Search Results - "Litts, Bridget"

Circulating dsDNA, endothelial injury, and complement activation in thrombotic microangiopathy and GVHD by Gloude, Nicholas J., Khandelwal, Pooja, Luebbering, Nathan, Lounder, Dana T., Jodele, Sonata, Alder, Matthew N., Lane, Adam, Wilkey, Alyss, Lake, Kelly E., Litts, Bridget, Davies, Stella M.

“…Transplant-associated thrombotic microangiopathy (TA-TMA) is a common and poorly recognized complication of hematopoietic stem cell transplantation (HSCT)…”
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A novel strategy for identifying early acute kidney injury in pediatric hematopoietic stem cell transplantation by Benoit, Stefanie W., Dixon, Bradley P., Goldstein, Stuart L., Bennett, Michael R., Lane, Adam, Lounder, Dana T., Rotz, Seth J., Gloude, Nicholas J., Lake, Kelly E., Litts, Bridget, Davies, Stella M.

“…Acute kidney injury (AKI) is a common complication in pediatric hematopoietic stem cell transplantation (HSCT). Serum creatinine is an imprecise biomarker of…”
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Transcriptome analysis in acute gastrointestinal graft- versus host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease by Khandelwal, Pooja, Lounder, Dana T, Bartlett, Allison, Haberman, Yael, Jegga, Anil G, Ghandikota, Sudhir, Koo, Jane, Luebbering, Nathan, Leino, Daniel, Abdullah, Sheyar, Loveless, Michaela, Minar, Phillip, Lake, Kelly, Litts, Bridget, Karns, Rebekah, Nelson, Adam S, Denson, Lee A, Davies, Stella M

“…We performed transcriptomic analyses on freshly frozen (n=21) and paraffin-embedded (n=35) gastrointestinal (GI) biopsies from children with and without acute…”
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Endothelial injury, F-actin and vitamin-D binding protein after hematopoietic stem cell transplant and association with clinical outcomes by Luebbering, Nathan, Abdullah, Sheyar, Lounder, Dana, Lane, Adam, Dole, Nikhil, Rubinstein, Jeremy, Hewison, Martin, Gloude, Nicholas, Jodele, Sonata, Perentesis, Kitty M R, Lake, Kelly, Litts, Bridget, Duell, Alexandra, Dandoy, Christopher E, Davies, Stella M

“…Endothelial injury after hematopoietic stem cell transplant is an important initiating factor for early transplant toxicities of thrombotic microangiopathy and…”
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Ablation of IFNγ in myeloid cells suppresses liver inflammation and fibrogenesis in mice with hepatic small heterodimer partner (SHP) deletion by Zhu, Lin, Litts, Bridget, Wang, Yu, Rein, Jeffrey A., Atzrodt, Cassandra L., Chinnarasu, Sivaprakasam, An, Julia, Thorson, Ariel S., Xu, Yaomin, Stafford, John M.

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common complication of obesity and, in severe cases, progresses to metabolic…”
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Expressing the Human Cholesteryl Ester Transfer Protein Minigene Improves Diet-Induced Fatty Liver and Insulin Resistance in Female Mice by Zhu, Lin, An, Julia, Chinnarasu, Sivaprakasam, Luu, Thao, Pettway, Yasminye D, Fahey, Kelly, Litts, Bridget, Kim, Hye-Young H, Flynn, Charles R, Linton, MacRae F, Stafford, John M

“…Mounting evidence has shown that CETP has important physiological roles in adapting to chronic nutrient excess, specifically, to protect against diet-induced…”
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Interleukin-22 levels are increased in gastrointestinal graft- versus -host disease in children by Lounder, Dana T, Khandelwal, Pooja, Gloude, Nicholas J, Dandoy, Christopher E, Jodele, Sonata, Medvedovic, Mario, Denson, Lee A, Lane, Adam, Lake, Kelly, Litts, Bridget, Wilkey, Alyss, Davies, Stella M

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A Pilot Study of Human Milk to Reduce Intestinal Inflammation After Bone Marrow Transplant by Khandelwal, Pooja, Andersen, Heidi, Romick-Rosendale, Lindsey, Taggart, Cynthia B, Watanabe, Miki, Lane, Adam, Dandoy, Christopher E, Lake, Kelly E, Litts, Bridget A, Morrow, Ardythe L, Lee, Martin L, Haslam, David B, Davies, Stella M

“…Human milk administration in the early peritransplant period would lower intestinal inflammation after bone marrow transplant (BMT). Children 0-5 years…”
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Hepatocyte Small Heterodimer Partner Mediates Sex-Specific Effects on Triglyceride Metabolism via Androgen Receptor in Male Mice by Palmisano, Brian T, Zhu, Lin, Litts, Bridget, Burman, Andreanna, Yu, Sophia, Neuman, Joshua C, Anozie, Uche, Luu, Thao N, Edington, Emery M, Stafford, John M

“…Mechanisms of sex differences in hypertriglyceridemia remain poorly understood. Small heterodimer partner (SHP) is a nuclear receptor that regulates bile acid,…”
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Antibiotic Exposure and Reduced Short Chain Fatty Acid Production after Hematopoietic Stem Cell Transplant by Romick-Rosendale, Lindsey E., Haslam, David B., Lane, Adam, Denson, Lee, Lake, Kelly, Wilkey, Alyss, Watanabe, Miki, Bauer, Stuart, Litts, Bridget, Luebbering, Nathan, Dandoy, Christopher E., Davies, Stella M.

“…•Progressive declines in fecal SCFAs in the first weeks after HSCT were observed.•A role for reduction of SCFAs in initiation of gut inflammation after HSCT…”
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Prospective two center study of CD38 bright CD8+ effector memory T-cells as a predictor of acute GVHD by Khandelwal, Pooja, Chaturvedi, Vijaya, Owsley, Erika, Efebera, Yvonne A., Choe, Hannah, Bostic, Matthew, Kumchala, Prashanti, Rajgolikar, Girish, Ranganathan, Parvathi, Garzon, Ramiro, Lake, Kelly, Litts, Bridget, Duell, Alexandra, Elder, Patrick, Davies, Stella M., Lane, Adam, Jordan, Michael B., Vasu, Sumithra, Devine, Steven, Marsh, Rebecca A.

“…•Peripheral blood CD38 bright CD8+TEM cell expansion did not predict acute GVHD.•Markers of T-cell activation were not different in patients with and without…”
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Abstract 13763: Reducing Cardiovascular Disease Risk by Estrogen Treatment After Surgical Menopause in Combination With the Suppression of Interferon Gamma Pathway in Ldlr Null Mice by Zhu, Lin, Litts, Bridget, An, Julia, Rein, Jeffrey, Chinnarasu, Sivaprakasam, Linton, Macrae F, Stafford, John M

“…Abstract only Atherosclerotic cardiovascular disease (ASCVD) risk is increased in women after menopause, which has not been shown to be reversed by…”
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592-P: Exercise Training and a Chow Diet Improve High-Fat Diet (HFD)–Induced Metabolic Disorders via Different Pathways in Female Mice by ZHU, LIN, AN, JULIA, LITTS, BRIDGET, ATZRODT, CASSANDRA L., STAFFORD, JOHN M.

“…Understanding the mechanism by which healthy diet or exercise training improves metabolic outcomes is crucial to developing therapeutic targets for…”
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463-P: Fuel Expenditure and Deposition in Tissues after Exercise or Low-Fat Diet in Obese Female and Male Mice by AN, JULIA, ZHU, LIN, YU, SOPHIA, EDINGTON, EMERY, LITTS, BRIDGET, STAFFORD, JOHN M.

“…We hypothesized that a healthy diet and exercise improve energy metabolism through different pathways in males and females. Understanding the mechanism for a…”
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The Natural History of BK Polyomavirus and the Host Immune Response After Stem Cell Transplantation by Laskin, Benjamin L, Denburg, Michelle R, Furth, Susan L, Moatz, Taylor, Altrich, Michelle, Kleiboeker, Steve, Lutzko, Carolyn, Zhu, Xiang, Blackard, Jason T, Jodele, Sonata, Lane, Adam, Wallace, Gregory, Dandoy, Christopher E, Lake, Kelly, Duell, Alexandra, Litts, Bridget, Seif, Alix E, Olson, Timothy, Bunin, Nancy, Davies, Stella M

“…Abstract Background BK polyomavirus (BKPyV) is associated with symptomatic hemorrhagic cystitis after hematopoietic cell transplantation (HCT). Little is known…”
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Kupffer's vesicle size threshold for robust left–right patterning of the zebrafish embryo by Gokey, Jason J., Ji, Yongchang, Tay, Hwee Goon, Litts, Bridget, Amack, Jeffrey D.

“…Background: Motile cilia in the “organ of asymmetry” create directional fluid flows that are vital for left–right (LR) asymmetric patterning of vertebrate…”
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α4β7 Integrin expression and blockade in pediatric and young adult gastrointestinal graft‐versus‐host disease by Ibrahimova, Azada, Davies, Stella M., Lane, Adam, Jordan, Michael B., Lake, Kelly, Litts, Bridget, Chaturvedi, Vijaya, Owsley, Erika, Myers, Kasiani C., Nelson, Adam S., Mehta, Parinda A., Marsh, Rebecca A., Khandelwal, Pooja

“…Background We hypothesized that α4β7 integrin expression on effector memory T cells (TEMs) would be elevated in pediatric hematopoietic stem cell transplant…”
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The Intestinal Virome in Children Following Allogeneic Hematopoietic Stem Cell Transplantation Reveals Adenoviral and Polyomaviral Predominance and Protective Role of Bacteriophages from Bloodstream Infections by Khandelwal, Pooja, Haslam, David, Lake, Kelly E, Laskin, Benjamin, Blackard, Jason T, Litts, Bridget, Milburn, Olivia, Duell, Alexandra, Lane, Adam, Davies, Stella M.

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Tryptophan metabolism is dysregulated in individuals with Fanconi anemia by Bartlett, Allison L., Romick-Rosendale, Lindsey, Nelson, Adam, Abdullah, Sheyar, Luebbering, Nathan, Bartlett, Jamen, Brusadelli, Marion, Palumbo, Joseph S., Lake, Kelly, Litts, Bridget, Duell, Alexandra, Urbanski, Annette, Lane, Adam, Myers, Kasiani C., Wells, Susanne I., Davies, Stella M.

“…Fanconi anemia (FA) is a complex genetic disorder associated with progressive marrow failure and a strong predisposition to malignancy. FA is associated with…”
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Pediatric Acute Gvhd: Transcriptome Analysis of Gastrointestinal Biopsies Reveal a Unique Signature in Pediatric Acute GI Gvhd with Involvement of the ERK Pathway and Similarities with Pediatric Inflammatory Bowel Disease by Khandelwal, Pooja, Lounder, Dana T., Bartlett, Allison L., Luebbering, Nathan, Lake, Kelly E., Litts, Bridget, Duell, Alexandra, Karns, Rebekah, Denson, Lee A., Davies, Stella M.

“…Studies of target organs at the time of acute graft versus host disease (GVHD) are needed to identify novel inflammatory and regulatory pathways. We performed…”
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