Search Results - "Litvak, Joane"

Synthesis of 3,5-disubstituted-1,2,4-oxadiazoles using tetrabutylammonium fluoride as a mild and efficient catalyst by Gangloff, Anthony R, Litvak, Joane, Shelton, Emma J, Sperandio, David, Wang, Vivian R, Rice, Kenneth D

“…Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. Using 0.1–1.0…”
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Ethnobotanical-Directed Discovery of the Antihyperglycemic Properties of Cryptolepine: Its Isolation from Cryptolepis sanguinolenta, Synthesis, and in Vitro and in Vivo Activities by Bierer, Donald E, Fort, Diana M, Mendez, Christopher D, Luo, Jian, Imbach, Patricia A, Dubenko, Larisa G, Jolad, Shivanand D, Gerber, R. Eric, Litvak, Joane, Lu, Qing, Zhang, Pingsheng, Reed, Michael J, Waldeck, Nancy, Bruening, Reimar C, Noamesi, Ben K, Hector, Richard F, Carlson, Thomas J, King, Steven R

“…Using an ethnobotanical approach in combination with in vivo-guided fractionation as a means for lead discovery, cryptolepine was isolated as an…”
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Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2 H-pyran-3-yl)-7-phenyl-( E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay by Drewe, John, Kasibhatla, Shailaja, Tseng, Ben, Shelton, Emma, Sperandio, David, Yee, Robert M., Litvak, Joane, Sendzik, Martin, Spencer, Jeffrey R., Cai, Sui Xiong

“…The discovery and SAR studies of 5-(4-hydroxy-6-methyl-2-oxo-2 H-pyran-3-yl)-7-phenyl-( E)-2,3,6,7-tetrahydro-1,4-thiazepines as a novel series of apoptosis…”
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A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site by Katz, Bradley A, Elrod, Kyle, Luong, Christine, Rice, Mark J, Mackman, Richard L, Sprengeler, Paul A, Spencer, Jeffrey, Hataye, Jason, Janc, James, Link, John, Litvak, Joane, Rai, Roopa, Rice, Ken, Sideris, Steve, Verner, Erik, Young, Wendy

“…We describe a new serine protease inhibition motif in which binding is mediated by a cluster of very short hydrogen bonds (<2.3 Å) at the active site. This…”
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Discovery and structure–activity relationship of 2-phenyl-oxazole-4-carboxamide derivatives as potent apoptosis inducers by Tai, Vincent W.-F., Sperandio, David, Shelton, Emma J., Litvak, Joane, Pararajasingham, Keith, Cebon, Ben, Lohman, Julia, Eksterowicz, John, Kantak, Seema, Sabbatini, Peter, Brown, Cindy, Zeitz, Jennifer, Reed, Chris, Maske, Bill, Graupe, Doris, Estevez, Alberto, Oeh, Jason, Wong, Darren, Ni, Yong, Sprengeler, Paul, Yee, Robert, Magill, Catherine, Neri, Anthony, Cai, Sui Xiong, Drewe, John, Qiu, Ling, Herich, John, Tseng, Ben, Kasibhatla, Shailaja, Spencer, Jeffrey R.

“…Novel 2-phenyl-oxazole-4-carboxamide-containing apoptosis inducers were discovered from a cell-based assay for caspase-3 activation. Synthesis, in vitro, and…”
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Antihyperglycemic Activities of Cryptolepine Analogues:  An Ethnobotanical Lead Structure Isolated from Cryptolepis sanguinolenta by Bierer, Donald E, Dubenko, Larisa G, Zhang, Pingsheng, Lu, Qing, Imbach, Patricia A, Garofalo, Albert W, Phuan, Puay-Wah, Fort, Diana M, Litvak, Joane, Gerber, R. Eric, Sloan, Barbara, Luo, Jian, Cooper, Raymond, Reaven, Gerald M

“…Cryptolepine (1) is a rare example of a natural product whose synthesis was reported prior to its isolation from nature. In the previous paper we reported the…”
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Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease by Sperandio, David, Gangloff, Anthony R., Litvak, Joane, Goldsmith, Richard, Hataye, Jason M., Wang, Vivian R., Shelton, Emma J., Elrod, Kyle, Janc, James W., Clark, James M., Rice, Ken, Weinheimer, Steve, Yeung, Kap-Sun, Meanwell, Nicholas A., Hernandez, Dennis, Staab, Andrew J., Venables, Brian L., Spencer, Jeffrey R.

“…Screening of a diverse set of bisbenzimidazoles for inhibition of the hepatitis C virus (HCV) serine protease NS3/NS4A led to the identification of a potent Zn…”
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Isolation and Unambiguous Synthesis of Cryptolepinone:  An Oxidation Artifact of Cryptolepine by Fort, Diana M., Litvak, Joane, Chen, Jian Lu, Lu, Qing, Phuan, Puay-Wah, Cooper, Raymond, Bierer, Donald E.

“…Cryptolepinone (3) was isolated as an artifact of extraction from Cryptolepis sanguinolenta. Previously, this compound had been identified as the natural…”
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Total Synthesis of Cacalol by Garofalo, Albert W, Litvak, Joane, Wang, Lisa, Dubenko, Larisa G, Cooper, Raymond, Bierer, Donald E

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A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site11Edited by D. Rees by Katz, Bradley A, Elrod, Kyle, Luong, Christine, Rice, Mark J, Mackman, Richard L, Sprengeler, Paul A, Spencer, Jeffrey, Hataye, Jason, Janc, James, Link, John, Litvak, Joane, Rai, Roopa, Rice, Ken, Sideris, Steve, Verner, Erik, Young, Wendy

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Novel 1,2-Dithiins: Synthesis, Molecular Modeling Studies, and Antifungal Activity by Bierer, Donald E, Dener, Jeffrey M, Dubenko, Larisa G, Gerber, R. Eric, Litvak, Joane, Peterli, Stefan, Peterli-Roth, Patricia, Truong, Thien V, Mao, Guohua, Bauer, Barr E

“…The first structure-activity study involving the 1,2-dithiin class of compounds (1,2-dithiacyclohexadienes) is herein reported. A series of 3,6-disubstituted…”
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Synthetic Analogues of Irlbacholine:  A Novel Antifungal Plant Metabolite Isolated from Irlbachia Alata by Lu, Qing, Ubillas, Rosa P, Zhou, Yihong, Dubenko, Larisa G, Dener, Jeffrey M, Litvak, Joane, Phuan, Puay-Wah, Flores, Martha, Ye, ZhiJun, Gerber, R. Eric, Truong, Thien, Bierer, Donald E

“…Irlbacholine and a series of related analogues were synthesized and their antifungal activities against Candida albicans, Cryptococcus neoformans, and…”
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Isolation and Unambiguous Synthesis of Cryptolepinone:  An Oxidation Artifact of Cryptolepine by Fort, Diana M., Litvak, Joane, Chen, Jian Lu, Lu, Qing, Phuan, Puay-Wah, Cooper, Raymond, Bierer, Donald E.

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Synthesis of (2R)- and (2S)-.beta.-D-Glucopyranos-1-yl-2-O-palmitoyl-3-O-phosphatidylcholinylglycerol: A New Antifungal Phosphocholine by Bierer, Donald E, Dubenko, Larisa G, Litvak, Joane, Gerber, R. Eric, Chu, Judy, Thai, Dung L, Tempesta, Michael S, Truong, Thien V

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