Search Results - "Litterman, Adam J"

Compact CRISPR genetic screens enabled by improved guide RNA library cloning by Heo, Seok-Jin, Enriquez, Lauren D, Federman, Scot, Chang, Amy Y, Mace, Rachel, Shevade, Kaivalya, Nguyen, Phuong, Litterman, Adam J, Shafer, Shawn, Przybyla, Laralynne, Chow, Eric D

“…CRISPR genome editing approaches theoretically enable researchers to define the function of each human gene in specific cell types, but challenges remain to…”
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miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival by Gagnon, John D., Kageyama, Robin, Shehata, Hesham M., Fassett, Marlys S., Mar, Darryl J., Wigton, Eric J., Johansson, Kristina, Litterman, Adam J., Odorizzi, Pamela, Simeonov, Dimitre, Laidlaw, Brian J., Panduro, Marisella, Patel, Sana, Jeker, Lukas T., Feeney, Margaret E., McManus, Michael T., Marson, Alexander, Matloubian, Mehrdad, Sanjabi, Shomyseh, Ansel, K. Mark

“…Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells,…”
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RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery by Chatrikhi, Rakesh, Mallory, Michael J., Gazzara, Matthew R., Agosto, Laura M., Zhu, Wandi S., Litterman, Adam J., Ansel, K. Mark, Lynch, Kristen W.

“…The 3′ UTR (UTR) of human mRNAs plays a critical role in controlling protein expression and function. Importantly, 3′ UTRs of human messages are not invariant…”
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GCLiPP: global crosslinking and protein purification method for constructing high-resolution occupancy maps for RNA binding proteins by Zhu, Wandi S, Litterman, Adam J, Sekhon, Harshaan S, Kageyama, Robin, Arce, Maya M, Taylor, Kimberly E, Zhao, Wenxue, Criswell, Lindsey A, Zaitlen, Noah, Erle, David J, Ansel, K Mark

“…GCLiPP is a global RNA interactome capture method that detects RNA-binding protein (RBP) occupancy transcriptome-wide. GCLiPP maps RBP-occupied sites at a…”
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Profound impairment of adaptive immune responses by alkylating chemotherapy by Litterman, Adam J, Zellmer, David M, Grinnen, Karen L, Hunt, Matthew A, Dudek, Arkadiusz Z, Salazar, Andres M, Ohlfest, John R

“…Overall, cancer vaccines have had a record of failure as an adjuvant therapy for malignancies that are treated with alkylating chemotherapy, and the…”
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Effective Treatment of Established GL261 Murine Gliomas through Picornavirus Vaccination-Enhanced Tumor Antigen-Specific CD8+ T Cell Responses by Renner, Danielle N, Jin, Fang, Litterman, Adam J, Balgeman, Alexis J, Hanson, Lisa M, Gamez, Jeffrey D, Chae, Michael, Carlson, Brett L, Sarkaria, Jann N, Parney, Ian F, Ohlfest, John R, Pirko, Istvan, Pavelko, Kevin D, Johnson, Aaron J

“…Glioblastoma (GBM) is among the most invasive and lethal of cancers, frequently infiltrating surrounding healthy tissue and giving rise to rapid recurrence. It…”
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Non-viral precision T cell receptor replacement for personalized cell therapy by Foy, Susan P., Jacoby, Kyle, Bota, Daniela A., Hunter, Theresa, Pan, Zheng, Stawiski, Eric, Ma, Yan, Lu, William, Peng, Songming, Wang, Clifford L., Yuen, Benjamin, Dalmas, Olivier, Heeringa, Katharine, Sennino, Barbara, Conroy, Andy, Bethune, Michael T., Mende, Ines, White, William, Kukreja, Monica, Gunturu, Swetha, Humphrey, Emily, Hussaini, Adeel, An, Duo, Litterman, Adam J., Quach, Boi Bryant, Ng, Alphonsus H. C., Lu, Yue, Smith, Chad, Campbell, Katie M., Anaya, Daniel, Skrdlant, Lindsey, Huang, Eva Yi-Hsuan, Mendoza, Ventura, Mathur, Jyoti, Dengler, Luke, Purandare, Bhamini, Moot, Robert, Yi, Michael C., Funke, Roel, Sibley, Alison, Stallings-Schmitt, Todd, Oh, David Y., Chmielowski, Bartosz, Abedi, Mehrdad, Yuan, Yuan, Sosman, Jeffrey A., Lee, Sylvia M., Schoenfeld, Adam J., Baltimore, David, Heath, James R., Franzusoff, Alex, Ribas, Antoni, Rao, Arati V., Mandl, Stefanie J.

“…T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells 1 – 3 . Here we developed a clinical-grade approach based on…”
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A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization by Litterman, Adam J, Kageyama, Robin, Le Tonqueze, Olivier, Zhao, Wenxue, Gagnon, John D, Goodarzi, Hani, Erle, David J, Ansel, K Mark

“…Compared to coding sequences, untranslated regions of the transcriptome are not well conserved, and functional annotation of these sequences is challenging…”
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Vaccine injection site matters: qualitative and quantitative defects in CD8 T cells primed as a function of proximity to the tumor in a murine glioma model by Ohlfest, John R, Andersen, Brian M, Litterman, Adam J, Xia, Junzhe, Pennell, Christopher A, Swier, Lauryn E, Salazar, Andres M, Olin, Michael R

“…Malignant gliomas are lethal brain tumors for which novel therapies are urgently needed. In animal models, vaccination with tumor-associated Ags efficiently…”
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Minicircle DNA is Superior to Plasmid DNA in Eliciting Antigen-specific CD8+ T-cell Responses by Dietz, Wynette M, Skinner, Nicole E B, Hamilton, Sara E, Jund, Michelle D, Heitfeld, Suzanne M, Litterman, Adam J, Hwu, Patrick, Chen, Zhi-Ying, Salazar, Andres M, Ohlfest, John R, Blazar, Bruce R, Pennell, Christopher A, Osborn, Mark J

“…Clinical trials reveal that plasmid DNA (pDNA)–based gene delivery must be improved to realize its potential to treat human disease. Current pDNA platforms…”
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Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination by Litterman, Adam J, Dudek, Arkadiusz Z, Largaespada, David A

“…Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating…”
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Oxygen Is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells by OLIN, Michael R, ANDERSON, Brian M, BLAZAR, Bruce R, OHLFEST, John R, LITTERMAN, Adam J, GROGAN, Patrick T, SARVER, Aaron L, ROBERTSON, Paul T, XUEQING LIANG, WEI CHEN, PARNEY, Ian F, HUNT, Matthew A

“…With recent approval of the first dendritic cell (DC) vaccine for patient use, many other DC vaccine approaches are now being tested in clinical trials. Many…”
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Antigen-specific culture of memory-like CD8 T cells for adoptive immunotherapy by Litterman, Adam J, Zellmer, David M, LaRue, Rebecca S, Jameson, Stephen C, Largaespada, David A

“…Cytotoxic T cells typically are expanded ex vivo in culture with IL2 for adoptive immunotherapy. This culture period leads to a differentiated phenotype and…”
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Abstract 4783: Highly efficient, non-viral precision genome engineering for the generation of personalized neoepitope-specific adoptive T cell therapies by Jacoby, Kyle, Moot, Robert, Lu, William, Nguyen, Diana, Sennino, Barbara, Conroy, Andrew, Purandare, Bhamini, Litterman, Adam J., Urbinati, Fabrizia, Foy, Susan P., Hunter, Theresa, Tai, Albert, Bethune, Michael T., Peng, Songming, Dalmas, Olivier, Franzusoff, Alex, Mandl, Stefanie J.

“…Abstract Methods used to engineer cells for adoptive cell therapies (ACT) utilizing receptors that are constant across many patients (CAR or shared Ag TCRs)…”
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169 : Direct in vitro generation of antigen specific, memory phenotype, Cd8+ T cells using a cocktail of small molecules and gamma-chain cytokines by Litterman, Adam J., Zellmer, David M., Largaespada, David A.

“…Adoptive T cell transfer is an emerging cancer immunotherapy that has yielded complete responses in solid tumors such as B cell lymphoma and melanoma that are…”
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169 by Litterman, Adam J., Zellmer, David M., Largaespada, David A.

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Abstract 2830: Multiplexed shRNAs targeting FAS and PTPN2 enhance CAR T persistence and anti-tumor efficacy by Gagnon, John, Litterman, Adam J., Hall, Jason A., Polyak, Dina, Zhou, Stanley, Joshi, Sahil, Takacsi-Nagy, Oliver, Pope, Hans, silva, luisa, Singh, brenal K., Granja, jeffrey M., DeTomaso, david, Aristil-Lepe, Edgar, Tan, Michelle, Galvin, Brendan, Zheng, Grace X., Santoro, Stephen, Cooper, Aaron, Bezman, Natalie, Haining, W Nicholas

“…Abstract Cell therapies have shown limited efficacy in solid tumors, in part due to limitations in CAR T cell survival, expansion, and resistance to…”
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Abstract B23: DNA damage response in responder lymphocytes reduces vaccine efficacy following alkylating chemotherapy by Litterman, Adam J., Zellmer, David M., Grinnen, Karen L., Dudek, Arkadiusz Z., Largaespada, David A., Ohlfest, John R.

“…Abstract The effect of alkylating chemotherapy on cancer vaccines is controversial, with numerous reports of immune stimulation via Treg depletion following…”
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Minicircle DNA is Superior to Plasmid DNA in Eliciting Antigen-specific CD8 super(+) T-cell Responses by Dietz, Wynette M, Skinner, Nicole E B, Hamilton, Sara E, Jund, Michelle D, Heitfeld, Bruce M, Litterman, Adam J, Hwu, Patrick, Chen, Zhi-Ying, Salazar, Andres M, Ohlfest, John R, Blazar, Bruce R, Pennell, Christopher A, Osborn, Mark J

“…Clinical trials reveal that plasmid DNA (pDNA)-based gene delivery must be improved to realize its potential to treat human disease. Current pDNA platforms…”
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Effective Treatment of Established GL261 Murine Gliomas through Picornavirus Vaccination-Enhanced Tumor Antigen-Specific CD8+ T Cell Responses: e0125565 by Renner, Danielle N, Jin, Fang, Litterman, Adam J, Balgeman, Alexis J, Hanson, Lisa M, Gamez, Jeffrey D, Chae, Michael, Carlson, Brett L, Sarkaria, Jann N, Parney, Ian F

“…Glioblastoma (GBM) is among the most invasive and lethal of cancers, frequently infiltrating surrounding healthy tissue and giving rise to rapid recurrence. It…”
Get full text