Search Results - "Little, Sean C."

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall by Liu, Xiaoping, El-Mahdy, Mohamed A., Boslett, James, Varadharaj, Saradhadevi, Hemann, Craig, Abdelghany, Tamer M., Ismail, Raed S., Little, Sean C., Zhou, Danlei, Thuy, Le Thi Thanh, Kawada, Norifumi, Zweier, Jay L.

“…The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regulator of O 2 -dependent NO degradation in smooth muscle remains…”
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NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model by Peterson, Jennifer M., Wang, David J., Shettigar, Vikram, Roof, Steve R., Canan, Benjamin D., Bakkar, Nadine, Shintaku, Jonathan, Gu, Jin-Mo, Little, Sean C., Ratnam, Nivedita M., Londhe, Priya, Lu, Leina, Gaw, Christopher E., Petrosino, Jennifer M., Liyanarachchi, Sandya, Wang, Huating, Janssen, Paul M. L., Davis, Jonathan P., Ziolo, Mark T., Sharma, Sudarshana M., Guttridge, Denis C.

“…Duchenne muscular dystrophy (DMD) is a neuromuscular disorder causing progressive muscle degeneration. Although cardiomyopathy is a leading mortality cause in…”
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Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart by DeGrande, Sean T., Little, Sean C., Nixon, Derek J., Wright, Patrick, Snyder, Jedidiah, Dun, Wen, Murphy, Nathaniel, Kilic, Ahmet, Higgins, Robert, Binkley, Philip F., Boyden, Penelope A., Carnes, Cynthia A., Anderson, Mark E., Hund, Thomas J., Mohler, Peter J.

“…Kinase/phosphatase balance governs cardiac excitability in health and disease. Although detailed mechanisms for cardiac kinase regulation are established, far…”
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Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease by Shettigar, Vikram, Zhang, Bo, Little, Sean C., Salhi, Hussam E., Hansen, Brian J., Li, Ning, Zhang, Jianchao, Roof, Steve R., Ho, Hsiang-Ting, Brunello, Lucia, Lerch, Jessica K., Weisleder, Noah, Fedorov, Vadim V., Accornero, Federica, Rafael-Fortney, Jill A., Gyorke, Sandor, Janssen, Paul M. L., Biesiadecki, Brandon J., Ziolo, Mark T., Davis, Jonathan P.

“…Treatment for heart disease, the leading cause of death in the world, has progressed little for several decades. Here we develop a protein engineering approach…”
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Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in Duchenne muscular dystrophy patients and in dystrophin deficient rodents by Robertson, Alan S, Majchrzak, Mark J, Smith, Courtney M, Gagnon, Robert C, Devidze, Nino, Banks, Glen B, Little, Sean C, Nabbie, Fizal, Bounous, Denise I, DiPiero, Janet, Jacobsen, Leslie K, Bristow, Linda J, Ahlijanian, Michael K, Stimpson, Stephen A

“…Highlights • New immunoassays were developed for quantification of amino-terminal fragments of titin in urine. • A 365-fold increase in urinary titin…”
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The Rates of Ca2+ Dissociation and Cross-bridge Detachment from Ventricular Myofibrils as Reported by a Fluorescent Cardiac Troponin C by Little, Sean C., Biesiadecki, Brandon J., Kilic, Ahmet, Higgins, Robert S.D., Janssen, Paul M.L., Davis, Jonathan P.

“…The rate-limiting step of cardiac muscle relaxation has been proposed to reside in the myofilament. Both the rates of cross-bridge detachment and Ca2+…”
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TRPM4 modulates sinus node diastolic depolarization by Little, Sean C., PhD, Mohler, Peter J., PhD

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Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides by Anderson, Brian R., Jensen, Marianne L., Hagedorn, Peter H., Little, Sean C., Olson, Richard E., Ammar, Ron, Kienzle, Bernadette, Thompson, John, McDonald, Ivar, Mercer, Stephen, Vikesaa, Jonas, Nordbo, Bettina, Iben, Larry, Cao, Yang, Natale, Joanne, Dalton-Kay, Greg, Cacace, Angela, Hansen, Bo R., Hedtjärn, Maj, Koch, Troels, Bristow, Linda J.

“…Hundreds of dominant-negative myosin mutations have been identified that lead to hypertrophic cardiomyopathy, and the biomechanical link between mutation and…”
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Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure by Makara, Michael A., PhD, Curran, Jerry, PhD, Lubbers, Ellen R., BS, Murphy, Nathaniel P., BS, Little, Sean C., PhD, Musa, Hassan, PhD, Smith, Sakima A., MD, Unudurthi, Sathya D., PhD, Rajaram, Murugesan V.S., PhD, Janssen, Paul M.L., PhD, Boyden, Penelope A., PhD, Bradley, Elisa A., MD, Hund, Thomas J., PhD, Mohler, Peter J., PhD

“…Visual Abstract…”
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Ankyrin-G Coordinates Intercalated Disc Signaling Platform to Regulate Cardiac Excitability In Vivo by Makara, Michael A, Curran, Jerry, Little, Sean C, Musa, Hassan, Polina, Iuliia, Smith, Sakima A, Wright, Patrick J, Unudurthi, Sathya D, Snyder, Jed, Bennett, Vann, Hund, Thomas J, Mohler, Peter J

“…RATIONALE:Nav1.5 (SCN5A) is the primary cardiac voltage-gated Nav channel. Nav1.5 is critical for cardiac excitability and conduction, and human SCN5A…”
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Measurement of calcium dissociation rates from troponin C in rigor skeletal myofibrils by Little, Sean C, Tikunova, Svetlana B, Norman, Catalina, Swartz, Darl R, Davis, Jonathan P

“…Ca2+ dissociation from the regulatory domain of troponin C may influence the rate of striated muscle relaxation. However, Ca(2+) dissociation from troponin C…”
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AMP-activated Protein Kinase Phosphorylates Cardiac Troponin I at Ser-150 to Increase Myofilament Calcium Sensitivity and Blunt PKA-dependent Function by Nixon, Benjamin R., Thawornkaiwong, Ariyoporn, Jin, Janel, Brundage, Elizabeth A., Little, Sean C., Davis, Jonathan P., Solaro, R. John, Biesiadecki, Brandon J.

“…AMP-activated protein kinase (AMPK) is an energy-sensing enzyme central to the regulation of metabolic homeostasis. In the heart AMPK is activated during…”
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Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia by Smith, Sakima A, Sturm, Amy C, Curran, Jerry, Kline, Crystal F, Little, Sean C, Bonilla, Ingrid M, Long, Victor P, Makara, Michael, Polina, Iuliia, Hughes, Langston D, Webb, Tyler R, Wei, Zhiyi, Wright, Patrick, Voigt, Niels, Bhakta, Deepak, Spoonamore, Katherine G, Zhang, Chuansheng, Weiss, Raul, Binkley, Philip F, Janssen, Paul M, Kilic, Ahmet, Higgins, Robert S, Sun, Mingzhai, Ma, Jianjie, Dobrev, Dobromir, Zhang, Mingjie, Carnes, Cynthia A, Vatta, Matteo, Rasband, Matthew N, Hund, Thomas J, Mohler, Peter J

“…The cardiac cytoskeleton plays key roles in maintaining myocyte structural integrity in health and disease. In fact, human mutations in cardiac cytoskeletal…”
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Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart by Little, Sean C, Curran, Jerry, Makara, Michael A, Kline, Crystal F, Ho, Hsiang-Ting, Xu, Zhaobin, Wu, Xiangqiong, Polina, Iuliia, Musa, Hassan, Meadows, Allison M, Carnes, Cynthia A, Biesiadecki, Brandon J, Davis, Jonathan P, Weisleder, Noah, Györke, Sandor, Wehrens, Xander H, Hund, Thomas J, Mohler, Peter J

“…Protein phosphatase 2A (PP2A) is a serine/threonine-selective holoenzyme composed of a catalytic, scaffolding, and regulatory subunit. In the heart, PP2A…”
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EHD3-Dependent Endosome Pathway Regulates Cardiac Membrane Excitability and Physiology by Curran, Jerry, Makara, Michael A, Little, Sean C, Musa, Hassan, Liu, Bin, Wu, Xiangqiong, Polina, Iuliia, Alecusan, Joseph S, Wright, Patrick, Li, Jingdong, Billman, George E, Boyden, Penelope A, Gyorke, Sandor, Band, Hamid, Hund, Thomas J, Mohler, Peter J

“…RATIONALE:Cardiac function is dependent on the coordinate activities of membrane ion channels, transporters, pumps, and hormone receptors to tune the membrane…”
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Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity and accelerates deactivation in an acidic environment by Nixon, Benjamin R, Walton, Shane D, Zhang, Bo, Brundage, Elizabeth A, Little, Sean C, Ziolo, Mark T, Davis, Jonathan P, Biesiadecki, Brandon J

“…The binding of Ca(2+) to troponin C (TnC) in the troponin complex is a critical step regulating the thin filament, the actin-myosin interaction and cardiac…”
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Designing proteins to combat disease: Cardiac troponin C as an example by Davis, Jonathan P., Shettigar, Vikram, Tikunova, Svetlana B., Little, Sean C., Liu, Bin, Siddiqui, Jalal K., Janssen, Paul M.L., Ziolo, Mark T., Walton, Shane D.

“…Throughout history, muscle research has led to numerous scientific breakthroughs that have brought insight to a more general understanding of all biological…”
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Obligatory role of neuronal nitric oxide synthase in the heart's antioxidant adaptation with exercise by Roof, Steve R, Ho, Hsiang-Ting, Little, Sean C, Ostler, Joseph E, Brundage, Elizabeth A, Periasamy, Muthu, Villamena, Frederick A, Györke, Sandor, Biesiadecki, Brandon J, Heymes, Christophe, Houser, Steven R, Davis, Jonathan P, Ziolo, Mark T

“…Abstract Excessive oxidative stress in the heart results in contractile dysfunction. While antioxidant therapies have been a disappointment clinically,…”
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Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria by Curran, Jerry, Musa, Hassan, Kline, Crystal F., Makara, Michael A., Little, Sean C., Higgins, John D., Hund, Thomas J., Band, Hamid, Mohler, Peter J.

“…Proper trafficking of membrane-bound ion channels and transporters is requisite for normal cardiac function. Endosome-based protein trafficking of…”
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Effect of Calcium-Sensitizing Mutations on Calcium Binding and Exchange with Troponin C in Increasingly Complex Biochemical Systems by Tikunova, Svetlana B, Liu, Bin, Swindle, Nicholas, Little, Sean C, Gomes, Aldrin V, Swartz, Darl R, Davis, Jonathan P

“…The calcium-dependent interactions between troponin C (TnC) and other thin and thick filament proteins play a key role in the regulation of cardiac muscle…”
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