Bone regeneration with glass ceramic implants and calcium phosphate cements in a rabbit cranial defect model

Hydroxyapatite cement (BoneSource®) and brushite calcium phosphate cement (chronOS™ Inject) were tested for fixation of glass ceramic implants (Bioverit®) in experimentally created cranial defects in 24 adult New Zealand White rabbits. Aim of the in vivo study was to assess and compare the biocompat...

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Bibliographic Details
Published in:	Journal of materials science. Materials in medicine Vol. 21; no. 10; pp. 2853 - 2859
Main Authors:	Schneider, Gerlind, Blechschmidt, Karin, Linde, Dirk, Litschko, Peter, Körbs, Thomas, Beleites, Eggert
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-10-2010 Springer Springer Nature B.V
Subjects:	Adhesives Animals Biocompatible Materials Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bone Cements - chemistry Bone Regeneration Bone Substitutes - chemistry Calcium Phosphates - chemistry Ceramics Ceramics - chemistry Chemistry and Materials Science Composites Female Glass Glass - chemistry Hydroxyapatites Materials Science Materials Testing Medical sciences Models, Animal Natural Materials Orthopedic surgery Osseointegration Polymer Sciences Rabbits Regenerative Medicine/Tissue Engineering Skull - surgery Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thin Films Cement Material Calvarial Defect Cement Matrix Bone Cement Calcium Phosphate Cement Vertebrata Mammalia Implant Bone regeneration Diseases of the osteoarticular system Rabbit Calcium phosphate Biomaterial Bone defect Lagomorpha Glass ceramics Biomedical engineering
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Summary:	Hydroxyapatite cement (BoneSource®) and brushite calcium phosphate cement (chronOS™ Inject) were tested for fixation of glass ceramic implants (Bioverit®) in experimentally created cranial defects in 24 adult New Zealand White rabbits. Aim of the in vivo study was to assess and compare the biocompatibility and osseointegration of the implanted materials. Macroscopic and histological evaluations were performed 1 month, 3 months, and 6 months postoperatively. All implanted materials were well tolerated by the surrounding tissue. Both bone cements exhibited osteoconductive properties. Differences could be detected regarding to the rates of cement resorption and new bone formation. The brushite cement was resorbed faster than the hydroxyapatite cement. The chronOS™ Inject samples exhibited a higher rate of connective tissue formation and an insufficient osseointegration. BoneSource® was replaced by bone with minimal invasion of connective tissue. New bone formation occurred faster compared to the chronOS™ Inject group. Bioverit® implants fixed with BoneSource® were successfully osseointegrated.
ISSN:	0957-4530 1573-4838
DOI:	10.1007/s10856-010-4143-0