Search Results - "Lithgow, G J"

Drugs that target aging: how do we discover them? by Myers, A, Lithgow, G J

“…Biology of aging is focused on elucidating the biochemical and genetic pathways that contribute to cellular damage accumulation over time. Thirty years of…”
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Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics by Melov, Simon, Ravenscroft, Joanne, Malik, Sarwatt, Gill, Matt S., Walker, David W., Clayton, Peter E., Wallace, Douglas C., Malfroy, Bernard, Doctrow, Susan R., Lithgow, Gordon J.

“…We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic…”
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Thermotolerance and Extended Life-Span Conferred by Single-Gene Mutations and Induced by Thermal Stress by Lithgow, Gordon J., White, Tiffany M., Melov, Simon, Johnson, Thomas E.

“…We have discovered that three longevity mutants of the nematode Caenorhabditis elegans also exhibit increased intrinsic thermotolerance (Itt) as young adults…”
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Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans by Walker, G A, White, T M, McColl, G, Jenkins, N L, Babich, S, Candido, E P, Johnson, T E, Lithgow, G J

“…We present evidence for elevated levels of heat shock protein 16 (HSP16) in an intrinsically thermotolerant, long-lived strain of Caenorhabditis elegans during…”
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Mechanisms and Evolution of Aging by Lithgow, Gordon J., Thomas B. L. Kirkwood

“…In their Perspective, Lithgow and Kirkwood postulate that evolutionary theory predicts that the process of aging is not subject to selection in the same way as…”
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Oxidative stress and aging--the use of superoxide dismutase/catalase mimetics to extend lifespan by Sampayo, J N, Gill, M S, Lithgow, G J

“…To date, more than 40 genes have been identified in the nematode Caenorhabditis elegans, which, when mutated, lead to an increase in lifespan. Of those tested,…”
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Hypothesis: Interventions That Increase the Response to Stress Offer the Potential for Effective Life Prolongation and Increased Health by Johnson, Thomas E., Lithgow, Gordon J., Murakami, Shin

“…In the last decade it has become evident that many laboratory manipulations, both genetic and environmental, can lead to significant life extension. All or…”
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Hormesis--a new hope for ageing studies or a poor second to genetics? by Lithgow, G J

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Mortality Rates in a Genetically Heterogeneous Population of Caenorhabditis elegans by Brooks, Anne, Lithgow, Gordon J., Johnson, Thomas E.

“…Age-specific mortality rates in isogenic populations of the nematode Caenorhabditis elegans increase exponentially throughout life. In genetically…”
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Evolution of lifespan in C. elegans by WALKER, D. W, MCCOLL, G, JENKINS, N. L, HARRIS, J, LITHGOW, G. J

“…It was proposed almost 50 years ago that ageing is non-adaptive and is the consequence of a decline in the force of natural selection with age. This led to the…”
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Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans by Melov, S., Lithgow, G. J., Fischer, D. R., Tedesco, P. M., Johnson, T. E.

“…ABSTRACT We have developed a long-extension-PCR strategy which amplifies approximately half of the mitochondrial genome (6.3 kb)of Caenorhabditis elegans using…”
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Longevity and heavy metal resistance in daf‐2 and age‐1 long‐lived mutants of Caenorhabditis elegans by BARSYTE, DALIA, LOVEJOY, DAVID A., LITHGOW, GORDON J.

“…ABSTRACT In the nematode CAENORHABDITIS ELEGANS, dauer formation, stress resistance, and longevity are determined in part by DAF‐2 (insulin receptor‐like…”
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An automated high-throughput assay for survival of the nematode Caenorhabditis elegans by Gill, Matthew S, Olsen, Anders, Sampayo, James N, Lithgow, Gordon J

“…Many genetic or environmental manipulations that extend life span in the nematode Caenorhabditis elegans ( C. elegans) also enhance survival following acute…”
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Stress Biology and Aging Mechanisms: Toward Understanding the Deep Connection Between Adaptation to Stress and Longevity by Epel, Elissa S., Lithgow, Gordon J.

“…The rate of biological aging is modulated in part by genes interacting with stressor exposures. Basic research has shown that exposure to short-term stress can…”
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C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span by McColl, Gawain, Vantipalli, Maithili C, Lithgow, Gordon J

“…ABSTRACTThe mammalian Ku heterodimer has important roles in DNA double strand break repair, telomere maintenance, cell cycle checkpoint‐arrest, tumor…”
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Stress response and aging in Caenorhabditis elegans by Lithgow, G J

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Invertebrate gerontology: the age mutations of Caenorhabditis elegans by Lithgow, G J

“…Ageing is a complex phenomenon which remains a major challenge to modern biology. Although the evolutionary biology of ageing is well understood, the…”
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Thermotolerance of a long-lived mutant of Caenorhabditis elegans by Lithgow, G J, White, T M, Hinerfeld, D A, Johnson, T E

“…Age-synchronous cohorts of Caenorhabditis elegans were grown at 20 degrees C, then stressed at 30 degrees C or 35 degrees C. Intrinsic thermotolerance of wild…”
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M142.2 ( cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape by Muriel, Joaquin M, Brannan, Mike, Taylor, Kathryn, Johnstone, Iain L, Lithgow, Gordon J, Tuckwell, Danny

“…The cuticle of the nematode Caenorhabditis elegans is a collagenous extracellular matrix which forms the exoskeleton and defines the shape of the worm. We have…”
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P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans by Babar, P, Adamson, C, Walker, G A, Walker, D W, Lithgow, G J

“…The effects of 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), an inhibitor of mammalian phosphatidylinositol 3-OH kinase, was tested on an…”
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