Search Results - "Liu, Hans"

Safety Profile of the Fluoroquinolones: Focus on Levofloxacin by Liu, Hans H.

“…The fluoroquinolone class of antibacterial agents are among the most frequently prescribed drugs, with utility in a broad range of bacterial infections…”
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Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion by Wang, Fengrong, Chen, Song, Liu, Hans B, Parent, Carole A, Coulombe, Pierre A

“…The a and b isoforms of keratin 6 (K6), a type II intermediate filament (IF) protein, are robustly induced upon injury to interfollicular epidermis. We…”
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Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption by Swift, Russell P, Rajaram, Krithika, Liu, Hans B, Prigge, Sean T

“…Malaria parasites contain an essential organelle called the apicoplast that houses metabolic pathways for fatty acid, heme, isoprenoid, and iron–sulfur cluster…”
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A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites by Swift, Russell P, Rajaram, Krithika, Liu, Hans B, Dziedzic, Amanda, Jedlicka, Anne E, Roberts, Aleah D, Matthews, Krista A, Jhun, Hugo, Bumpus, Namandje N, Tewari, Shivendra G, Wallqvist, Anders, Prigge, Sean T

“…Malaria parasites rely on a plastid organelle for survival during the blood stages of infection. However, the entire organelle is dispensable as long as the…”
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GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms by Salles, Daniela C, Asrani, Kaushal, Woo, Juhyung, Vidotto, Thiago, Liu, Hans B, Vidal, Igor, Matoso, Andres, Netto, George J, Argani, Pedram, Lotan, Tamara L

“…GPNMB (glycoprotein nonmetastatic B) and other TFE3/TFEB transcriptional targets have been proposed as markers for microphthalmia (MiT) translocation renal…”
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Role of Bβ1 overexpression in the pathogenesis of SCA12 by Zhou, Chengqian, Tang, Fan, Dong, Tao, Liu, Hans B., Deng, Leon, Margolis, Russell L., Li, Pan P.

“…Background Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative disease caused by a CAG/CTG repeat expansion at the PPP2R2B locus. Objective We…”
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Bidirectional Transcription at the PPP2R2B Gene Locus in Spinocerebellar Ataxia Type 12 by Zhou, Chengqian, Liu, Hans B., Jahanbakhsh, Fatemeh, Deng, Leon, Wu, Bin, Ying, Mingyao, Margolis, Russell L., Li, Pan P.

“…Background Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative disease caused by expansion of a CAG repeat in the PPP2R2B gene. Objective In this…”
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An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss by Asrani, Kaushal, Woo, Juhyung, Mendes, Adrianna A., Schaffer, Ethan, Vidotto, Thiago, Villanueva, Clarence Rachel, Feng, Kewen, Oliveira, Lia, Murali, Sanjana, Liu, Hans B., Salles, Daniela C., Lam, Brandon, Argani, Pedram, Lotan, Tamara L.

“…The mechanistic target of rapamycin complex 1 (mTORC1) integrates inputs from growth factors and nutrients, but how mTORC1 autoregulates its activity remains…”
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Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparum Parasites by Swift, Russell P, Rajaram, Krithika, Elahi, Rubayet, Liu, Hans B, Prigge, Sean T

“…Ferredoxin (Fd) and ferredoxin-NADP+ reductase (FNR) form a redox system that is hypothesized to play a central role in the maintenance and function of the…”
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Bacterial and fungal growth in sputum cultures from 165 COVID-19 pneumonia patients requiring intubation: evidence for antimicrobial resistance development and analysis of risk factors by Liu, Hans H, Yaron, David, Piraino, Amanda Stahl, Kapelusznik, Luciano

“…Abstract Background Coronavirus SARS-CoV-2 causes COVID-19 illness which can progress to severe pneumonia. Empiric antibacterials are often employed though…”
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The Plasmodium falciparum apicoplast cysteine desulfurase provides sulfur for both iron-sulfur cluster assembly and tRNA modification by Swift, Russell P, Elahi, Rubayet, Rajaram, Krithika, Liu, Hans B, Prigge, Sean T

“…Iron-sulfur clusters (FeS) are ancient and ubiquitous protein cofactors that play fundamental roles in many aspects of cell biology. These cofactors cannot be…”
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Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites by Zou, Roger S., Marin-Gonzalez, Alberto, Liu, Yang, Liu, Hans B., Shen, Leo, Dveirin, Rachel K., Luo, Jay X. J., Kalhor, Reza, Ha, Taekjip

“…Here we present an approach that combines a clustered regularly interspaced short palindromic repeats (CRISPR) system that simultaneously targets hundreds of…”
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Genetically engineered human induced pluripotent stem cells for the production of brain-targeting extracellular vesicles by Tang, Fan, Dong, Tao, Zhou, Chengqian, Deng, Leon, Liu, Hans B, Wang, Wenshen, Liu, Guanshu, Ying, Mingyao, Li, Pan P

“…Extracellular vesicles (EVs) are cell-secreted membrane vesicles that have become a promising, natural nanoparticle system for delivering either naturally…”
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The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum by Swift, Russell P, Rajaram, Krithika, Keutcha, Cyrianne, Liu, Hans B, Kwan, Bobby, Dziedzic, Amanda, Jedlicka, Anne E, Prigge, Sean T

“…The apicoplast of parasites is believed to rely on the import of three-carbon phosphate compounds for use in organelle anabolic pathways, in addition to the…”
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Generation of a human induced pluripotent stem cell line JHUi004-A with heterozygous mutation for spinocerebellar ataxia type 12 using genome editing by Liu, Hans B., Dong, Tao, Deng, Leon, Zhou, Chengqian, Tang, Fan, Margolis, Russell L., Li, Pan P.

“…Spinocerebellar ataxia type 12 (SCA12) is caused by a CAG expansion mutation in PPP2R2B, a gene encoding brain-specific regulatory units of protein phosphatase…”
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Redesigned TetR-Aptamer System To Control Gene Expression in Plasmodium falciparum by Rajaram, Krithika, Liu, Hans B., Prigge, Sean T.

“…One of the most powerful approaches to understanding gene function involves turning genes on and off at will and measuring the impact at the cellular or…”
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Multiple forms of discrimination, social status, and telomere length: Interactions within race by Pantesco, Elizabeth J., Leibel, Daniel K., Ashe, Jason J., Waldstein, Shari R., Katzel, Leslie I., Liu, Hans B., Weng, Nan-ping, Evans, Michele K., Zonderman, Alan B., Beatty Moody, Danielle L.

“…Previous research has demonstrated inverse associations between experiences of interpersonal discrimination and telomere length, a marker of cellular aging…”
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Telomere Shortening, Inflammatory Cytokines, and Anti-Cytomegalovirus Antibody Follow Distinct Age-Associated Trajectories in Humans by Lustig, Ana, Liu, Hans B, Metter, E Jeffrey, An, Yang, Swaby, Melissa A, Elango, Palchamy, Ferrucci, Luigi, Hodes, Richard J, Weng, Nan-Ping

“…A number of biological parameters have been cited as hallmarks of immune aging. However, it is not clear whether these multiple biological changes are the…”
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Testing the feasibility of operationalizing a prospective, randomized trial with remote cardiac safety EKG monitoring during a pandemic by Liu, Hans H., Ezekowitz, Michael D., Columbo, Michele, Khan, Oneib, Martin, Jack, Spahr, Judith, Yaron, David, Cushinotto, Lisa, Kapelusznik, Luciano

“…Background The coronavirus SARS-CoV-2 is highly contagious. Hydroxychloroquine (HCQ) has in vitro activity against SARS-CoV-2. The FDA authorized emergency use…”
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The future is now: our experience starting a remote clinical trial during the beginning of the COVID-19 pandemic by Liu, Hans H, Ezekowitz, Michael D, Columbo, Michele, Khan, Oneib, Martin, Jack, Spahr, Judith, Yaron, David, Cushinotto, Lisa, Kapelusznik, Luciano

“…The World Health Organization declared the outbreak of SARS-CoV-2 a pandemic on February 11, 2020. This organism causes COVID-19 disease and the rapid rise in…”
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