Search Results - "Liskamp, Rob M. J."
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Synthesis and Applications of Biomedical and Pharmaceutical Polymers via Click Chemistry Methodologies
Published in Bioconjugate chemistry (18-11-2009)“…In this review, the synthesis and application of biomedical and pharmaceutical polymers synthesized via the copper(I)-catalyzed alkyne-azide cycloaddition, the…”
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2
Tailoring Polyethers for Post-polymerization Functionalization by Cross Metathesis
Published in Organic letters (20-04-2018)“…Olefin cross metathesis is reported for the first time to attach small molecules to a range of novel polyethers with a poly(ethylene glycol) backbone and…”
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3
Synthesis and Characterization of Enzymatically Biodegradable PEG and Peptide-Based Hydrogels Prepared by Click Chemistry
Published in Biomacromolecules (14-06-2010)“…Herein we describe the synthesis and rheological characterization of a series of enzymatically sensitive PEG and peptide-based hydrogels by the Cu(I)-catalyzed…”
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4
Broad-Spectrum Antimalarial Activity of Peptido Sulfonyl Fluorides, a New Class of Proteasome Inhibitors
Published in Antimicrobial Agents and Chemotherapy (01-08-2013)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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5
Polar Hinges as Functionalized Conformational Constraints in (Bi)cyclic Peptides
Published in Chembiochem : a European journal of chemical biology (16-02-2017)“…Two polar hinges for cyclization of peptides have been developed, leading to bicyclic peptides and cyclized peptides with improved solubility and biological…”
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6
The Vancomycin−Nisin(1−12) Hybrid Restores Activity against Vancomycin Resistant Enterococci
Published in Biochemistry (Easton) (02-12-2008)“…Lipid II is a crucial component in bacterial cell wall synthesis [Breukink, E., et al. (1999) Science 286, 2361−2364]. It is the target of a number of…”
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Enhanced Membrane Pore Formation by Multimeric/Oligomeric Antimicrobial Peptides
Published in Biochemistry (Easton) (20-11-2007)“…The pore-forming antibacterial peptide magainin 2 was made divalent, tetravalent, and octavalent via a copper(I)-mediated 1−3 dipolar cycloaddition reaction…”
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8
Potent and Highly Selective Inhibitors of the Proteasome Trypsin-like Site by Incorporation of Basic Side Chain Containing Amino Acid Derived Sulfonyl Fluorides
Published in Journal of medicinal chemistry (28-06-2018)“…A unique category of basic side chain containing amino acid derived sulfonyl fluorides (SFs) has been synthesized for incorporation into new proteasome…”
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9
Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics
Published in Cell chemical biology (16-08-2018)“…Prolyl oligopeptidase (POP), a serine protease highly expressed in the brain, has recently emerged as an enticing therapeutic target for the treatment of…”
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10
Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap
Published in Bioorganic & medicinal chemistry (01-04-2011)“…We have designed and synthesized novel irreversible serine protease inhibitors containing aliphatic sulfonyl fluorides as an electrophilic trap. These…”
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11
Synthesis, Antimicrobial Activity, and Membrane Permeabilizing Properties of C‑Terminally Modified Nisin Conjugates Accessed by CuAAC
Published in Bioconjugate chemistry (18-12-2013)“…Functionalization of the lantibiotic nisin with fluorescent reporter molecules is highly important for the understanding of its mode of action as a potent…”
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12
A proteinaceous fraction of wheat bran may interfere in the attachment of enterotoxigenic E. coli K88 (F4+) to porcine epithelial cells
Published in PloS one (13-08-2014)“…Wheat bran (WB) from Triticum aestivum has many beneficial effects on human health. To the best of our knowledge, very little has been published about its…”
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13
New properties of wheat bran: anti‐biofilm activity and interference with bacteria quorum‐sensing systems
Published in Environmental microbiology (01-05-2014)“…Some plant extracts, have been demonstrated to interfere with the microbial metabolism of several pathogenic bacteria. Within this antimicrobial properties it…”
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14
TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide-alkyne cycloaddition reactions
Published in Chemical science (Cambridge) (10-08-2020)“…We describe the development of TMTH- S ulfox I mine (TMTH SI ) as a superior click reagent. This reagent combines a great reactivity, with small size and low…”
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15
Versatile convergent synthesis of a three peptide loop containing protein mimic of whooping cough pertactin by successive Cu(I)-catalyzed azide alkyne cycloaddition on an orthogonal alkyne functionalized TAC-scaffold
Published in Journal of peptide science (01-04-2014)“…Synthetic mimics of discontinuous epitopes may have a wide range of potential applications, including synthetic vaccines and inhibition of protein–protein…”
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Resin-Bound Sulfonyl Azides: Efficient Loading and Activation Strategy for the Preparation of the N-Acyl Sulfonamide Linker
Published in Journal of organic chemistry (08-06-2007)“…This paper describes an optimized protocol for the efficient loading of resin-bound aminoethane sulfonyl azides by either Boc- or Fmoc-protected amino…”
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17
Peptides and Proteins as a Continuing Exciting Source of Inspiration for Peptidomimetics
Published in Chembiochem : a European journal of chemical biology (25-07-2011)“…Despite their enormous diversity in biological function and structure, peptides and proteins are endowed with properties that have induced and stimulated the…”
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18
Inhibition of Streptococcus suis Adhesion by Dendritic Galabiose Compounds at Low Nanomolar Concentration
Published in Journal of medicinal chemistry (16-12-2004)“…A series of mono-, di-, and tetravalent galabiose (Galalpha1-4Gal) compounds were synthesized in good yields by coupling of a general carboxylic acid-bearing…”
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19
Molecular Construction of Sulfonamide Antisense Oligonucleotides
Published in Journal of organic chemistry (06-09-2019)“…An efficient and scalable synthesis of new oligonucleotide monomers was developed for replacement of the phosphodiester backbone of RNA by a…”
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20
Characterization and Activity of an Immobilized Antimicrobial Peptide Containing Bactericidal PEG-Hydrogel
Published in Biomacromolecules (08-09-2014)“…A single step immobilization-polymerization strategy of a highly active antimicrobial peptide into a soft hydrogel network on a poly(ethylene terephthalate)…”
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