Search Results - "Liss, Andrew S"

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism by Patra, Krushna C., Kato, Yasutaka, Mizukami, Yusuke, Widholz, Sebastian, Boukhali, Myriam, Revenco, Iulia, Grossman, Elizabeth A., Ji, Fei, Sadreyev, Ruslan I., Liss, Andrew S., Screaton, Robert A., Sakamoto, Kei, Ryan, David P., Mino-Kenudson, Mari, Castillo, Carlos Fernandez-del, Nomura, Daniel K., Haas, Wilhelm, Bardeesy, Nabeel

“…G protein α s (GNAS) mediates receptor-stimulated cAMP signalling, which integrates diverse environmental cues with intracellular responses. GNAS is…”
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Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target by Franses, Joseph W., Philipp, Julia, Missios, Pavlos, Bhan, Irun, Liu, Ann, Yashaswini, Chittampalli, Tai, Eric, Zhu, Huili, Ligorio, Matteo, Nicholson, Benjamin, Tassoni, Elizabeth M., Desai, Niyati, Kulkarni, Anupriya S., Szabolcs, Annamaria, Hong, Theodore S., Liss, Andrew S., Fernandez-del Castillo, Carlos, Ryan, David P., Maheswaran, Shyamala, Haber, Daniel A., Daley, George Q., Ting, David T.

“…Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination. Characterization of rare, heterogeneous circulating tumor cells (CTCs)…”
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Extracellular vesicle analysis of plasma allows differential diagnosis of atypical pancreatic serous cystadenoma by Yang, Katherine S., O’Shea, Aileen, Zelga, Piotr, Liss, Andrew S., Del Castillo, Carlos Fernandez, Weissleder, Ralph

“…Increased use of cross-sectional imaging has resulted in frequent detection of incidental cystic pancreatic lesions. Serous cystadenomas (SCAs) are benign…”
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Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas by Rovira, Meritxell, Scott, Sherri-Gae, Liss, Andrew S, Jensen, Jan, Thayer, Sarah P, Leach, Steven D

“…The question of whether dedicated progenitor cells exist in adult vertebrate pancreas remains controversial. Centroacinar cells and terminal duct (CA/TD) cells…”
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Simultaneous targeting of primary tumor, draining lymph node, and distant metastases through high endothelial venule-targeted delivery by Jiang, Liwei, Jung, Sungwook, Zhao, Jing, Kasinath, Vivek, Ichimura, Takaharu, Joseph, John, Fiorina, Paolo, Liss, Andrew S., Shah, Khalid, Annabi, Nasim, Joshi, Nitin, Akama, Tomoya O., Bromberg, Jonathan S., Kobayashi, Motohiro, Uchimura, Kenji, Abdi, Reza

“…Cancer patients with malignant involvement of tumor-draining lymph nodes (TDLNs) and distant metastases have the poorest prognosis. A drug delivery platform…”
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Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice by Yamaguchi, Junpei, Mino-Kenudson, Mari, Liss, Andrew S, Chowdhury, Sanjib, Wang, Timothy C, Castillo, Carlos Fernández-del, Lillemoe, Keith D, Warshaw, Andrew L, Thayer, Sarah P

“…Background & Aims Little is known about the origin of pancreatic intraductal papillary mucinous neoplasms (IPMN). Pancreatic duct glands (PDGs) are gland-like…”
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Tumor engraftment in patient-derived xenografts of pancreatic ductal adenocarcinoma is associated with adverse clinicopathological features and poor survival by Pergolini, Ilaria, Morales-Oyarvide, Vicente, Mino-Kenudson, Mari, Honselmann, Kim C, Rosenbaum, Matthew W, Nahar, Sabikun, Kem, Marina, Ferrone, Cristina R, Lillemoe, Keith D, Bardeesy, Nabeel, Ryan, David P, Thayer, Sarah P, Warshaw, Andrew L, Fernández-Del Castillo, Carlos, Liss, Andrew S

“…Patient-derived xenograft (PDX) tumors are powerful tools to study cancer biology. However, the ability of PDX tumors to model the biological and histological…”
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Circulating Epithelial Cells in Patients with Pancreatic Lesions: Clinical and Pathologic Findings by Cauley, Christy E., MD, Pitman, Martha B., MD, Zhou, Jiahua, MD, Perkins, James, MD, Kuleman, Birte, MD, Liss, Andrew S., PhD, Fernandez-del Castillo, Carlos, MD, Warshaw, Andrew L., MD, FACS, Lillemoe, Keith D., MD, FACS, Thayer, Sarah P., MD, PhD, FACS

“…Background Circulating epithelial cell (CEC) isolation has provided diagnostic and prognostic information for a variety of cancers, previously supporting their…”
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KRAS mutations in pancreatic circulating tumor cells: a pilot study by Kulemann, Birte, Liss, Andrew S., Warshaw, Andrew L., Seifert, Sindy, Bronsert, Peter, Glatz, Torben, Pitman, Martha B., Hoeppner, Jens

“…Pancreatic ductal adenocarcinoma (PDAC) is most often diagnosed in a metastatic stage. Circulating tumor cells (CTC) in the blood are hypothesized as the means…”
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Pancreatic duct glands (PDGs) are a progenitor compartment responsible for pancreatic ductal epithelial repair by Yamaguchi, Junpei, Liss, Andrew S., Sontheimer, Alexandra, Mino-Kenudson, Mari, Castillo, Carlos Fernández-del, Warshaw, Andrew L., Thayer, Sarah P.

“…Pancreatic duct glands (PDGs) have molecular features known to mark stem cell niches, but their function remains to be determined. To investigate the role of…”
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A fast, simple, and cost-effective method of expanding patient-derived xenograft mouse models of pancreatic ductal adenocarcinoma by Liu, Zhenyang, Ahn, Michael Ho-Young, Kurokawa, Tomohiro, Ly, Amy, Zhang, Gong, Wang, Fuyou, Yamada, Teppei, Sadagopan, Ananthan, Cheng, Jane, Ferrone, Cristina R, Liss, Andrew S, Honselmann, Kim C, Wojtkiewicz, Gregory R, Ferrone, Soldano, Wang, Xinhui

“…Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original…”
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Survival in ampullary cancer: Potential role of different KRAS mutations by Valsangkar, Nakul P., MD, Ingkakul, Thun, MD, Correa-Gallego, Camilo, MD, Mino-Kenudson, Mari, MD, Masia, Ricard, MD, PhD, Lillemoe, Keith D., MD, Castillo, Carlos Fernández-del, MD, Warshaw, Andrew L., MD, Liss, Andrew S., PhD, Thayer, Sarah P., MD, PhD

“…Objective The prognosis of ampullary adenocarcinoma (AA) usually is favorable; however, a subset of AA have poor biology and outcomes similar to pancreatic…”
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A method for fixing and paraffin embedding tissue to retain the natural fluorescence of reporter proteins by Nakagawa, Akifumi, Alt, Kate Von, Lillemoe, Keith D, Castillo, Carlos Fernández-Del, Warshaw, Andrew L, Liss, Andrew S

“…Green fluorescent protein (GFP) and its derivatives are routinely employed as surrogate markers for gene expression and lineage tracing in genetically…”
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Selective and reversible suppression of intestinal stem cell differentiation by pharmacological inhibition of BET bromodomains by Nakagawa, Akifumi, Adams, Curtis E., Huang, Yinshi, Hamarneh, Sulaiman R., Liu, Wei, Von Alt, Kate N., Mino-Kenudson, Mari, Hodin, Richard A., Lillemoe, Keith D., Fernández-del Castillo, Carlos, Warshaw, Andrew L., Liss, Andrew S.

“…Absorptive and secretory cells of the small intestine are derived from a single population of Lgr5-expressing stem cells. While key genetic pathways required…”
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Sonic Hedgehog in pancreatic cancer: From bench to bedside, then back to the bench by Rosow, David E., MD, Liss, Andrew S., PhD, Strobel, Oliver, MD, Fritz, Stefan, MD, Bausch, Dirk, MD, Valsangkar, Nakul P., MD, Alsina, Janivette, MD, PhD, Kulemann, Birte, MD, Park, Joo Kyung, MD, Yamaguchi, Junpei, MD, LaFemina, Jennifer, MD, Thayer, Sarah P., MD, PhD

“…Developmental genes are known to regulate cell proliferation, migration, and differentiation; thus, it comes as no surprise that the misregulation of…”
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A method for fixing and paraffin embedding tissue to retain the natural fluorescence of reporter proteins by Akifumi Nakagawa, Kate Von Alt, Keith D. Lillemoe, Carlos Fernández-del Castillo, Andrew L. Warshaw, Andrew S. Liss

“…Protocol Summary Here we present an ethanol fixation protocol that allows for the direct visualization of the natural fluorescence of reporter proteins while…”
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Recent Advances in Chromatin Mechanisms Controlling Pancreatic Carcinogenesis by Hank, Thomas, Liss, Andrew

“…Pancreatic ductal adenocarcinoma has a heterogeneous genetic landscape, marked by frequent mutation of KRAS, CDKN2A, TP53, and SMAD4, resulting in poor…”
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Extracellular Vesicle Analysis Allows for Identification of Invasive IPMN by Yang, Katherine S., Ciprani, Debora, O’Shea, Aileen, Liss, Andrew S., Yang, Robert, Fletcher-Mercaldo, Sarah, Mino-Kenudson, Mari, Fernández-del Castillo, Carlos, Weissleder, Ralph

“…Advances in cross-sectional imaging have resulted in increased detection of intraductal papillary mucinous neoplasms (IPMNs), and their management remains…”
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Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway by Kawabata, Hidemasa, Ono, Yusuke, Tamamura, Nobue, Oyama, Kyohei, Ueda, Jun, Sato, Hiroki, Takahashi, Kenji, Taniue, Kenzui, Okada, Tetsuhiro, Fujibayashi, Syugo, Hayashi, Akihiro, Goto, Takuma, Enomoto, Katsuro, Konishi, Hiroaki, Fujiya, Mikihiro, Miyakawa, Keita, Tanino, Mishie, Nishikawa, Yuji, Koga, Daisuke, Watanabe, Tsuyoshi, Maeda, Chiho, Karasaki, Hidenori, Liss, Andrew S., Mizukami, Yusuke, Okumura, Toshikatsu

“…Background Mutations in GNAS drive pancreatic tumorigenesis and frequently occur in intraductal papillary mucinous neoplasm (IPMN); however, their value as a…”
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The Extracellular Matrix and Pancreatic Cancer: A Complex Relationship by Weniger, Maximilian, Honselmann, Kim C, Liss, Andrew S

“…Pancreatic ductal adenocarcinoma (PDAC) has an extraordinarily dense fibrotic stroma that impedes tumor perfusion and delivery of anticancer drugs. Since the…”
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