Search Results - "Liu, Changnian"

Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model by Yue, Eddy W, Douty, Brent, Wayland, Brian, Bower, Michael, Liu, Xiangdong, Leffet, Lynn, Wang, Qian, Bowman, Kevin J, Hansbury, Michael J, Liu, Changnian, Wei, Min, Li, Yanlong, Wynn, Richard, Burn, Timothy C, Koblish, Holly K, Fridman, Jordan S, Metcalf, Brian, Scherle, Peggy A, Combs, Andrew P

“…A hydroxyamidine chemotype has been discovered as a key pharmacophore in novel inhibitors of indoleamine 2,3-dioxygenase (IDO). Optimization led to the…”
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Variations in Mating and Reproduction in Oriental Fruit Moth Caused by Adult Physiological State in Laboratory Tests by Kong, Weina, Wang, Yi, Li, Na, Cao, Weiye, Hu, Xuefeng, Liu, Changnian, Niu, Guofei, Li, Jie, Ma, Ruiyan

“…(Busck) is a pest of rosaceous fruit plants worldwide. Due to a combination of monandry and promiscuity in , the age and mating history of both sexes…”
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Hierarchical data synchronous interaction in nonlinear complex systems by Yuan, Lufeng, Gao, Shijie, He, Xin, Liu, Changnian, Ren, Xilei, Fan, Zhichao

“…Nonlinear complex systems are widely used in various industries, and the complexity and dynamism of the systems pose enormous challenges to data…”
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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer by Zhou, Bin-Bing S., Peyton, Michael, He, Biao, Liu, Changnian, Girard, Luc, Caudler, Eian, Lo, Yvonne, Baribaud, Frederic, Mikami, Iwao, Reguart, Noemi, Yang, Gengjie, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Gazdar, Adi F., Friedman, Steven M., Jablons, David M., Newton, Robert C., Fridman, Jordan S., Minna, John D., Scherle, Peggy A.

“…We describe here the existence of a heregulin-HER3 autocrine loop, and the contribution of heregulin-dependent, HER2-mediated HER3 activation to gefitinib…”
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Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab by Liu, Xiangdong, Fridman, Jordan S., Wang, Qian, Caulder, Eian, Yang, Gengjie, Covington, Maryanne, Liu, Changnian, Marando, Cindy, Zhuo, Jincong, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Newton, Robert C., Scherle, Peggy A., Friedman, Steven M.

“…The HER-2 receptor tyrosine kinase is an important regulator of cell proliferation and survival, and it is a clinically validated target of therapeutic…”
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Discovery of a Potent, Selective, and Orally Active Human Epidermal Growth Factor Receptor-2 Sheddase Inhibitor for the Treatment of Cancer by Yao, Wenqing, Zhuo, Jincong, Burns, David M, Xu, Meizhong, Zhang, Colin, Li, Yun-Long, Qian, Ding-Quan, He, Chunhong, Weng, Lingkai, Shi, Eric, Lin, Qiyan, Agrios, Costas, Burn, Timothy C, Caulder, Eian, Covington, Maryanne B, Fridman, Jordan S, Friedman, Steven, Katiyar, Kamna, Hollis, Gregory, Li, Yanlong, Liu, Changnian, Liu, Xiangdong, Marando, Cindy A, Newton, Robert, Pan, Max, Scherle, Peggy, Taylor, Nancy, Vaddi, Kris, Wasserman, Zelda R, Wynn, Richard, Yeleswaram, Swamy, Jalluri, Ravi, Bower, Michael, Zhou, Bing-Bing, Metcalf, Brian

“…The design, synthesis, evaluation, and identification of a novel class of (6S,7S)-N-hydroxy-6-carboxamide-5-azaspiro[2.5]octane-7-carboxamides as the first…”
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Effect of pre-treatments and frying conditions on the formation of starch-lipid complex in potato starch chips during deep-frying process by Li, Yancai, Zhu, Jiabin, Liu, Changnian, Wang, Yuanyuan, Su, Caihong, Gao, Yuan, Li, Qi, Yu, Xiuzhu

“…This study examined the influence of various pretreatment methods, frying durations, and temperatures, as well as the type of frying oil, on the formation and…”
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Abstract 4178: ETH-155008, a dual inhibitor of CDK and Pim in preclinical treatment of human B-cell lymphoma xenografts by Liu, Changnian, Sun, Zuopeng, Xu, Chunping, Zhang, Pan, Ji, Bin, Zhang, James, Liu, Laura, Yu, Chengzhi

“…Abstract Non-Hodgkin lymphomas (NHLs) are the most common hematologic malignancies. The treatment of lymphoma presents a challenge in clinical oncology…”
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Enhancement of the selectivity and antitumor efficacy of a CC-1065 analogue through immunoconjugate formation by CHARI, R. V. J, JACKEL, K. A, BOURRET, L. A, DERR, S. M, TADAYONI, B. M, MATTOCKS, K. M, SHAH, S.A, CHANGNIAN LIU, BLÄTTLER, W. A, GOLDMACHER, V. S

“…Bis-indolyl-(seco)-1,2,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e compounds are synthetic analogues of CC-1065 that are highly cytotoxic toward a broad…”
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Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts by Liu, Changnian, Willingham, Mark, Liu, Jinqian, Gmeiner, William H

“…Thymidylate synthase (TS) is the molecular target of fluoropyrimidine (FP) chemotherapy, and novel anticancer drugs effective against TS-overexpressing tumors…”
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ETH-155008, a Novel Selective Dual Inhibitor of FLT3 and CDK4/6 in Preclinical Treatment of Acute Myeloid Leukemia by Liu, Changnian, Liu, Bin, Xu, Chunping, Zhang, Pan, Li, Bin, Ji, Bin, Zhang, Bin, Liu, Qingjun, Zhang, James, Yu, Chengzhi

“…▪ Fms-like tyrosine kinase 3 (FLT3) is part of a family of receptor tyrosine kinases (RTKs), and a molecular therapeutic target of acute myeloid leukemia…”
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QoS Multicast Routing Based on Firefly Algorithm by Jie Yuan, Yafei Tian, Shan Wang, Changnian Liu

“…QoS multicast routing problem is a nonlinear combination optimization problem, which is difficult to get the global solution by using the traditional…”
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Adaptive Firefly Optimization Algorithm Based on Stochastic Inertia Weight by Changnian Liu, Yafei Tian, Qiang Zhang, Jie Yuan, Binbin Xue

“…Firefly Algorithm (FA) originates from the swarm behavior which is inspired by natural fireflies through the fluorescence to exchange information. As a novel…”
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A New Extreme Learning Machine Optimized by Firefly Algorithm by Qiang Zhang, Hongxin Li, Changnian Liu, Wei Hu

“…Extreme learning machine (ELM) is a new type of feed forward neural network. Compared with traditional single hidden layer feed forward neural networks, ELM…”
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Semi-blind Channel Estimation of MIMO-OFDM System Based on Extreme Learning Machine by Ling Yang, Binbin Xue, Mingming Nie, Changnian Liu, Qiang Zhang

“…In this paper, a novel semi-blind channel estimate method is proposed for a multi-input multi-output orthogonal frequency division multiplexing (MIMO-OFDM)…”
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Anti-B4-Blocked Ricin Synergizes With Doxorubicin and Etoposide on Multidrug-Resistant and Drug-Sensitive Tumors by O’Connor, Rosemary, Liu, Changnian, Ferris, Cynthia A., Guild, Braydon C., Teicher, Beverly A., Corvi, Christopher, Liu, Yimao, Arceci, Robert J., Goldmacher, Victor S., Lambert, John M., Blättler, Walter A.

“…Anti-B4–blocked ricin (anti-B4–bR) is an immunotoxin directed against CD19-positive cells that is currently being tested in several B-cell leukemia/lymphoma…”
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Abstract 327: Establishment of patient primary ovarian cancer xenograft models for test of anticancer agents by Liu, Changnian, Xu, Chunping, Li, Wenwei, Zhou, Wen, Liu, Yong, Zhou, Rui, Zhang, Ning

“…Abstract BACKGROUND Human xenograft tumor models established by transplantation of human tumor cell lines into immunodifficient mice have been routinely used…”
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Abstract 2777: Advantages of patient primary tumor models versus tumor cell lines derived models for testing anticancer therapeutics by Liu, Changnian, Li, Wenwei, Zhou, Wen, Liu, Rong, Zhou, Rui, He, Fang, Xu, Chunping, Bai, Chang

“…Abstract BACKGROUND While the tumor xenograft models derived from human cancer cell lines in immunodeficient mice have been widely used for testing cytotoxic…”
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Abstract 2776: Establishment of patient non-small cell lung cancer derived models for test of anticancer drugs by Liu, Changnian, Sun, Connie, Li, Wenwei, Zhou, Wen, Liu, Yong, Zhou, Rui, He, Fang, Bai, Chang

“…Abstract BACKGROUND Human tumor xenograft models established by transplantation of human tumor cell lines into immunodifficient mice have been routinely used…”
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Abstract 2775: Establishment of patient primary gastric cancer xenograft models for test of anticancer agents by Zhang, Ning, You, Shengyi, Li, Wenwei, Zhou, Wen, Liu, Yong, Zhou, Rui, He, Fang, Liu, Changnian

“…Abstract Background. Human xenograft tumor models established by inoculating human tumor cell lines into immunodifficient mice have been routinely used for…”
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