Search Results - "Littlejohn, Mathew"

Modulation of the maternal immune system by the pre-implantation embryo by Walker, Caroline G, Meier, Susanne, Littlejohn, Mathew D, Lehnert, Klaus, Roche, John R, Mitchell, Murray D

“…A large proportion of pregnancy losses occur during the pre-implantation period, when the developing embryo is elongating rapidly and signalling its presence…”
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Genetic variation in histone modifications and gene expression identifies regulatory variants in the mammary gland of cattle by Prowse-Wilkins, Claire P, Lopdell, Thomas J, Xiang, Ruidong, Vander Jagt, Christy J, Littlejohn, Mathew D, Chamberlain, Amanda J, Goddard, Michael E

“…Causal variants for complex traits, such as eQTL are often found in non-coding regions of the genome, where they are hypothesised to influence phenotypes by…”
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A frameshift-deletion mutation in Reelin causes cerebellar hypoplasia in White Swiss Shepherd dogs by Littlejohn, Mathew D, Sneddon, Nick, Dittmer, Keren, Keehan, Mike, Stephen, Melissa, Drögemüller, Michaela, Garrick, Dorian

“…Cerebellar hypoplasia is a heterogeneous neurological condition in which the cerebellum is smaller than usual or not completely developed. The condition can…”
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Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature by Karim, Latifa, Takeda, Haruko, Lin, Li, Druet, Tom, Arias, Juan A C, Baurain, Denis, Cambisano, Nadine, Davis, Stephen R, Farnir, Frédéric, Grisart, Bernard, Harris, Bevin L, Keehan, Mike D, Littlejohn, Mathew D, Spelman, Richard J, Georges, Michel, Coppieters, Wouter

“…Michel Georges and colleagues report fine mapping and functional characterization of a quantitative trait locus with a large effect on bovine stature. They…”
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Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle by Littlejohn, Mathew D., Henty, Kristen M., Tiplady, Kathryn, Johnson, Thomas, Harland, Chad, Lopdell, Thomas, Sherlock, Richard G., Li, Wanbo, Lukefahr, Steven D., Shanks, Bruce C., Garrick, Dorian J., Snell, Russell G., Spelman, Richard J., Davis, Stephen R.

“…Lactation, hair development and homeothermy are characteristic evolutionary features that define mammals from other vertebrate species. Here we describe the…”
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Sequence-based Association Analysis Reveals an MGST1 eQTL with Pleiotropic Effects on Bovine Milk Composition by Littlejohn, Mathew D., Tiplady, Kathryn, Fink, Tania A., Lehnert, Klaus, Lopdell, Thomas, Johnson, Thomas, Couldrey, Christine, Keehan, Mike, Sherlock, Richard G., Harland, Chad, Scott, Andrew, Snell, Russell G., Davis, Stephen R., Spelman, Richard J.

“…The mammary gland is a prolific lipogenic organ, synthesising copious amounts of triglycerides for secretion into milk. The fat content of milk varies widely…”
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A new mechanism for a familiar mutation - bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement by Fink, Tania, Lopdell, Thomas J, Tiplady, Kathryn, Handley, Renee, Johnson, Thomas J J, Spelman, Richard J, Davis, Stephen R, Snell, Russell G, Littlejohn, Mathew D

“…The DGAT1 gene encodes an enzyme responsible for catalysing the terminal reaction in mammary triglyceride synthesis, and underpins a well-known pleiotropic…”
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Allele-specific binding variants causing ChIP-seq peak height of histone modification are not enriched in expression QTL annotations by Ghoreishifar, Mohammad, Chamberlain, Amanda J, Xiang, Ruidong, Prowse-Wilkins, Claire P, Lopdell, Thomas J, Littlejohn, Mathew D, Pryce, Jennie E, Goddard, Michael E

“…Genome sequence variants affecting complex traits (quantitative trait loci, QTL) are enriched in functional regions of the genome, such as those marked by…”
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Comparison of the genetic characteristics of directly measured and Fourier-transform mid-infrared-predicted bovine milk fatty acids and proteins by Tiplady, Kathryn M., Lopdell, Thomas J., Sherlock, Richard G., Johnson, Thomas J.J., Spelman, Richard J., Harris, Bevin L., Davis, Stephen R., Littlejohn, Mathew D., Garrick, Dorian J.

“…Fourier-transform mid-infrared (FT-MIR) spectroscopy is a high-throughput and inexpensive methodology used to evaluate concentrations of fat and protein in…”
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Non-additive association analysis using proxy phenotypes identifies novel cattle syndromes by Reynolds, Edwardo G. M., Neeley, Catherine, Lopdell, Thomas J., Keehan, Michael, Dittmer, Keren, Harland, Chad S., Couldrey, Christine, Johnson, Thomas J. J., Tiplady, Kathryn, Worth, Gemma, Walker, Mark, Davis, Stephen R., Sherlock, Richard G., Carnie, Katie, Harris, Bevin L., Charlier, Carole, Georges, Michel, Spelman, Richard J., Garrick, Dorian J., Littlejohn, Mathew D.

“…Mammalian species carry ~100 loss-of-function variants per individual 1 , 2 , where ~1–5 of these impact essential genes and cause embryonic lethality or…”
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Pathology of the peripheral neuropathy Charcot-Marie-Tooth disease type 4H in Holstein Friesian cattle with a splice site mutation in FGD4 by Dittmer, Keren E., Neeley, Catherine, Perrott, Matthew R., Reynolds, Edwardo, Garrick, Dorian J., Littlejohn, Mathew D.

“…Charcot-Marie-Tooth disease (CMT) is a hereditary sensory and motor peripheral neuropathy that is one of the most common inherited neurological diseases of…”
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DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content by Lopdell, Thomas J, Tiplady, Kathryn, Struchalin, Maksim, Johnson, Thomas J J, Keehan, Michael, Sherlock, Ric, Couldrey, Christine, Davis, Stephen R, Snell, Russell G, Spelman, Richard J, Littlejohn, Mathew D

“…Lactose provides an easily-digested energy source for neonates, and is the primary carbohydrate in milk in most species. Bovine lactose is also a key component…”
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NGS-based reverse genetic screen for common embryonic lethal mutations compromising fertility in livestock by Charlier, Carole, Li, Wanbo, Harland, Chad, Littlejohn, Mathew, Coppieters, Wouter, Creagh, Frances, Davis, Steve, Druet, Tom, Faux, Pierre, Guillaume, François, Karim, Latifa, Keehan, Mike, Kadri, Naveen Kumar, Tamma, Nico, Spelman, Richard, Georges, Michel

“…We herein report the result of a large-scale, next generation sequencing (NGS)-based screen for embryonic lethal (EL) mutations in Belgian beef and New Zealand…”
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The genomes of precision edited cloned calves show no evidence for off-target events or increased de novo mutagenesis by Jivanji, Swati, Harland, Chad, Cole, Sally, Brophy, Brigid, Garrick, Dorian, Snell, Russell, Littlejohn, Mathew, Laible, Götz

“…Animal health and welfare are at the forefront of public concern and the agricultural sector is responding by prioritising the selection of welfare-relevant…”
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Functional confirmation of PLAG1 as the candidate causative gene underlying major pleiotropic effects on body weight and milk characteristics by Fink, Tania, Tiplady, Kathryn, Lopdell, Thomas, Johnson, Thomas, Snell, Russell G., Spelman, Richard J., Davis, Stephen R., Littlejohn, Mathew D.

“…A major pleiotropic quantitative trait locus (QTL) located at ~25 Mbp on bovine chromosome 14 affects a myriad of growth and developmental traits in Bos taurus…”
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Sequence-based genome-wide association study of individual milk mid-infrared wavenumbers in mixed-breed dairy cattle by Tiplady, Kathryn M, Lopdell, Thomas J, Reynolds, Edwardo, Sherlock, Richard G, Keehan, Michael, Johnson, Thomas Jj, Pryce, Jennie E, Davis, Stephen R, Spelman, Richard J, Harris, Bevin L, Garrick, Dorian J, Littlejohn, Mathew D

“…Fourier-transform mid-infrared (FT-MIR) spectroscopy provides a high-throughput and inexpensive method for predicting milk composition and other novel traits…”
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A common regulatory haplotype doubles lactoferrin concentration in milk by Lopdell, Thomas J, Trevarton, Alexander J, Moody, Janelle, Prowse-Wilkins, Claire, Knowles, Sarah, Tiplady, Kathryn, Chamberlain, Amanda J, Goddard, Michael E, Spelman, Richard J, Lehnert, Klaus, Snell, Russell G, Davis, Stephen R, Littlejohn, Mathew D

“…Bovine lactoferrin (Lf) is an iron absorbing whey protein with antibacterial, antiviral, and antifungal activity. Lactoferrin is economically valuable and has…”
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Genome-wide association analysis reveals QTL and candidate mutations involved in white spotting in cattle by Jivanji, Swati, Worth, Gemma, Lopdell, Thomas J, Yeates, Anna, Couldrey, Christine, Reynolds, Edwardo, Tiplady, Kathryn, McNaughton, Lorna, Johnson, Thomas J J, Davis, Stephen R, Harris, Bevin, Spelman, Richard, Snell, Russell G, Garrick, Dorian, Littlejohn, Mathew D

“…White spotting of the coat is a characteristic trait of various domestic species including cattle and other mammals. It is a hallmark of Holstein-Friesian…”
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Expression variants of the lipogenic AGPAT6 gene affect diverse milk composition phenotypes in Bos taurus by Littlejohn, Mathew D, Tiplady, Kathryn, Lopdell, Thomas, Law, Tania A, Scott, Andrew, Harland, Chad, Sherlock, Ric, Henty, Kristen, Obolonkin, Vlad, Lehnert, Klaus, Macgibbon, Alistair, Spelman, Richard J, Davis, Stephen R, Snell, Russell G

“…Milk is composed of a complex mixture of lipids, proteins, carbohydrates and various vitamins and minerals as a source of nutrition for young mammals. The…”
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Screening for phenotypic outliers identifies an unusually low concentration of a β-lactoglobulin B protein isoform in bovine milk caused by a synonymous SNP by Davis, Stephen R, Ward, Hamish E, Kelly, Van, Palmer, David, Ankersmit-Udy, Alexandra E, Lopdell, Thomas J, Berry, Sarah D, Littlejohn, Mathew D, Tiplady, Kathryn, Adams, Linda F, Carnie, Katie, Burrett, Alayna, Thomas, Natalie, Snell, Russell G, Spelman, Richard J, Lehnert, Klaus

“…Milk samples from 10,641 dairy cattle were screened by a mass spectrometry method for extreme concentrations of the A or B isoforms of the whey protein,…”
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