Search Results - "Liu, David Y"

PTG-100, an Oral α4β7 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis by Sandborn, William J., Mattheakis, Larry C., Modi, Nishit B., Pugatch, David, Bressler, Brian, Lee, Scott, Bhandari, Raj, Kanwar, Bittoo, Shames, Richard, D’Haens, Geert, Schreiber, Stefan, Danese, Silvio, Feagan, Brian, Pai, Rish K., Liu, David Y., Gupta, Suneel

“…Oral therapies targeting the integrin α4β7 may offer unique advantages for the treatment of inflammatory bowel disease. We characterized the oral α4β7…”
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Broadly Absorbing Black to Transmissive Switching Electrochromic Polymers by Shi, Pengjie, Amb, Chad M., Knott, Eric P., Thompson, Emily J., Liu, David Y., Mei, Jianguo, Dyer, Aubrey L., Reynolds, John R.

“…Random donor‐acceptor conjugated copolymers with broad and even absorption across the visible region exhibit black neutral states and highly transmissive…”
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Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease by Del Balzo, Ughetta, Signore, Pierre E, Walkinshaw, Gail, Seeley, Todd W, Brenner, Mitchell C, Wang, Qingjian, Guo, Guangjie, Arend, Michael P, Flippin, Lee A, Chow, F Aisha, Gervasi, David C, Kjaergaard, Christian H, Langsetmo, Ingrid, Guenzler, Volkmar, Liu, David Y, Klaus, Steve J, Lin, Al, Neff, Thomas B

“…Anemia of chronic kidney disease (CKD) is a multifactorial disorder caused by impaired erythropoietin (EPO) production and altered iron homeostasis associated…”
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Poly[Bis-EDOT-Isoindigo]: An Electroactive Polymer Applied to Electrochemical Supercapacitors by Estrada, Leandro A, Liu, David Y, Salazar, Danielle H, Dyer, Aubrey L, Reynolds, John R

“…Poly[6,6′-bis(ethylene-3,4-dioxythien-2-yl)]-N,N′-dialkylisoindigo (PBEDOT-iI) was synthesized and incorporated as an electroactive material into…”
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Structure-Performance Correlations in Spray-Processable Green Dioxythiophene-Benzothiadiazole Donor–Acceptor Polymer Electrochromes by Beaujuge, Pierre M, Vasilyeva, Svetlana V, Liu, David Y, Ellinger, Stefan, McCarley, Tracy D, Reynolds, John R

“…The continuing search for relevant structure–property relationships in the area of organic electronics is expected to impact both intrinsic material…”
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Synthesis of Poly(3-dodecyl-2,5-thienylene vinylene) by Solid-State Metathesis Polycondensation by Delgado, Paula A., Liu, David Y., Kean, Zachary, Wagener, Kenneth B.

“…The synthesis of poly(thienylene vinylenes) (PTV) has been attracting attention due to the low band gaps and high electrical conductivities of these materials,…”
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Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer by Seeley, Todd W, Sternlicht, Mark D, Klaus, Stephen J, Neff, Thomas B, Liu, David Y

“…The effects of pharmacological hypoxia-inducible factor (HIF) stabilization were investigated in the MMTV-Neu -YD5 (NeuYD) mouse model of breast cancer. This…”
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The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration by Zhang, Regan-Heng, Judson, Robert N, Liu, David Y, Kast, Jürgen, Rossi, Fabio M V

“…Euchromatic histone-lysine N-methyltransferase 2 (G9a/Ehmt2) is the main enzyme responsible for the apposition of H3K9 di-methylation on histones. Due to its…”
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A Case of Acute Motor Sensory Axonal Neuropathy: A Variant of Guillain-Barré Syndrome, with Possible Syndrome of Irreversible Lithium-Effectuated Neurotoxicity by Wynbrandt, Jonathan H., Gregorin, Jason A., Hollenbach, Jessica R., Liu, David Y.

“…Acute Motor Sensory Axonal Neuropathy (AMSAN) is a rare and severe variant of Guillain-Barré syndrome (GBS) that has a prolonged recovery course. GBS is often…”
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Dioxythiophene-Based Polymer Electrodes for Supercapacitor Modules by Liu, David Y, Reynolds, John R

“…We report on the electrochemical and capacitive behaviors of poly(2,2-dimethyl-3,4-propylene-dioxythipohene) (PProDOT-Me2) films as polymeric electrodes in…”
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Application of NASA-Unified WRF model to carbon dioxide simulation- model development and evaluation by Tao, Zhining, Kawa, Stephan R., Jacob, Jossy P., Liu, David Y., Collatz, George J., Wang, James S., Ott, Lesley E., Chin, Mian

“…The NASA-Unified Weather Research and Forecasting model has been coupled with the Carnegie-Ames-Stanford Approach biogeochemical model/Global Fire Emissions…”
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Loss of IFNγ Receptor Is an Independent Prognostic Factor in Ovarian Cancer by DUNCAN, Timothy J, ROLLAND, Phil, DEEN, Suha, SCOTT, Ian V, LIU, David T. Y, SPENDLOVE, Ian, DURRANT, Lindy G

“…Purpose: There is evidence that IFNγ plays an important role in ovarian cancer development. IFNγ produces numerous antitumor effects and it may be evasion of…”
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Reduction of acute and reactivated colitis in rats by an inhibitor of neutrophil activation by Wallace, J L, McKnight, W, Asfaha, S, Liu, D Y

“…Neutrophils have been implicated as major contributors to tissue injury in inflammatory bowel disease. In this study, we have assessed the effects of an…”
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In Situ Spectroscopic Analysis of Sub-Second Switching Polymer Electrochromes by Liu, David Y., Chilton, Andrew D., Shi, Pengjie, Craig, Michael R., Miles, Steven D., Dyer, Aubrey L., Ballarotto, Vincent W., Reynolds, John R.

“…As electrochromic polymers can switch with a high transmittance contrast in the sub‐second time frame, an analytical tool to rapidly probe the…”
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Vascular Endothelial Growth Factor Expression in Ovarian Cancer: A Model for Targeted Use of Novel Therapies? by Duncan, Timothy J, Al-Attar, Ahmad, Rolland, Phil, Scott, Ian V, Deen, Suha, Liu, David T Y, Spendlove, Ian, Durrant, Lindy G

“…Purpose: Angiogenesis has a vital role in tumor growth and metastasis, and vascular endothelial growth factor (VEGF) represents a potent cytokine in this…”
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Rusfertide Analog-PN23114 As a Hepcidin Mimetic Provides Efficacy Benefits in Conjunction with Phlebotomy in Mouse Model for Hereditary Hemochromatosis by Taranath, Roopa, Dion, Celino, Bhandari, Ashok, Liu, David Y

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Integrins as a Primary Signal Transduction Molecule Regulating Monocyte Immediate-Early Gene Induction by Yurochko, Andrew D., Liu, David Y., Eierman, David, Haskill, Stephen

“…Integrins are cell surface receptors found on monocytes that facilitate adhesion to both cellular and extracellular substrates. These integrins are thought to…”
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Iron Restricted Erythropoiesis Under Hepcidin Mimetic Treatment (PN23114) Improved Disease Parameters in a Mouse Model for Sickle Cell Disease by Taranath, Roopa, Zhao, Li, Bourne, Gregory, Bhatt, Ramesh R, Plevy, Scott, Liu, David Y, Bhandari, Ashok

“…Sickle Cell Disease (SCD) is an inherited hemolytic disorder that results from a single point mutation in the hemoglobin-beta (HBB) gene that encodes for the…”
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Indole-based heterocyclic inhibitors of p38α MAP kinase: designing a conformationally restricted analogue by Mavunkel, Babu J, Chakravarty, Sarvajit, Perumattam, John J, Luedtke, Gregory R, Liang, Xi, Lim, Don, Xu, Yong-jin, Laney, Maureen, Liu, David Y, Schreiner, George F, Lewicki, John A, Dugar, Sundeep

“…p38α Mitogen Activated Protein Kinase (MAP kinase) is an intracellular soluble serine threonine kinase. p38α kinase is activated in response to cellular…”
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Tu1244 PN-943, AN ORAL α4β7 INTEGRIN ANTAGONIST, INHIBITS MADCAM1-MEDIATED PROLIFERATION AND CYTOKINE RELEASE FROM CD4+ T-CELLS INDEPENDENT OF TRAFFICKING by Cheng, Xiaoli L., Venkataraman, Sarayu, Zhao, Li, Lee, Lawrence, Tang, Tenny, Liu, David Y., Mattheakis, Larry

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