Search Results - "Litton, Mark"

Tumor therapy with an antibody-targeted superantigen generates a dichotomy between local and systemic immune responses by Litton, MJ, Dohlsten, M, Hansson, J, Rosendahl, A, Ohlsson, L, Kalland, T, Andersson, J, Andersson, U

“…Repeated injections of a fusion protein containing the superantigen staphylococcal enterotoxin A (SEA) combined with a Fab fragment of a tumor-specific…”
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Genetically Engineered Superantigens as Tolerable Antitumor Agents by Hansson, Johan, Ohlsson, Lennart, Persson, Robert, Andersson, Gunnar, Ilback, Nils-Gunnar, Litton, Mark J., Kalland, Terje, Dohlsten, Mikael

“…Superantigens (SAg) are a family of bacterial and viral proteins with strong immunostimulatory properties. SAg bound to major histocompatibility complex (MHC)…”
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Making the leap into entrepreneurship: job security in big pharma is not what it once was. For those looking for a new challenge, a group of big company refugees recount their experience starting up a new life science venture by Schatzman, Randall, Litton, Mark, Latham, John, Smith, Jeffrey

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Making the leap into entrepreneurship by Schatzman, Randall, Litton, Mark, Latham, John, Smith, Jeffrey

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Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells by Macatonia, SE, Hosken, NA, Litton, M, Vieira, P, Hsieh, CS, Culpepper, JA, Wysocka, M, Trinchieri, G, Murphy, KM, O'Garra, A

“…Dendritic cells are APCs that are unique in their potency to stimulate proliferation of primary Ag-specific responses in vitro and in vivo. In this study, we…”
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Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10 by Roth, I, Corry, D B, Locksley, R M, Abrams, J S, Litton, M J, Fisher, S J

“…The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination…”
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Antibody-Targeted Superantigens are Potent Inducers of Tumor-Infiltrating T Lymphocytes in vivo by Dohlsten, Mikael, Hansson, Johan, Ohlsson, Lennart, Litton, Mark, Kalland, Terje

“…Recruitment of antigen-specific tumorinfiltrating lymphocytes (TILs) is a major goal for immunotherapy of malignant tumors. We now describe that…”
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Antibody-targeted superantigen therapy induces tumor-infiltrating lymphocytes, excessive cytokine production, and apoptosis in human colon carcinoma by Litton, M J, Dohlsten, M, Lando, P A, Kalland, T, Ohlsson, L, Andersson, J, Andersson, U

“…Bacterial superantigens are the most potent known activators of human T lymphocytes. To engineer superantigens for immunotherapy of human colon carcinoma, the…”
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Correction: Antibody-Targeted Superantigens are Potent Inducers of Tumor- Infiltrating T Lymphocytes in vivo by Mikael Dohlsten, Johan Hansson, Lennart Ohlsson, Mark Litton, Terje Kalland

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Early expression of cytokines in lymph nodes after treatment in vivo with Staphylococcus enterotoxin B by Litton, M J, Sander, B, Murphy, E, O'Garra, A, Abrams, J S

“…Excessive cytokine expression induced by superantigen may be one aspect of the pathophysiology associated with Gram positive bacteremia. We have undertaken a…”
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The production of immunoregulatory cytokines is localized to the extrafollicular area of human tonsils by Agren, K, Andersson, U, Litton, M, Funa, K, Nordlander, B, Andersson, J

“…The localization and production at the single cell level of 19 different human cytokines, IL-1 alpha, IL-1 beta, IL-1ra, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8,…”
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Antibody-targeted superantigens in cancer immunotherapy by Søgaard, Morten, Hansson, Johan, Litton, Mark J., Ohlsson, Lennart, Rosendahl, Alexander, Lando, Peter A., Antonsson, Per, Kalland, Terje, Dohlsten, Mikael

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