Search Results - "Litterst, Claudia"

Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution by Ludlow, Andrew T, Robin, Jerome D, Sayed, Mohammed, Litterst, Claudia M, Shelton, Dawne N, Shay, Jerry W, Wright, Woodring E

“…The telomere repeat amplification protocol (TRAP) for the human reverse transcriptase, telomerase, is a PCR-based assay developed two decades ago and is still…”
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Multiplexed Target Detection Using DNA-Binding Dye Chemistry in Droplet Digital PCR by McDermott, Geoffrey P, Do, Duc, Litterst, Claudia M, Maar, Dianna, Hindson, Christopher M, Steenblock, Erin R, Legler, Tina C, Jouvenot, Yann, Marrs, Samuel H, Bemis, Adam, Shah, Pallavi, Wong, Josephine, Wang, Shenglong, Sally, David, Javier, Leanne, Dinio, Theresa, Han, Chunxiao, Brackbill, Timothy P, Hodges, Shawn P, Ling, Yunfeng, Klitgord, Niels, Carman, George J, Berman, Jennifer R, Koehler, Ryan T, Hiddessen, Amy L, Walse, Pramod, Bousse, Luc, Tzonev, Svilen, Hefner, Eli, Hindson, Benjamin J, Cauly, Thomas H, Hamby, Keith, Patel, Viresh P, Regan, John F, Wyatt, Paul W, Karlin-Neumann, George A, Stumbo, David P, Lowe, Adam J

“…Two years ago, we described the first droplet digital PCR (ddPCR) system aimed at empowering all researchers with a tool that removes the substantial…”
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Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets by Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.

“…A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human kinome was used to discover regulators of RNAi. Here we report that the…”
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Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling by Georgakopoulos, Anastasios, Litterst, Claudia, Ghersi, Enrico, Baki, Lia, Xu, ChiJie, Serban, Geo, Robakis, Nikolaos K

“…Bidirectional signaling triggered by interacting ephrinB receptors (EphB) and ephrinB ligands is crucial for development and function of the vascular and…”
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FAD mutants unable to increase neurotoxic Aβ 42 suggest that mutation effects on neurodegeneration may be independent of effects on Aβ by Shioi, Junichi, Georgakopoulos, Anastasios, Mehta, Pankaj, Kouchi, Zen, Litterst, Claudia M., Baki, Lia, Robakis, Nikolaos K.

“…Strong support for a primary causative role of the Aβ peptides in the development of Alzheimer’s disease (AD) neurodegeneration derives from reports that…”
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Interaction of STAT6 with its co-activator SRC-1/NCoA-1 is regulated by dephosphorylation of the latter via PP2A by Münz, Tobias, Litterst, Claudia M, Pfitzner, Edith

“…Regulation of gene expression represents a central issue in signal-regulated cellular responses. STAT6 is a critical mediator of IL-4 stimulated gene…”
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An LXXLL Motif in the Transactivation Domain of STAT6 Mediates Recruitment of NCoA-1/SRC-1 by Litterst, Claudia M., Pfitzner, Edith

“…Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4)-induced tyrosine…”
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NCoA-1/SRC-1 Is an Essential Coactivator of STAT5 That Binds to the FDL Motif in the α-Helical Region of the STAT5 Transactivation Domain by Litterst, Claudia M., Kliem, Stefanie, Marilley, Dominique, Pfitzner, Edith

“…Signal transducer and activator of transcription 5 (STAT5) is a transcription factor that activates prolactin (PRL)-dependent gene expression in the mammary…”
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Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain by Razeto, Adelia, Ramakrishnan, Venkatesh, Litterst, Claudia M, Giller, Karin, Griesinger, Christian, Carlomagno, Teresa, Lakomek, Nils, Heimburg, Thomas, Lodrini, Marco, Pfitzner, Edith, Becker, Stefan

“…Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4) by direct interaction with…”
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Cadherins Mediate Both the Association between PS1 and β-Catenin and the Effects of PS1 on β-Catenin Stability by Serban, Geo, Kouchi, Zen, Baki, Lia, Georgakopoulos, Anastasios, Litterst, Claudia M., Shioi, Junichi, Robakis, Nikolaos K.

“…Presenilin1 (PS1), a protein involved in cellular development, forms functional complexes with β-catenin, a regulator of Wnt signaling and cell-cell adhesion…”
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Transcriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1 by Litterst, Claudia M., Pfitzner, Edith

“…Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation…”
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Coactivators in Gene Regulation by STAT5 by Litterst, Claudia M., Kliem, Stefanie, Lodrini, Marco, Pfitzner, Edith

“…Signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of transcription factors that relay the effect of diverse cytokines,…”
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Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor by Litterst, Claudia, Georgakopoulos, Anastasios, Shioi, Junichi, Ghersi, Enrico, Wisniewski, Thomas, Wang, Rong, Ludwig, Andreas, Robakis, Nikolaos K.

“…Binding of EphB receptors to ephrinB ligands on the surface of adjacent cells initiates signaling cascades that regulate angiogenesis, axonal guidance, and…”
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Very Low Abundance Single-Cell Transcript Quantification with 5-Plex ddPCR TM Assays by Karlin-Neumann, George, Zhang, Bin, Litterst, Claudia

“…Gene expression studies have provided one of the most accessible windows for understanding the molecular basis of cell and tissue phenotypes and how these…”
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Peptide EphB2/CTF2 Generated by the γ-Secretase Processing of EphB2 Receptor Promotes Tyrosine Phosphorylation and Cell Surface Localization of N-Methyl-d-aspartate Receptors by Xu, Jindong, Litterst, Claudia, Georgakopoulos, Anastasios, Zaganas, Ioannis, Robakis, Nikolaos K.

“…Presenilin 1, a protein involved in the development of familial Alzheimer disease, is an important functional component of the γ-secretase complex that…”
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Abstract 2301: Cross validation of NGS methylated targets using droplet digital PCR (ddPCR) by Shelton, Dawne N., Litterst, Claudia, Regan, John F., Moinova, Helen R., Markowitz, Sanford D.

“…Abstract DNA methylation is one of the most studied epigenetic modifications. DNA methylation plays an important role in a number of physiological processes as…”
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MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa by Calenda, Giulia, Villegas, Guillermo, Barnable, Patrick, Litterst, Claudia, Levendosky, Keith, Gettie, Agegnehu, Cooney, Michael L, Blanchard, James, Fernández-Romero, José A, Zydowsky, Thomas M, Teleshova, Natalia

“…The Population Councilʼs microbicide gel MZC (also known as PC-1005) containing MIV-150 and zinc acetate dihydrate (ZA) in carrageenan (CG) has shown promise…”
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Abstract 5156: Multiplexed EGFR mutation detection with C797S and T790M allelic context using six-color digital PCR by Yang, Wei, Christensen, Mari, Chan, Jennifer K., Tsai, Julie, Patten, Nancy, Tran, Ha B., Hillman, Grant R., Tai, Yu Chuan, Bogard, Patrick, Litterst, Claudia M., Brophy, Victoria H., Newton, Nick, Nelson, Christopher D., Pattje, Wouter J.

“…Abstract Non-small cell lung cancer (NSCLC) patients harboring activating mutations in epidermal growth factor receptor (EGFR) are benefited from Tyrosine…”
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Akt-mediated phosphorylation of Argonaute 2 down-regulates cleavage and up-regulates translational repression of microRNA targets by Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.

“…A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human kinome was used to discover regulators of RNAi. Here we report that the…”
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Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro by Hecht, A, Litterst, C M, Huber, O, Kemler, R

“…beta-Catenin, a member of the family of Armadillo repeat proteins, plays a dual role in cadherin-mediated cell adhesion and in signaling by Wnt growth factors…”
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