom, Van Vlierberghe, Pieter, Qing, Guoliang, Chen, Zhichao, Liu, Hudan

“…T-acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with complicated heterogeneity. Although expression profiling reveals common…”
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MYC in T-cell acute lymphoblastic leukemia: functional implications and targeted strategies by Li, Qilong, Pan, Sa, Xie, Ting, Liu, Hudan

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer that frequently occurs in children and adolescents, which results from the…”
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Intertwined regulation between RNA m6A modification and cancer metabolism by Liu, Jiaxu, Huang, Hao, Zhang, Minghao, Qing, Guoliang, Liu, Hudan

“…RNA N6-methyladenosine (m6A) has been identified as the most common, abundant and conserved internal modification in RNA transcripts, especially within…”
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Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia by Ye, Qi, Jiang, Jue, Zhan, Guanqun, Yan, Wanyao, Huang, Liang, Hu, Yufeng, Su, Hexiu, Tong, Qingyi, Yue, Ming, Li, Hua, Yao, Guangmin, Zhang, Yonghui, Liu, Hudan

“…Aberrant activation of the NOTCH signaling pathway is crucial for the onset and progression of T cell leukemia. Yet recent studies also suggest a tumor…”
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The NOTCH ligand JAGGED2 promotes pancreatic cancer metastasis independent of NOTCH signaling activation by Hu, Yufeng, Su, Hexiu, Li, Xu, Guo, Guoli, Cheng, Ling, Qin, Renyi, Qing, Guoliang, Liu, Hudan

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal disease with a high rate of metastasis. Numerous signaling events have been implicated in…”
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