Search Results - "Lisignoli, Gina"

Biomaterials: Foreign Bodies or Tuners for the Immune Response? by Mariani, Erminia, Lisignoli, Gina, Borzì, Rosa Maria, Pulsatelli, Lia

“…The perspectives of regenerative medicine are still severely hampered by the host response to biomaterial implantation, despite the robustness of technologies…”
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Adipose Mesenchymal Stromal Cell‐Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose‐Escalation Trial by Pers, Yves-Marie, Rackwitz, Lars, Ferreira, Rosanna, Pullig, Oliver, Delfour, Christophe, Barry, Frank, Sensebe, Luc, Casteilla, Louis, Fleury, Sandrine, Bourin, Philippe, Noël, Danièle, Canovas, François, Cyteval, Catherine, Lisignoli, Gina, Schrauth, Joachim, Haddad, Daniel, Domergue, Sophie, Noeth, Ulrich, Jorgensen, Christian

“…This phase I clinical trial evaluated the safety and clinical efficacy of adipose‐derived stromal cells (ASCs) in osteoarthritis. Eighteen patients with severe…”
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Adipose‐Derived Mesenchymal Stem Cells Exert Antiinflammatory Effects on Chondrocytes and Synoviocytes From Osteoarthritis Patients Through Prostaglandin E2 by Manferdini, Cristina, Maumus, Marie, Gabusi, Elena, Piacentini, Anna, Filardo, Giuseppe, Peyrafitte, Julie‐Anne, Jorgensen, Christian, Bourin, Philippe, Fleury‐Cappellesso, Sandrine, Facchini, Andrea, Noël, Danièle, Lisignoli, Gina

“…Objective To examine the effect of different sources of Good Manufacturing Practice clinical grade adipose‐derived mesenchymal stem cells (AD‐MSCs) on…”
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From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells by Manferdini, Cristina, Paolella, Francesca, Gabusi, Elena, Silvestri, Ylenia, Gambari, Laura, Cattini, Luca, Filardo, Giuseppe, Fleury-Cappellesso, Sandrine, Lisignoli, Gina

“…The aim of the study was to characterize synovial cells from OA synovium with low-grade and moderate-grade synovitis and to define the role of synovial…”
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Complement Expression and Activation in Osteoarthritis Joint Compartments by Assirelli, Elisa, Pulsatelli, Lia, Dolzani, Paolo, Mariani, Erminia, Lisignoli, Gina, Addimanda, Olga, Meliconi, Riccardo

“…To investigate complement(C) factors(F) and their activation fragments expression in OA joint tissues. Immunohistochemistry and quantitative imaging were…”
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Specific concentration of hyaluronan amide derivative induces osteogenic mineralization of human mesenchymal stromal cells: Evidence of RUNX2 and COL1A1 genes modulation by Paolella, Francesca, Gabusi, Elena, Manferdini, Cristina, Schiavinato, Antonella, Lisignoli, Gina

“…Hyaluronic acid (HA) is an ideal material for tissue regeneration. The aim of this study was to investigate whether a hyaluronan amide derivative (HAD) can…”
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Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism by Gambari, Laura, Lisignoli, Gina, Cattini, Luca, Manferdini, Cristina, Facchini, Andrea, Grassi, Francesco

“…Hydrogen sulfide (H2S), which recently emerged as a potent regulator of tissues and organs, is broadly produced in mammalian cells but whether it can regulate…”
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Bone Regeneration Improves with Mesenchymal Stem Cell Derived Extracellular Vesicles (EVs) Combined with Scaffolds: A Systematic Review by Re, Federica, Gabusi, Elena, Manferdini, Cristina, Russo, Domenico, Lisignoli, Gina

“…Scaffolds associated with mesenchymal stem cell (MSC) derivatives, such as extracellular vesicles (EVs), represent interesting carriers for bone regeneration…”
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Arthroscopic device with bendable tip for the controlled extrusion of hydrogels on cartilage defects by Guarnera, Daniele, Restaino, Francesco, Vannozzi, Lorenzo, Trucco, Diego, Mazzocchi, Tommaso, Worwąg, Michał, Gapinski, Tomasz, Lisignoli, Gina, Zaffagnini, Stefano, Russo, Alessandro, Ricotti, Leonardo

“…Advanced tools for the in situ treatment of articular cartilage lesions are attracting a growing interest in both surgery and bioengineering communities. The…”
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Osteoarthritic Milieu Affects Adipose‐Derived Mesenchymal Stromal Cells by Manferdini, Cristina, Paolella, Francesca, Gabusi, Elena, Cattini, Luca, Rojewski, Markus, Schrezenmeier, Hubert, Addimanda, Olga, Meliconi, Riccardo, Lisignoli, Gina

“…ABSTRACT The objective of this study was to define the effects of osteoarthritic (OA) milieu on good manufactured practice‐adipose‐derived mesenchymal stromal…”
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Wear Behavior Characterization of Hydrogels Constructs for Cartilage Tissue Replacement by Affatato, Saverio, Trucco, Diego, Taddei, Paola, Vannozzi, Lorenzo, Ricotti, Leonardo, Nessim, Gilbert Daniel, Lisignoli, Gina

“…This paper aims to characterize the wear behavior of hydrogel constructs designed for human articular cartilage replacement. To this purpose, poly (ethylene…”
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The effect of silk–gelatin bioink and TGF-β3 on mesenchymal stromal cells in 3D bioprinted chondrogenic constructs: A proteomic study by Chawla, Shikha, Desando, Giovanna, Gabusi, Elena, Sharma, Aarushi, Trucco, Diego, Chakraborty, Juhi, Manferdini, Cristina, Petretta, Mauro, Lisignoli, Gina, Ghosh, Sourabh

“…Major limitation of 3D bioprinting is the poor understanding of the role of bioink in modulating molecular signaling pathways. Phenotypically stable engineered…”
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3D gelatin-chitosan hybrid hydrogels combined with human platelet lysate highly support human mesenchymal stem cell proliferation and osteogenic differentiation by Re, Federica, Sartore, Luciana, Moulisova, Vladimira, Cantini, Marco, Almici, Camillo, Bianchetti, Andrea, Chinello, Clizia, Dey, Kamol, Agnelli, Silvia, Manferdini, Cristina, Bernardi, Simona, Lopomo, Nicola F., Sardini, Emilio, Borsani, Elisa, Rodella, Luigi F., Savoldi, Fabio, Paganelli, Corrado, Guizzi, Pierangelo, Lisignoli, Gina, Magni, Fulvio, Salmeron-Sanchez, Manuel, Russo, Domenico

“…Bone marrow and adipose tissue human mesenchymal stem cells were seeded in highly performing 3D gelatin–chitosan hybrid hydrogels of varying chitosan content…”
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Editorial: Methodologies to improve the performance of chondrocytes for cartilage repair and regeneration by Lisignoli, Gina, Nalesso, Giovanna, Barbero, Andrea

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Collagen type XV and the ‘osteogenic status’ by Lisignoli, Gina, Lambertini, Elisabetta, Manferdini, Cristina, Gabusi, Elena, Penolazzi, Letizia, Paolella, Francesca, Angelozzi, Marco, Casagranda, Veronica, Piva, Roberta

“…We have previously demonstrated that collagen type XV (ColXV) is a novel bone extracellular matrix (ECM) protein. It is well known that the complex mixture of…”
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Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis by Maumus, Marie, Manferdini, Cristina, Toupet, Karine, Chuchana, Paul, Casteilla, Louis, Gachet, Mélanie, Jorgensen, Christian, Lisignoli, Gina, Noël, Danièle

“…Assuming that mesenchymal stem cells (MSCs) respond to the osteoarthritic joint environment to exert a chondroprotective effect, we aimed at investigating the…”
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Mesenchymal stromal cells from a progressive pseudorheumatoid dysplasia patient show altered osteogenic differentiation by Pulsatelli, Lia, Manferdini, Cristina, Gabusi, Elena, Mariani, Erminia, Ursini, Francesco, Ciaffi, Jacopo, Meliconi, Riccardo, Lisignoli, Gina

“…Progressive pseudorheumatoid dysplasia (PPRD) is a rare autosomal recessive non-inflammatory skeletal disease with childhood onset and is characterized by a…”
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Mesenchymal Stromal Cells Laden in Hydrogels for Osteoarthritis Cartilage Regeneration: A Systematic Review from In Vitro Studies to Clinical Applications by Manferdini, Cristina, Gabusi, Elena, Saleh, Yasmin, Lenzi, Enrico, D'Atri, Giovanni, Ricotti, Leonardo, Lisignoli, Gina

“…This systematic review is focused on the main characteristics of the hydrogels used for embedding the mesenchymal stromal cells (MSCs) in in vitro/ex vivo…”
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Autophagy Is a Crucial Path in Chondrogenesis of Adipose-Derived Mesenchymal Stromal Cells Laden in Hydrogel by Gabusi, Elena, Lenzi, Enrico, Manferdini, Cristina, Dolzani, Paolo, Columbaro, Marta, Saleh, Yasmin, Lisignoli, Gina

“…Autophagy is a cellular process that contributes to the maintenance of cell homeostasis through the activation of a specific path, by providing the necessary…”
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RGD-Functionalized Hydrogel Supports the Chondrogenic Commitment of Adipose Mesenchymal Stromal Cells by Manferdini, Cristina, Trucco, Diego, Saleh, Yasmin, Gabusi, Elena, Dolzani, Paolo, Lenzi, Enrico, Vannozzi, Lorenzo, Ricotti, Leonardo, Lisignoli, Gina

“…Articular cartilage is known to have limited intrinsic self-healing capacity when a defect or a degeneration process occurs. Hydrogels represent promising…”
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