Search Results - "Litwin, Samuel"

HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant by Mason, William S, Gill, Upkar S, Litwin, Samuel, Zhou, Yan, Peri, Suraj, Pop, Oltin, Hong, Michelle L.W, Naik, Sandhia, Quaglia, Alberto, Bertoletti, Antonio, Kennedy, Patrick T.F

“…Abstract Background & Aims Chronic infection with hepatitis B virus (HBV) progresses through different phases. The first, called the immune-tolerant phase, has…”
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Hepatitis B Virus DNA Integration and Clonal Expansion of Hepatocytes in the Chronically Infected Liver by Mason, William S, Jilbert, Allison R, Litwin, Samuel

“…Human hepatitis B virus (HBV) can cause chronic, lifelong infection of the liver that may lead to persistent or episodic immune-mediated inflammation against…”
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Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma by JINFEI XU, KADARIYA, Yuwaraj, HONGZHUANG PENG, KARAR, Jayashree, RAUSCHER, Frank J, TESTA, Joseph R, CHEUNG, Mitchell, JIANMING PEI, TALARCHEK, Jacqueline, SEMENTINO, Eleonora, YINFEI TAN, MENGES, Craig W, CAI, Kathy Q, LITWIN, Samuel

“…Malignant mesotheliomas are highly aggressive tumors usually caused by exposure to asbestos. Germline-inactivating mutations of BAP1 predispose to mesothelioma…”
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OER‐073: A multicenter phase 2 study evaluating the role of pazopanib in angiosarcoma by Thiebaud, Julio Alvarenga, Ravi, Vinod, Litwin, Samuel, Schuetze, Scott M., Movva, Sujana, Agulnik, Mark, Kraft, Andrew S., Tetzlaff, Eric D., Somaiah, Neeta, Mehren, Margaret

“…Background Angiosarcomas are rare mesenchymal sarcomas that can present as primary cutaneous or noncutaneous disease. They express a variety of vascular…”
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Phase II Trial of Cetuximab With or Without Paclitaxel in Patients With Advanced Urothelial Tract Carcinoma by WONG, Yu-Ning, LITWIN, Samuel, HUDES, Gary, VAUGHN, David, COHEN, Seth, PLIMACK, Elizabeth R, LEE, James, SONG, Wei, DABROW, Michael, BRODY, Marion, TUTTLE, Holly

“…The benefit of salvage chemotherapy is modest in metastatic urothelial cancer. We conducted a randomized, noncomparative phase II study to measure the efficacy…”
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Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study by von Mehren, Margaret, George, Suzanne, Heinrich, Michael C, Schuetze, Scott M, Yap, Jeffrey T, Yu, Jain Q, Abbott, Amanda, Litwin, Samuel, Crowley, John, Belinsky, Martin, Janeway, Katherine A, Hornick, Jason L, Flieder, Douglas B, Chugh, Rashmi, Rink, Lori, Van den Abbeele, Annick D

“…Most gastrointestinal stromal tumors (GIST) have activating mutations of , or uncommonly . Fifteen percent of adult and 85% of pediatric GISTs are wild type…”
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Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth by Gritsina, Galina, Xiao, Fang, O'Brien, Shane W, Gabbasov, Rashid, Maglaty, Marisa A, Xu, Ren-Huan, Thapa, Roshan J, Zhou, Yan, Nicolas, Emmanuelle, Litwin, Samuel, Balachandran, Siddharth, Sigal, Luis J, Huszar, Dennis, Connolly, Denise C

“…Ovarian carcinoma is the fifth leading cause of death among women in the United States. Persistent activation of STAT3 is frequently detected in ovarian…”
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Clonal Expansion of Normal-Appearing Human Hepatocytes during Chronic Hepatitis B Virus Infection by Mason, William S, Liu, Chen, Aldrich, Carol E, Litwin, Samuel, Yeh, Matthew M

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Immune Tolerant Chronic Hepatitis B: The Unrecognized Risks by Kennedy, Patrick T F, Litwin, Samuel, Dolman, Grace E, Bertoletti, Antonio, Mason, William S

“…Chronic infection with hepatitis B virus (HBV) progresses through multiple phases, including immune tolerant, immune active, immune control, and, in a subset…”
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NK cell dysfunction in chronic lymphocytic leukemia is associated with loss of the mature cells expressing inhibitory killer cell Ig-like receptors by MacFarlane, Alexander W., Jillab, Mowafaq, Smith, Mitchell R., Alpaugh, R. Katherine, Cole, Marion E., Litwin, Samuel, Millenson, Michael M., Al-Saleem, Tahseen, Cohen, Adam D., Campbell, Kerry S.

“…A prospective analysis of natural killer (NK) cell phenotype and function was performed on fresh peripheral blood samples from untreated patients with B-cell…”
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RAD001 (everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer by MABUCHI, Seiji, ALTOMARE, Deborah A, CONNOLLY, Denise C, KLEIN-SZANTO, Andres, LITWIN, Samuel, HOELZLE, Matthew K, HENSLEY, Harvey H, HAMILTON, Thomas C, TESTA, Joseph R

“…The mammalian target of rapamycin (mTOR) is thought to play a critical role in regulating cell growth, cell cycle progression, and tumorigenesis. Because the…”
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Duck hepatitis B virus covalently closed circular DNA appears to survive hepatocyte mitosis in the growing liver by Reaiche-Miller, Georget Y, Thorpe, Michael, Low, Huey Chi, Qiao, Qiao, Scougall, Catherine A, Mason, William S, Litwin, Samuel, Jilbert, Allison R

“…Abstract Nucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically used as monotherapy for chronically infected patients…”
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Mechanism for CCC DNA synthesis in hepadnaviruses by Sohn, Ji A, Litwin, Samuel, Seeger, Christoph

“…Hepadnavirus replication requires the synthesis of a covalently closed circular (CCC) DNA from the relaxed circular (RC) viral genome by an unknown mechanism…”
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Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer by Serebriiskii, Ilya G., Pavlov, Valerii A., Andrianov, Grigorii V., Litwin, Samuel, Basickes, Stanley, Newberg, Justin Y., Frampton, Garrett M., Meyer, Joshua E., Golemis, Erica A.

“…Somatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN -inactivating mutations…”
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Genome-Wide Analyses of Avian Sarcoma Virus Integration Sites by NAREZKINA, Anna, TAGANOV, Konstantin D, LITWIN, Samuel, STOYANOVA, Radka, HAYASHI, Junpei, SEEGER, Christoph, SKALKA, Anna Marie, KATZ, Richard A

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Five-year Local Control in a Phase II Study of Hypofractionated Intensity Modulated Radiation Therapy With an Incorporated Boost for Early Stage Breast Cancer by Freedman, Gary M., MD, Anderson, Penny R., MD, Bleicher, Richard J., MD, Litwin, Samuel, PhD, Li, Tianyu, MS, Swaby, Ramona F., MD, Ma, Chang-Ming Charlie, PhD, Li, Jinsheng, PhD, Sigurdson, Elin R., MD, PhD, Watkins-Bruner, Deborah, RN, PhD, Morrow, Monica, MD, Goldstein, Lori J., MD

“…Purpose Conventional radiation fractionation of 1.8-2 Gy per day for early stage breast cancer requires daily treatment for 6-7 weeks. We report the 5-year…”
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Combining anti-ERBB3 antibodies specific for domain I and domain III enhances the anti-tumor activity over the individual monoclonal antibodies by D'Souza, Jimson W, Reddy, Smitha, Goldsmith, Lisa E, Shchaveleva, Irina, Marks, James D, Litwin, Samuel, Robinson, Matthew K

“…Inappropriate signaling through the epidermal growth factor receptor family (EGFR1/ERBB1, ERBB2/HER2, ERBB3/HER3, and ERBB4/HER4) of receptor tyrosine kinases…”
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Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein by Silvers, Robert M, Smith, Johanna A, Schowalter, Michael, Litwin, Samuel, Liang, Zhihui, Geary, Kyla, Daniel, René

“…HIV-1-based lentiviral vectors are a promising tool for gene therapy. However, integration of a lentiviral vector into host cell genes may lead to the…”
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Detection of Clonally Expanded Hepatocytes in Chimpanzees with Chronic Hepatitis B Virus Infection by Mason, William S, Low, Huey-Chi, Xu, Chunxiao, Aldrich, Carol E, Scougall, Catherine A, Grosse, Arend, Clouston, Andrew, Chavez, Deborah, Litwin, Samuel, Peri, Suraj, Jilbert, Allison R, Lanford, Robert E

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Small Cell Carcinoma of the Bladder: 20-Year Single-Institution Retrospective Review by Jung, Kyungsuk, M.D., M.P.H, Ghatalia, Pooja, M.D, Litwin, Samuel, Ph.D, Horwitz, Eric M., M.D, Uzzo, Robert G., M.D, Greenberg, Richard E., M.D., F.A.C.S, Viterbo, Rosalia, M.D., F.A.C.S, Geynisman, Daniel M., M.D, Kutikov, Alexander, M.D., F.A.C.S, Plimack, Elizabeth, M.D., M.S, Smaldone, Marc C., M.D., M.S.H.P, Wong, Yu-Ning, M.D., M.S.C.E, Bilusic, Marijo, M.D., Ph.D

“…Abstract Introduction Small cell carcinoma of the bladder is a poorly differentiated neoplasm with aggressive behavior. We analyzed clinical outcomes of…”
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