Search Results - "Liszczak, Glen"

The Molecular Basis for Histone H4- and H2A-Specific Amino-Terminal Acetylation by NatD by Magin, Robert S., Liszczak, Glen P., Marmorstein, Ronen

“…N-terminal acetylation is among the most common protein modifications in eukaryotes and is mediated by evolutionarily conserved N-terminal acetyltransferases…”
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Mutations linked to neurological disease enhance self-association of low-complexity protein sequences by Zhou, Xiaoming, Sumrow, Lily, Tashiro, Kyuto, Sutherland, Lillian, Liu, Daifei, Qin, Tian, Kato, Masato, Liszczak, Glen, McKnight, Steven L

“…Protein domains of low sequence complexity do not fold into stable, three-dimensional structures. Nevertheless, proteins with these sequences assist in many…”
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A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing by Dao, Hai T., Dul, Barbara E., Dann, Geoffrey P., Liszczak, Glen P., Muir, Tom W.

“…Recent studies have implicated the nucleosome acidic patch in the activity of ATP-dependent chromatin remodeling machines. We used a photocrosslinking-based…”
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Implications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal ortholog by Liszczak, Glen, Marmorstein, Ronen

“…Amino-terminal acetylation is a ubiquitous modification in eukaryotes that is involved in a growing number of biological processes.There are six known…”
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Acetylation blocks DNA damage–induced chromatin ADP-ribosylation by Liszczak, Glen, Diehl, Katharine L., Dann, Geoffrey P., Muir, Tom W.

“…Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for…”
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ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference by Dann, Geoffrey P., Liszczak, Glen P., Bagert, John D., Müller, Manuel M., Nguyen, Uyen T. T., Wojcik, Felix, Brown, Zachary Z., Bos, Jeffrey, Panchenko, Tatyana, Pihl, Rasmus, Pollock, Samuel B., Diehl, Katharine L., Allis, C. David, Muir, Tom W.

“…A high-throughput approach using a DNA-barcoded nucleosome library shows that ISWI chromatin remodellers can distinguish between differently modified…”
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Molecular basis for N-terminal acetylation by the heterodimeric NatA complex by Liszczak, Glen, Goldberg, Jacob M, Foyn, Håvard, Petersson, E James, Arnesen, Thomas, Marmorstein, Ronen

“…N-terminal acetylases catalyze the cotranslational modification of myriad proteins. Structural and mutational analyses of the NatA complex, comprising a…”
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A two-state activation mechanism controls the histone methyltransferase Suv39h1 by Müller, Manuel M, Fierz, Beat, Bittova, Lenka, Liszczak, Glen, Muir, Tom W

“…Suv39h1 is a histone methyltransferase that methylates H3K9 residues in heterochromatic regions of the genome. An approach using semisynthetic chromatin…”
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Transiently structured head domains control intermediate filament assembly by Zhou, Xiaoming, Lin, Yi, Kato, Masato, Mori, Eiichiro, Liszczak, Glen, Sutherland, Lillian, Sysoev, Vasiliy O., Murray, Dylan T., Tycko, Robert, McKnight, Steven L.

“…Low complexity (LC) head domains 92 and 108 residues in length are, respectively, required for assembly of neurofilament light (NFL) and desmin intermediate…”
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Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1 by Bacic, Luka, Gaullier, Guillaume, Mohapatra, Jugal, Mao, Guanzhong, Brackmann, Klaus, Panfilov, Mikhail, Liszczak, Glen, Sabantsev, Anton, Deindl, Sebastian

“…The chromatin remodeler ALC1 is activated by DNA damage-induced poly(ADP-ribose) deposited by PARP1/PARP2 and their co-factor HPF1. ALC1 has emerged as a…”
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Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling by Mohapatra, Jugal, Tashiro, Kyuto, Beckner, Ryan L, Sierra, Jorge, Kilgore, Jessica A, Williams, Noelle S, Liszczak, Glen

“…Serine ADP-ribosylation (ADPr) is a DNA damage-induced post-translational modification catalyzed by the PARP1/2:HPF1 complex. As the list of PARP1/2:HPF1…”
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Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific Acetylation by Liszczak, Glen, Arnesen, Thomas, Marmorstein, Ronen

“…The co-translational modification of N-terminal acetylation is ubiquitous among eukaryotes and has been reported to have a wide range of biological effects…”
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Genomic targeting of epigenetic probes using a chemically tailored Cas9 system by Liszczak, Glen P., Brown, Zachary Z., Kim, Samuel H., Oslund, Rob C., David, Yael, Muir, Tom W.

“…Recent advances in the field of programmable DNA-binding proteins have led to the development of facile methods for genomic localization of genetically…”
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Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1 by Rivera-Colón, Yadilette, Maguire, Andrew, Liszczak, Glen P., Olia, Adam S., Marmorstein, Ronen

“…Protein acetylation is a prevalent posttranslational modification that is regulated by diverse acetyltransferase enzymes. Although histone acetyltransferases…”
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Specificity and versatility of substrate binding sites in four catalytic domains of human N-terminal acetyltransferases by Grauffel, Cédric, Abboud, Angèle, Liszczak, Glen, Marmorstein, Ronen, Arnesen, Thomas, Reuter, Nathalie

“…Nt-acetylation is among the most common protein modifications in eukaryotes. Although thought for a long time to protect proteins from degradation, the role of…”
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Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor by Bowers, Erin M., Yan, Gai, Mukherjee, Chandrani, Orry, Andrew, Wang, Ling, Holbert, Marc A., Crump, Nicholas T., Hazzalin, Catherine A., Liszczak, Glen, Yuan, Hua, Larocca, Cecilia, Saldanha, S. Adrian, Abagyan, Ruben, Sun, Yan, Meyers, David J., Marmorstein, Ronen, Mahadevan, Louis C., Alani, Rhoda M., Cole, Philip A.

“…The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events…”
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Nucleic Acid‐Barcoding Technologies: Converting DNA Sequencing into a Broad‐Spectrum Molecular Counter by Liszczak, Glen, Muir, Tom W.

“…The emergence of high‐throughput DNA sequencing technologies sparked a revolution in the field of genomics that has rippled into many branches of the life and…”
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Abstract 2169 Probing hidden structure within intrinsically disordered protein domains with chiral mutagenesis by Beckner, Ryan, Zhou, Xiaoming, Carter, Christien, Gu, Jinge, Valadez, Catherine, McKnight, Steven, Liszczak, Glen

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Abstract 2310 Unexpected mechanisms of ETV6 dysfunction in hematologic disease by Liszczak, Glen, McConville, Michael, Thomas, Toby, Beckner, Ryan, Valadez, Catherine, Chook, Yuh Min, Chung, Stephen

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Abstract 2164 Familial Thrombocytopenia-Associated Germline ETV6 P214L Mutation Results in XPO1-Mediated Nuclear Export by McConville, Michael, McConville, Michael, Thomas, Toby, Beckner, Ryan, Valadez, Catherine, Chook, Yuh Min, Chung, Stephen, Liszczak, Glen

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