Search Results - "Liu, Fabao"
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PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Published in Nature cell biology (01-11-2017)“…Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related…”
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Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)
Published in Oncotarget (05-01-2016)“…Highly up-regulated in liver cancer (HULC) is a long non-coding RNA (lncRNA). We found that HULC up-regulated sphingosine kinase 1 (SPHK1), which is involved…”
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Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS/p38 MAPK/DGAT1 pathway and inhibiting M2 macrophage polarization
Published in Redox biology (01-10-2022)“…Bile acids are steroid synthesized in liver, which are essential for fat emulsification, cholesterol excretion and gut microbial homeostasis. However, the role…”
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Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition
Published in Nature communications (24-05-2017)“…Protein arginine methyltransferases (PRMTs) introduce arginine methylation, a post-translational modification with the increasingly eminent role in normal…”
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PKM2‐TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability
Published in The EMBO journal (15-11-2021)“…The pyruvate kinase M2 isoform (PKM2) is preferentially expressed in cancer cells to regulate anabolic metabolism. Although PKM2 was recently reported to…”
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Hepatitis B Virus X Protein Inhibits Tumor Suppressor miR-205 through Inducing Hypermethylation of miR-205 Promoter to Enhance Carcinogenesis
Published in Neoplasia (New York, N.Y.) (01-11-2013)“…Abstract The infection of hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma (HCC), in which HBV X protein (HBx)…”
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Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT
Published in Biochemical and biophysical research communications (07-02-2014)“…•Relative to wild type HBx, HBX mutant HBxΔ127 strongly enhances cell proliferation.•Relative to wild type HBx, HBxΔ127 remarkably up-regulates miR-215 in…”
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Analysis of Land Surface Temperature Evolution Based on Regional Road Scope
Published in Advances in civil engineering (2020)“…To balance sustainable road construction and environmental impact, intrinsic relationships between regional road networks and land surface temperature (LST)…”
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Mediator complex subunit 12 is a gatekeeper of SARS-CoV-2 infection in breast cancer cells
Published in Genes & diseases (01-01-2022)Get full text
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The role of lactic acid adsorption by ion exchange chromatography
Published in PloS one (11-11-2010)“…The polyacrylic resin Amberlite IRA-67 is a promising adsorbent for lactic acid extraction from aqueous solution, but little systematic research has been…”
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Surfactant and Chaotropic Agent Assisted Sequential Extraction/On-Pellet Digestion (SCAD) for Enhanced Proteomics
Published in Journal of proteome research (03-08-2018)“…As a popular sample preparation approach, filter-aided sample preparation (FASP) has been widely used in proteomic analysis. However, several limitations have…”
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Proteome-wide Profiling of Asymmetric Di-Methylated Arginine in Human Breast Tumors
Published in Journal of the American Society for Mass Spectrometry (18-07-2023)“…Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) is a prevalent posttranslational modification (PTM) which regulates diverse…”
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HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer
Published in Biochemical and biophysical research communications (11-03-2017)“…The oncoprotein hepatitis B X-interacting protein (HBXIP) results in the dysregulation of lipid metabolism to enhance the development of breast cancer…”
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Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells
Published in Carcinogenesis (New York) (01-07-2013)“…Hepatitis B virus X protein (HBx) contributes to the development of hepatocellular carcinoma (HCC) through inducing dysregulation of lipogenesis. However, the…”
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PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells
Published in Molecular cell (18-03-2021)“…Aberrant cell proliferation is a hallmark of cancer, including glioblastoma (GBM). Here we report that protein arginine methyltransferase (PRMT) 6 activity is…”
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Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade
Published in Cancer research (Chicago, Ill.) (15-08-2016)“…Abnormal lipid metabolism is a hallmark of tumorigenesis. Accumulating evidence demonstrates that fatty acid synthase (FAS, FASN) is a metabolic oncogene that…”
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Site-specific characterization and quantitation of N-glycopeptides in PKM2 knockout breast cancer cells using DiLeu isobaric tags enabled by electron-transfer/higher-energy collision dissociation (EThcD)
Published in Analyst (London) (29-05-2018)“…The system-wide site-specific analysis of intact glycopeptides is crucial for understanding the exact functional relevance of protein glycosylation. A…”
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Proteome-wide Profiling of Asymmetric Dimethylated Arginine in Human Breast Tumors
Published in Journal of the American Society for Mass Spectrometry (02-08-2023)“…Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) is a prevalent post-translational modification (PTM) that regulates diverse…”
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The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells
Published in Cancer letters (01-06-2013)“…Abstract Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein. In this study, we found that the expression levels of HBXIP were positively…”
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