Search Results - "Liu, Annie X"

yeast functional screen predicts new candidate ALS disease genes by Couthouis, Julien, Hart, Michael P, Shorter, James, DeJesus-Hernandez, Mariely, Erion, Renske, Oristano, Rachel, Liu, Annie X, Ramos, Daniel, Jethava, Niti, Hosangadi, Divya, Epstein, James, Chiang, Ashley, Diaz, Zamia, Nakaya, Tadashi, Ibrahim, Fadia, Kim, Hyung-Jun, Solski, Jennifer A, Williams, Kelly L, Mojsilovic-Petrovic, Jelena, Ingre, Caroline, Boylan, Kevin, Graff-Radford, Neill R, Dickson, Dennis W, Clay-Falcone, Dana, Elman, Lauren, McCluskey, Leo, Greene, Robert, Kalb, Robert G, Lee, Virginia M.-Y, Trojanowski, John Q, Ludolph, Albert, Robberecht, Wim, Andersen, Peter M, Nicholson, Garth A, Blair, Ian P, King, Oliver D, Bonini, Nancy M, Van Deerlin, Vivianna, Rademakers, Rosa, Mourelatos, Zissimos, Gitler, Aaron D

“…Amyotrophic lateral sclerosis (ALS) is a devastating and universally fatal neurodegenerative disease. Mutations in two related RNA-binding proteins, TDP-43 and…”
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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction by Blevitt, Jonathan M, Hack, Michael D, Herman, Krystal L, Jackson, Paul F, Krawczuk, Paul J, Lebsack, Alec D, Liu, Annie X, Mirzadegan, Taraneh, Nelen, Marina I, Patrick, Aaron N, Steinbacher, Stefan, Milla, Marcos E, Lumb, Kevin J

“…A prevalent observation in high-throughput screening and drug discovery programs is the inhibition of protein function by small-molecule compound aggregation…”
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Detection of Small-Molecule Aggregation with High-Throughput Microplate Biophysical Methods by Allen, Samantha J, Dower, Corey M, Liu, Annie X, Lumb, Kevin J

“…Small-molecule drug discovery can be hindered by the formation of aggregates that act as non-selective inhibitors of drug targets. Such aggregates appear as…”
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