Search Results - "Liu, Fanny C"

Metastability of Protein Solution Structures in the Absence of a Solvent: Rugged Energy Landscape and Glass-like Behavior by Cropley, Tyler. C., Liu, Fanny. C., Chai, Mengqi, Bush, Matthew F., Bleiholder, Christian

“…Native ion mobility/mass spectrometry is well-poised to structurally screen proteomes but characterizes protein structures in the absence of a solvent. This…”
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Comment on Effective Temperature and Structural Rearrangement in Trapped Ion Mobility Spectrometry by Bleiholder, Christian, Liu, Fanny C, Chai, Mengqi

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Structure Relaxation Approximation (SRA) for Elucidation of Protein Structures from Ion Mobility Measurements by Bleiholder, Christian, Liu, Fanny C

“…Ion mobility spectrometry–mass spectrometry methods offer the potential to correlate protein tertiary and quaternary structures to variations in their amino…”
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A Transferable, Sample-Independent Calibration Procedure for Trapped Ion Mobility Spectrometry (TIMS) by Chai, Mengqi, Young, Meggie N, Liu, Fanny C, Bleiholder, Christian

“…Ion mobility spectrometry-mass spectrometry (IMS-MS) determines momentum transfer cross sections of ions to elucidate their structures. Recent IMS methods…”
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On the structural denaturation of biological analytes in trapped ion mobility spectrometry - mass spectrometry by Liu, Fanny C, Kirk, Samuel R, Bleiholder, Christian

“…Key to native ion mobility/mass spectrometry is to prevent the structural denaturation of biological molecules in the gas phase. Here, we systematically assess…”
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Elucidating Structures of Protein Complexes by Collision-Induced Dissociation at Elevated Gas Pressures by Liu, Fanny C., Cropley, Tyler C., Bleiholder, Christian

“…Ion activation methods carried out at gas pressures compatible with ion mobility separations are not yet widely established. This limits the analytical utility…”
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Tandem-trapped ion mobility spectrometry/mass spectrometry ( t TIMS/MS): a promising analytical method for investigating heterogenous samples by Liu, Fanny C, Ridgeway, Mark E, Park, Melvin A, Bleiholder, Christian

“…Ion mobility spectrometry/mass spectrometry (IMS/MS) is widely used to study various levels of protein structure. Here, we review the current state of affairs…”
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Structural Analysis of the Glycoprotein Complex Avidin by Tandem-Trapped Ion Mobility Spectrometry–Mass Spectrometry (Tandem-TIMS/MS) by Liu, Fanny C, Cropley, Tyler C, Ridgeway, Mark E, Park, Melvin A, Bleiholder, Christian

“…Glycoproteins play a central role in many biological processes including disease mechanisms. Nevertheless, because glycoproteins are heterogeneous entities, it…”
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Structure Relaxation Approximation (SRA) for Elucidation of Protein Structures from Ion Mobility Measurements (II). Protein Complexes by Cropley, Tyler C., Liu, Fanny C., Pedrete, Thais, Hossain, Md Amin, Agar, Jeffrey N., Bleiholder, Christian

“…Characterizing structures of protein complexes and their disease-related aberrations is essential to understanding molecular mechanisms of many biological…”
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Tandem Trapped Ion Mobility Spectrometry/Mass Spectrometry (tTIMS/MS) Reveals Sequence-Specific Determinants of Top-Down Protein Fragment Ion Cross Sections by Liu, Fanny C., Kirk, Samuel R., Caldwell, Kirsten A., Pedrete, Thais, Meier, Florian, Bleiholder, Christian

“…Top-down proteomics provides a straightforward approach to the level of proteoforms but remains technologically challenging. Using ion mobility…”
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Top-Down Protein Analysis by Tandem-Trapped Ion Mobility Spectrometry/Mass Spectrometry (Tandem-TIMS/MS) Coupled with Ultraviolet Photodissociation (UVPD) and Parallel Accumulation/Serial Fragmentation (PASEF) MS/MS Analysis by Liu, Fanny C., Ridgeway, Mark E., Wootton, Christopher A., Theisen, Alina, Panczyk, Erin M., Meier, Florian, Park, Melvin A., Bleiholder, Christian

“…“Top-down” proteomics analyzes intact proteins and identifies proteoforms by their intact mass as well as the observed fragmentation pattern in tandem mass…”
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On the Preservation of Non-covalent Peptide Assemblies in a Tandem-Trapped Ion Mobility Spectrometer-Mass Spectrometer (TIMS-TIMS-MS) by Kirk, Samuel R., Liu, Fanny C., Cropley, Tyler C., Carlock, Hunter R., Bleiholder, Christian

“…Ion mobility spectrometry-mass spectrometry (IMS-MS) has demonstrated the ability to characterize structures of weakly-bound peptide assemblies. However, these…”
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Tandem‐trapped ion mobility spectrometry/mass spectrometry coupled with ultraviolet photodissociation by Liu, Fanny C., Ridgeway, Mark E., Winfred, J. S. Raaj Vellore, Polfer, Nicolas C., Lee, Jusung, Theisen, Alina, Wootton, Christopher A., Park, Melvin A., Bleiholder, Christian

“…Rationale Tandem‐ion mobility spectrometry/mass spectrometry methods have recently gained traction for the structural characterization of proteins and protein…”
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Evaluation of a Commercial TIMS-Q-TOF Platform for Native Mass Spectrometry by Panczyk, Erin M., Lin, Yu-Fu, Harvey, Sophie R., Snyder, Dalton T., Liu, Fanny C., Ridgeway, Mark E., Park, Melvin A., Bleiholder, Christian, Wysocki, Vicki H.

“…Mass-spectrometry based assays in structural biology studies measure either intact or digested proteins. Typically, different mass spectrometers are dedicated…”
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Perspective on the potential of tandem-ion mobility /mass spectrometry methods for structural proteomics applications by Cropley, Tyler C, Chai, Mengqi, Liu, Fanny C, Bleiholder, Christian

“…Cellular processes are usually carried out collectively by the entirety of all proteins present in a biological cell, i.e. the proteome. Mass…”
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Comment on Effective Temperature and Structural Rearrangement in Trapped Ion Mobility Spectrometry: TIMS Enables Native Mass Spectrometry Applications by Bleiholder, Christian, Liu, Fanny C., Chai, Mengqi

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Printing Peptide arrays with a complementary metal oxide semiconductor chip by Loeffler, Felix F, Cheng, Yun-Chien, Muenster, Bastian, Striffler, Jakob, Liu, Fanny C, Ralf Bischoff, F, Doersam, Edgar, Breitling, Frank, Nesterov-Mueller, Alexander

“…: In this chapter, we discuss the state-of-the-art peptide array technologies, comparing the spot technique, lithographical methods, and microelectronic…”
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