Search Results - "Litvinov, Rustem I."

Mechanisms of fibrin polymerization and clinical implications by Weisel, John W., Litvinov, Rustem I.

“…Research on all stages of fibrin polymerization, using a variety of approaches including naturally occurring and recombinant variants of fibrinogen, x-ray…”
Get full text

Quantitative structural mechanobiology of platelet-driven blood clot contraction by Kim, Oleg V., Litvinov, Rustem I., Alber, Mark S., Weisel, John W.

“…Blood clot contraction plays an important role in prevention of bleeding and in thrombotic disorders. Here, we unveil and quantify the structural mechanisms of…”
Get full text

The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli by Chernysh, Irina N., Nagaswami, Chandrasekaran, Kosolapova, Sofia, Peshkova, Alina D., Cuker, Adam, Cines, Douglas B., Cambor, Carolyn L., Litvinov, Rustem I., Weisel, John W.

“…Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how…”
Get full text

The α-Helix to β-Sheet Transition in Stretched and Compressed Hydrated Fibrin Clots by Litvinov, Rustem I., Faizullin, Dzhigangir A., Zuev, Yuriy F., Weisel, John W.

“…Fibrin is a protein polymer that forms the viscoelastic scaffold of blood clots and thrombi. Despite the critical importance of fibrin deformability for…”
Get full text

Structural basis for the nonlinear mechanics of fibrin networks under compression by Kim, Oleg V, Litvinov, Rustem I, Weisel, John W, Alber, Mark S

“…Abstract Fibrin is a protein polymer that forms a 3D filamentous network, a major structural component of protective physiological blood clots as well as life…”
Get full text

Atomic Structural Models of Fibrin Oligomers by Zhmurov, Artem, Protopopova, Anna D., Litvinov, Rustem I., Zhukov, Pavel, Weisel, John W., Barsegov, Valeri

“…The space-filling fibrin network is a major part of clots and thrombi formed in blood. Fibrin polymerization starts when fibrinogen, a plasma protein, is…”
Get full text

Circulating Microparticles Alter Formation, Structure and Properties of Fibrin Clots by Zubairova, Laily D., Nabiullina, Roza M., Nagaswami, Chandrasekaran, Zuev, Yuriy F., Mustafin, Ilshat G., Litvinov, Rustem I., Weisel, John W.

“…Despite the importance of circulating microparticles in haemostasis and thrombosis, there is limited evidence for potential causative effects of naturally…”
Get full text

Altered platelet and coagulation function in moderate-to-severe COVID-19 by Litvinov, Rustem I., Evtugina, Natalia G., Peshkova, Alina D., Safiullina, Svetlana I., Andrianova, Izabella A., Khabirova, Alina I., Nagaswami, Chandrasekaran, Khismatullin, Rafael R., Sannikova, Svetlana S., Weisel, John W.

“…To reveal if coagulopathies relate to the course of COVID-19, we examined 255 patients with moderate and severe COVID-19, receiving anticoagulants and…”
Get full text

Visualizing thrombosis to improve thrombus resolution by Weisel, John W., Litvinov, Rustem I.

“…The severity, course, and outcomes of thrombosis are determined mainly by the size and location of the thrombus, but studying thrombus structure and…”
Get full text

Impaired contraction of blood clots as a novel prothrombotic mechanism in systemic lupus erythematosus by Le Minh, Giang, Peshkova, Alina D, Andrianova, Izabella A, Sibgatullin, Timur B, Maksudova, Adelia N, Weisel, John W, Litvinov, Rustem I

“…The aim of this work was to examine a possible role of clot contraction/retraction in thrombotic complications of systemic lupus erythematosus (SLE). Using a…”
Get more information

Use of electron microscopy to study platelets and thrombi by Tomaiuolo, Maurizio, Litvinov, Rustem I., Weisel, John W., Stalker, Timothy J.

“…Electron microscopy has been a valuable tool for the study of platelet biology and thrombosis for more than 70 years. Early studies using conventional…”
Get full text

Accelerated Spatial Fibrin Growth and Impaired Contraction of Blood Clots in Patients with Rheumatoid Arthritis by Peshkova, Alina D, Evdokimova, Tatiana A, Sibgatullin, Timur B, Ataullakhanov, Fazoil I, Litvinov, Rustem I, Weisel, John W

“…Rheumatoid arthritis (RA) is an autoimmune disease associated with thrombotic complications. To elucidate pathogenic mechanisms, hemostatic disorders in RA…”
Get full text

Mechanism of Fibrin(ogen) Forced Unfolding by Zhmurov, Artem, Brown, Andre E.X., Litvinov, Rustem I., Dima, Ruxandra I., Weisel, John W., Barsegov, Valeri

“…Fibrinogen, upon enzymatic conversion to monomeric fibrin, provides the building blocks for fibrin polymer, the scaffold of blood clots and thrombi. Little has…”
Get full text

Fatal dysfunction and disintegration of thrombin-stimulated platelets by Kim, Oleg V, Nevzorova, Tatiana A, Mordakhanova, Elmira R, Ponomareva, Anastasia A, Andrianova, Izabella A, Le Minh, Giang, Daminova, Amina G, Peshkova, Alina D, Alber, Mark S, Vagin, Olga, Litvinov, Rustem I, Weisel, John W

“…Platelets play a key role in the formation of hemostatic clots and obstructive thrombi as well as in other biological processes. In response to physiological…”
Get full text

A familial case of MYH9 gene mutation associated with multiple functional and structural platelet abnormalities by Safiullina, Svetlana I., Evtugina, Natalia G., Andrianova, Izabella A., Khismatullin, Rafael R., Kravtsova, Olga A., Khabirova, Alina I., Nagaswami, Chandrasekaran, Daminova, Amina G., Peshkova, Alina D., Litvinov, Rustem I., Weisel, John W.

“…Mutations in the MYH9 gene result in macrothrombocytopenia often associated with hemorrhages. Here, we studied the function and structure of platelets in three…”
Get full text

Structural Basis of Interfacial Flexibility in Fibrin Oligomers by Zhmurov, Artem, Protopopova, Anna D., Litvinov, Rustem I., Zhukov, Pavel, Mukhitov, Alexander R., Weisel, John W., Barsegov, Valeri

“…Fibrin is a filamentous network made in blood to stem bleeding; it forms when fibrinogen is converted into fibrin monomers that self-associate into oligomers…”
Get full text

Chronic Immune Platelet Activation Is Followed by Platelet Refractoriness and Impaired Contractility by Andrianova, Izabella A., Khabirova, Alina I., Ponomareva, Anastasia A., Peshkova, Alina D., Evtugina, Natalia G., Le Minh, Giang, Sibgatullin, Timur B., Weisel, John W., Litvinov, Rustem I.

“…Autoimmune diseases, including systemic lupus erythematosus (SLE), have a high risk of thrombotic and hemorrhagic complications associated with altered…”
Get full text

Activated Monocytes Enhance Platelet-Driven Contraction of Blood Clots via Tissue Factor Expression by Peshkova, Alina D., Le Minh, Giang, Tutwiler, Valerie, Andrianova, Izabella A., Weisel, John W., Litvinov, Rustem I.

“…Platelet-driven reduction in blood clot volume (clot contraction or retraction) has been implicated to play a role in hemostasis and thrombosis. Although these…”
Get full text

Platelet Activation in Heparin-Induced Thrombocytopenia is Followed by Platelet Death via Complex Apoptotic and Non-Apoptotic Pathways by Mordakhanova, Elmira R, Nevzorova, Tatiana A, Synbulatova, Gulnaz E, Rauova, Lubica, Weisel, John W, Litvinov, Rustem I

“…Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by thrombocytopenia and a high risk for venous or arterial thrombosis. HIT is…”
Get full text

Lytic Susceptibility, Structure, and Mechanical Properties of Fibrin in Systemic Lupus Erythematosus by Litvinov, Rustem I, Nabiullina, Rosa M, Zubairova, Laily D, Shakurova, Mileusha A, Andrianova, Izabella A, Weisel, John W

“…Among complications of systemic lupus erythematosus (SLE), thrombotic events are relatively common and contribute significantly to the morbidity and mortality…”
Get full text