Search Results - "Liu, Andrew C"

Translational Control of Entrainment and Synchrony of the Suprachiasmatic Circadian Clock by mTOR/4E-BP1 Signaling by Cao, Ruifeng, Robinson, Barry, Xu, Haiyan, Gkogkas, Christos, Khoutorsky, Arkady, Alain, Tommy, Yanagiya, Akiko, Nevarko, Tatiana, Liu, Andrew C., Amir, Shimon, Sonenberg, Nahum

“…Protein synthesis is critical for circadian clock function, but little is known of how translational regulation controls the master pacemaker in mammals, the…”
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mTOR signaling regulates central and peripheral circadian clock function by Ramanathan, Chidambaram, Kathale, Nimish D, Liu, Dong, Lee, Choogon, Freeman, David A, Hogenesch, John B, Cao, Ruifeng, Liu, Andrew C

“…The circadian clock coordinates physiology and metabolism. mTOR (mammalian/mechanistic target of rapamycin) is a major intracellular sensor that integrates…”
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NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1 by Shen, Yang, Endale, Mehari, Wang, Wei, Morris, Andrew R, Francey, Lauren J, Harold, Rachel L, Hammers, David W, Huo, Zhiguang, Partch, Carrie L, Hogenesch, John B, Wu, Zhao-Hui, Liu, Andrew C

“…In mammals, the circadian clock coordinates cell physiological processes including inflammation. Recent studies suggested a crosstalk between these two…”
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Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis by Montminy, Marc, Hirota, Tsuyoshi, Pongsawakul, Pagkapol Y, Liu, Andrew C, Sun, Xiujie, Nusinow, Dmitri A, Brenner, David A, Zhang, Eric E, Landais, Severine, Dentin, Renaud, Kodama, Yuzo, Kay, Steve A, Liu, Yi

“…During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two…”
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PSMD11 modulates circadian clock function through PER and CRY nuclear translocation by Cal-Kayitmazbatir, Sibel, Francey, Lauren J, Lee, Yool, Liu, Andrew C, Hogenesch, John B

“…The molecular circadian clock is regulated by a transcriptional translational feedback loop. However, the post-translational control mechanisms are less…”
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NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus by Wible, Ryan S, Ramanathan, Chidambaram, Sutter, Carrie Hayes, Olesen, Kristin M, Kensler, Thomas W, Liu, Andrew C, Sutter, Thomas R

“…Diurnal oscillation of intracellular redox potential is known to couple metabolism with the circadian clock, yet the responsible mechanisms are not well…”
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Delay in Feedback Repression by Cryptochrome 1 Is Required for Circadian Clock Function by Ukai-Tadenuma, Maki, Yamada, Rikuhiro G., Xu, Haiyan, Ripperger, Jürgen A., Liu, Andrew C., Ueda, Hiroki R.

“…Direct evidence for the requirement of delay in feedback repression in the mammalian circadian clock has been elusive. Cryptochrome 1 ( Cry1), an essential…”
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Cell type-specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock models by Ramanathan, Chidambaram, Xu, Haiyan, Khan, Sanjoy K, Shen, Yang, Gitis, Paula J, Welsh, David K, Hogenesch, John B, Liu, Andrew C

“…In animals, circadian rhythms in physiology and behavior result from coherent rhythmic interactions between clocks in the brain and those throughout the body…”
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Kava as a Clinical Nutrient: Promises and Challenges by Bian, Tengfei, Corral, Pedro, Wang, Yuzhi, Botello, Jordy, Kingston, Rick, Daniels, Tyler, Salloum, Ramzi G, Johnston, Edward, Huo, Zhiguang, Lu, Junxuan, Liu, Andrew C, Xing, Chengguo

“…Kava beverages are typically prepared from the root of Piper methysticum. They have been consumed among Pacific Islanders for centuries. Kava extract…”
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Emergence of noise-induced oscillations in the central circadian pacemaker by Ko, Caroline H, Yamada, Yujiro R, Welsh, David K, Buhr, Ethan D, Liu, Andrew C, Zhang, Eric E, Ralph, Martin R, Kay, Steve A, Forger, Daniel B, Takahashi, Joseph S

“…Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null…”
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chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β by Hirota, Tsuyoshi, Lewis, Warren G, Liu, Andrew C, Lee, Jae Wook, Schultz, Peter G, Kay, Steve A

“…The circadian clock controls daily oscillations of gene expression at the cellular level. We report the development of a high-throughput circadian functional…”
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A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells by Zhang, Eric E., Liu, Andrew C., Hirota, Tsuyoshi, Miraglia, Loren J., Welch, Genevieve, Pongsawakul, Pagkapol Y., Liu, Xianzhong, Atwood, Ann, Huss, Jon W., Janes, Jeff, Su, Andrew I., Hogenesch, John B., Kay, Steve A.

“…Two decades of research identified more than a dozen clock genes and defined a biochemical feedback mechanism of circadian oscillator function. To identify…”
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Light-regulated translational control of circadian behavior by eIF4E phosphorylation by Cao, Ruifeng, Gkogkas, Christos G, de Zavalia, Nuria, Blum, Ian D, Yanagiya, Akiko, Tsukumo, Yoshinori, Xu, Haiyan, Lee, Choogon, Storch, Kai-Florian, Liu, Andrew C, Amir, Shimon, Sonenberg, Nahum

“…Light controls animal circadian behavior by regulating gene expression in the circadian clock. Here, Cao et al. reports that a light-activated MAPK/MNK pathway…”
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A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms by Gustafson, Chelsea L., Parsley, Nicole C., Asimgil, Hande, Lee, Hsiau-Wei, Ahlbach, Christopher, Michael, Alicia K., Xu, Haiyan, Williams, Owen L., Davis, Tara L., Liu, Andrew C., Partch, Carrie L.

“…The C-terminal transactivation domain (TAD) of BMAL1 (brain and muscle ARNT-like 1) is a regulatory hub for transcriptional coactivators and repressors that…”
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Machine learning helps identify CHRONO as a circadian clock component by Anafi, Ron C, Lee, Yool, Sato, Trey K, Venkataraman, Anand, Ramanathan, Chidambaram, Kavakli, Ibrahim H, Hughes, Michael E, Baggs, Julie E, Growe, Jacqueline, Liu, Andrew C, Kim, Junhyong, Hogenesch, John B

“…Over the last decades, researchers have characterized a set of "clock genes" that drive daily rhythms in physiology and behavior. This arduous work has yielded…”
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The NRON complex controls circadian clock function through regulated PER and CRY nuclear translocation by Lee, Yool, Shen, Yang, Francey, Lauren J., Ramanathan, Chidambaram, Sehgal, Amita, Liu, Andrew C., Hogenesch, John B.

“…Post-translational regulation plays a central role in the circadian clock mechanism. However, nucleocytoplasmic translocation of core clock proteins, a key…”
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Bioluminescence Imaging of Individual Fibroblasts Reveals Persistent, Independently Phased Circadian Rhythms of Clock Gene Expression by Welsh, David K., Yoo, Seung-Hee, Liu, Andrew C., Takahashi, Joseph S., Kay, Steve A.

“…Circadian (ca. 24 hr) oscillations in expression of mammalian “clock genes” are found not only in the suprachiasmatic nucleus (SCN), the central circadian…”
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model of the cell-autonomous mammalian circadian clock by Mirsky, Henry P, Liu, Andrew C, Welsh, David K, Kay, Steve A, Doyle, Francis J. III

“…Circadian timekeeping by intracellular molecular clocks is evident widely in prokaryotes and eukaryotes. The clockworks are driven by autoregulatory feedback…”
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Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network by Liu, Andrew C., Welsh, David K., Ko, Caroline H., Tran, Hien G., Zhang, Eric E., Priest, Aaron A., Buhr, Ethan D., Singer, Oded, Meeker, Kirsten, Verma, Inder M., Doyle, Francis J., Takahashi, Joseph S., Kay, Steve A.

“…Molecular mechanisms of the mammalian circadian clock have been studied primarily by genetic perturbation and behavioral analysis. Here, we used…”
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Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function by Khan, Sanjoy K., Xu, Haiyan, Ukai-Tadenuma, Maki, Burton, Brittany, Wang, Yongmei, Ueda, Hiroki R., Liu, Andrew C.

“…Background: Mammalian CRY1 and CRY2 have distinct functions in circadian clock mechanisms. Results: A core domain within the photolyase homology region of CRY1…”
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