Search Results - "Liu, Cassie J"

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis by Zainabadi, Kayvan, Liu, Cassie J, Caldwell, Alison L M, Guarente, Leonard

“…Overexpression or pharmacological activation of SIRT1 has been shown to extend the lifespan of mice and protect against aging-related diseases. Here we show…”
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SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2 by Zainabadi, Kayvan, Liu, Cassie J, Guarente, Leonard

“…Activation of SIRT1 has previously been shown to protect mice against osteoporosis through yet ill-defined mechanisms. In this study, we outline a role for…”
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Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction by Sonnenberg, Sonya B, Rane, Aboli A, Liu, Cassie J, Rao, Nikhil, Agmon, Gillie, Suarez, Sophia, Wang, Raymond, Munoz, Adam, Bajaj, Vaibhav, Zhang, Shirley, Braden, Rebecca, Schup-Magoffin, Pamela J, Kwan, Oi Ling, DeMaria, Anthony N, Cochran, Jennifer R, Christman, Karen L

“…Abstract Hepatocyte growth factor (HGF) has been shown to have anti-fibrotic, pro-angiogenic, and cardioprotective effects; however, it is highly unstable and…”
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An engineered dimeric fragment of hepatocyte growth factor is a potent c-MET agonist by Liu, Cassie J., Jones, Douglas S., Tsai, Ping-Chuan, Venkataramana, Abhishek, Cochran, Jennifer R.

“…•HGF is difficult to produce and unstable, highlighting a need for c-MET agonists.•A disulfide-linked dimer (eNK1 dimer) was created from an engineered HGF…”
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Engineering Bivalency and Bispecificity in Protein Therapeutics and Protein Scaffold Development by Liu, Cassie J

“…Multivalent and multifunctional proteins are abundant in nature. The avidity effect, a core principle of multivalent molecules, allows these proteins to tune…”
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