Search Results - "Little, Mark"

Radiation and circulatory disease by Little, Mark P.

“…Exposure to therapeutic doses of ionizing radiation is associated with damage to the heart and coronary arteries. However, only recently have studies with…”
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Targeting of the cGAS-STING system by DNA viruses by Phelan, Thomas, Little, Mark A., Brady, Gareth

“…[Display omitted] Innate sensing of viruses by cytosolic nucleic acid sensors is a key feature of anti-viral immunity against these pathogens. The DNA sensing…”
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Commentary: Intra-arterial Injection of Temporary Embolic Material Through a Needle Inserted into the Radial or Ulnar Artery for Distal and Proximal Interphalangeal Joint Osteoarthritis: A Retrospective Study of 92 Patients by Little, Mark W.

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Potential Impacts of Leakage from Deep CO2 Geosequestration on Overlying Freshwater Aquifers by Little, Mark G, Jackson, Robert B

“…Carbon Capture and Storage may use deep saline aquifers for CO2 sequestration, but small CO2 leakage could pose a risk to overlying fresh groundwater. We…”
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EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update by Hellmich, Bernhard, Sanchez-Alamo, Beatriz, Schirmer, Jan H, Berti, Alvise, Blockmans, Daniel, Cid, Maria C, Holle, Julia U, Hollinger, Nicole, Karadag, Omer, Kronbichler, Andreas, Little, Mark A, Luqmani, Raashid A, Mahr, Alfred, Merkel, Peter A, Mohammad, Aladdin J, Monti, Sara, Mukhtyar, Chetan B, Musial, Jacek, Price-Kuehne, Fiona, Segelmark, Mårten, Teng, Y K Onno, Terrier, Benjamin, Tomasson, Gunnar, Vaglio, Augusto, Vassilopoulos, Dimitrios, Verhoeven, Peter, Jayne, David

“…Since the publication of the EULAR recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in 2016,…”
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Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study by Pearce, Mark S, Dr, Salotti, Jane A, PhD, Little, Mark P, PhD, McHugh, Kieran, FRCR, Lee, Choonsik, PhD, Kim, Kwang Pyo, PhD, Howe, Nicola L, MSc, Ronckers, Cecile M, PhD, Rajaraman, Preetha, PhD, Craft, Alan W, MD, Parker, Louise, PhD, Berrington de González, Amy, DPhil

“…Summary Background Although CT scans are very useful clinically, potential cancer risks exist from associated ionising radiation, in particular for children…”
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A review of non-cancer effects, especially circulatory and ocular diseases by Little, Mark P.

“…There is a well-established association between high doses (>5 Gy) of ionizing radiation exposure and damage to the heart and coronary arteries, although only…”
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Low-Dose Extrapolation Factors Implied by Mortality and Incidence Data from the Japanese Atomic Bomb Survivor Life Span Study Data by Little, Mark P., Hamada, Nobuyuki

“…Assessment of the effect of low dose and low-dose-rate exposure depends critically on extrapolation from groups exposed at high dose and high-dose rates such…”
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An update on effects of ionizing radiation exposure on the eye by Hamada, Nobuyuki, Azizova, Tamara V, Little, Mark P

“…The International Commission on Radiological Protection (ICRP) has considered for over 60 years that the lens of the eye is among the most radiosensitive…”
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Second Solid Cancers After Radiation Therapy: A Systematic Review of the Epidemiologic Studies of the Radiation Dose-Response Relationship by Berrington de Gonzalez, Amy, DPhil, Gilbert, Ethel, PhD, Curtis, Rochelle, MA, Inskip, Peter, ScD, Kleinerman, Ruth, MPH, Morton, Lindsay, PhD, Rajaraman, Preetha, PhD, Little, Mark P., DPhil

“…Rapid innovations in radiation therapy techniques have resulted in an urgent need for risk projection models for second cancer risks from high-dose radiation…”
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Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology by Little, Mark P., Azizova, Tamara V., Hamada, Nobuyuki

“…There are well-known correlations between high and moderate doses (>0.5 Gy) of ionizing radiation exposure and circulatory system damage, also between…”
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Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review by Scott, Jennifer, Hartnett, Jack, Mockler, David, Little, Mark A.

“…Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a rare multi-system autoimmune disease, characterised by a pauci-immune necrotising…”
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Ionizing radiation-induced circulatory and metabolic diseases by Tapio, Soile, Little, Mark P., Kaiser, Jan Christian, Impens, Nathalie, Hamada, Nobuyuki, Georgakilas, Alexandros G., Simar, David, Salomaa, Sisko

“…•Ionizing radiation causes adverse circulatory and metabolic effects at high doses.•Low-dose radiation is causally associated with circulatory disease.•Impact…”
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Cancer risks among studies of medical diagnostic radiation exposure in early life without quantitative estimates of dose by Little, Mark P., Wakeford, Richard, Bouffler, Simon D., Abalo, Kossi, Hauptmann, Michael, Hamada, Nobuyuki, Kendall, Gerald M.

“…There is accumulating evidence of excess risk of cancer in various populations exposed at acute doses below several tens of mSv or doses received over a…”
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Molluscum Contagiosum Virus Protein MC008 Targets NF-κB Activation by Inhibiting Ubiquitination of NEMO by Phelan, Thomas, Lawler, Clara, Pichlmair, Andreas, Little, Mark A, Bowie, Andrew G, Brady, Gareth

“…Molluscum contagiosum virus (MCV) is a human-adapted poxvirus that causes a common and persistent yet mild infection characterized by distinct, contagious,…”
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Pathogenesis of ANCA-associated vasculitis: an emerging role for immunometabolism by Leacy, Emma, Brady, Gareth, Little, Mark A

“…Abstract ANCA-associated vasculitis (AAV) is a severe systemic autoimmune disease. A key feature of AAV is the presence of Anti-Neutrophil Cytoplasmic…”
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Revisiting an Inverse Dose-Fractionation Effect of Ionizing Radiation Exposure for Ischemic Heart Disease: Insights from Recent Studies by Zablotska, Lydia B., Little, Mark P., Hamada, Nobuyuki

“…Over the last two decades, there has been emerging evidence suggesting that ionizing radiation exposures could be associated with elevated risks of…”
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Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system by Little, Mark A, Al-Ani, Bahjat, Ren, Shuyu, Al-Nuaimi, Hamad, Leite, Jr, Maurilo, Alpers, Charles E, Savage, Caroline O, Duffield, Jeremy S

“…Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with…”
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Relapse Prediction in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by Nic an Ríogh, Eithne, Little, Mark A.

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Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses by Little, Mark P., Wakeford, Richard, Bouffler, Simon D., Abalo, Kossi, Hauptmann, Michael, Hamada, Nobuyuki, Kendall, Gerald M.

“…•There is mounting evidence of cancer risk from low dose radiation in childhood.•A systematic review was conducted of cancer after exposure in utero or…”
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