Search Results - "Lishi, Sun"

PD-1/PD-L1, MDSC Pathways, and Checkpoint Inhibitor Therapy in Ph (-) Myeloproliferative Neoplasm: A Review by Wang, Jen-Chin, Sun, Lishi

“…There has been significant progress in immune checkpoint inhibitor (CPI) therapy in many solid tumor types. However, only a single failed study has been…”
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TLR2 Derangements Likely Play a Significant Role in the Inflammatory Response and Thrombosis in Patients with Ph (-) Classical Myeloproliferative Neoplasm by Wang, Jen Chin, Shi, Guanfang, Chen, Chi, Wong, Ching, Gotlieb, Vladimir, Joseph, Gardith, Nair, Kiron V, Boyapati, Lakshmi, Ladan, Enayati, Symanowski, James T, Sun, Lishi

“…We investigated the role of toll-like receptors (TLRs) in inflammatory pathways in Philadelphia chromosome-negative myeloproliferative neoplasms ( (-)MPNs)…”
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SMARCA4-Deficient Undifferentiated Tumor of Lung Mass—A Rare Tumor With the Rarer Occurrence of Brain Metastasis: A Case Report and Review of the Literature by Yadav, Ruchi, Sun, Lishi, Salyana, Muhammad, Eric, Minkin, Gotlieb, Vladimir, Wang, Jen C.

“…Among thoracic tumors, these include subsets of a relatively newly described and yet to be fully characterized tumor entity: SMARCA4-deficient Undifferentiated…”
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B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses by Lin, Pei-Yi, Sun, Lishi, Thibodeaux, Suzanne R, Ludwig, Sara M, Vadlamudi, Ratna K, Hurez, Vincent J, Bahar, Rumana, Kious, Mark J, Livi, Carolina B, Wall, Shawna R, Chen, Lieping, Zhang, Bin, Shin, Tahiro, Curiel, Tyler J

“…CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are immunopathogenic in cancers by impeding tumor-specific immunity. B7-homologue 1 (B7-H1) (CD274) is a…”
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Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice by HUREZ, Vincent, DANIEL, Benjamin J, WALL, Shawna, BRUMLIK, Michael J, SHIN, Tahiro, BIN ZHANG, CURIEL, Tyler J, LISHI SUN, LIU, Ai-Jie, LUDWIG, Sara M, KIOUS, Mark J, THIBODEAUX, Suzanne R, PANDESWARA, Srilakshmi, MURTHY, Kruthi, LIVI, Carolina B

“…Although cancer tends to affect the elderly, most preclinical studies are carried out in young subjects. In this study, we developed a melanoma-specific cancer…”
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eRapa Restores a Normal Life Span in a FAP Mouse Model by HASTY, Paul, LIVI, Carolina B, LISHI SUN, HUREZ, Vincent, CURIEL, Tyler J, ZELTON DAVE SHARP, DODDS, Sherry G, JONES, Diane, STRONG, Randy, JAVORS, Martin, FISCHER, Kathleen E, SLOANE, Lauren, MURTHY, Kruthi, HUBBARD, Gene

“…Mutation of a single copy of the adenomatous polyposis coli (APC) gene results in familial adenomatous polyposis (FAP), which confers an extremely high risk…”
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Hemorrhagic Brain Metastasis as an Initial Presentation of Hepatocellular Carcinoma in a Patient With Alcohol-Related Liver Cirrhosis: A Case Report and Review of Literature by Thida, Chan, Pokhrel, Akriti, Sun, Lishi, Wu, Richard, Jaswani, Vijay, Wang, Jen C.

“…Hepatocellular carcinoma (HCC) is the most common primary hepatic cancer. Although it usually presents as a liver mass, rarely HCC can have an initial…”
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Recurrence of T-Cell Prolymphocytic Leukemia With a Rare Presentation as Diffuse Generalized Skin Lesion by Wasifuddin, Mustafa, Sabzposh, Hafsa, Sun, Lishi, Wu, Richard, Wang, Jen C.

“…T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm that originates from mature post-thymic T-cells. Cutaneous manifestations are a common…”
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Amyloidoma and Plasmacytoma Presented as a Solitary Lung Nodule in a Patient of Multiple Myeloma With AL-Amyloidosis: A Case Report and Review of Literature by Yadav, Ruchi, Sun, Lishi, Cheema, Akhtar, Yadav, Vivek, Wang, Jen Chin

“…Nodular amyloidoma in the lungs is a rare entity, also the occurrence of extramedullary plasmacytoma (EMP) in the lungs is rare. To have concomitant EMP and…”
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2413 Another Downside for Depression: A Case of SNRI-Induced Liver Injury by Odah, Tarek, Sun, Lishi, Treadwell, Thomas

“…INTRODUCTION: Antidepressants are one of the most prescribed medications in the United States with duloxetine being reported as one of the top fifty drug…”
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In Vitro Drug Studies of Inhibiting MDSC to Improve Efficacy of ICI (immune check point inhibitor) Therapy in Ph(-) myeloproliferative Neoplasm by Wang, Jen-Chin, Chen, Calvin Chi, Manvar, Kapilkumar, Sun, Lishi, Joseph, Gardith, Wong, Ching

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Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice by Hurez, Vincent, Dao, Vinh, Liu, Aijie, Pandeswara, Srilakshmi, Gelfond, Jonathan, Sun, Lishi, Bergman, Molly, Orihuela, Carlos J., Galvan, Veronica, Padrón, Álvaro, Drerup, Justin, Liu, Yang, Hasty, Paul, Sharp, Zelton Dave, Curiel, Tyler J.

“…Summary The mammalian (mechanistic) target of rapamycin (mTOR) regulates critical immune processes that remain incompletely defined. Interest in mTOR inhibitor…”
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IFNα Augments Clinical Efficacy of Regulatory T-cell Depletion with Denileukin Diftitox in Ovarian Cancer by Thibodeaux, Suzanne R, Barnett, Brian B, Pandeswara, Srilakshmi, Wall, Shawna R, Hurez, Vincent, Dao, Vinh, Sun, Lishi, Daniel, Benjamin J, Brumlik, Michael J, Drerup, Justin, Padrón, Álvaro, Whiteside, Teresa, Kryczek, Ilona, Zou, Weiping, Curiel, Tyler J

“…Immunotherapy treats some cancers, but not ovarian cancer. Regulatory T cells (Tregs) impede anti-ovarian cancer immunity but effective human Treg-directed…”
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Morphological and functional alterations of astrocytes responding to traumatic brain injury by Cheng, Xiaoyun, Wang, Jin, Sun, Xiao, Shao, Lishi, Guo, Zeyun, Li, Yang

“…Astrocytes, one of the most abundant and heterogeneous types of glial cell in the brain and spinal cord, are responsible for various essential functions in the…”
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Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL‐17 producing T cells by Sun, Lishi, Hurez, Vincent J., Thibodeaux, Suzanne R., Kious, Mark J., Liu, Aijie, Lin, Peiyi, Murthy, Kruthi, Pandeswara, Srilakshmi, Shin, Tahiro, Curiel, Tyler J.

“…Summary Regulatory T cells (Tregs) are specialized CD4+ T lymphocytes helping defend against autoimmunity and inflammation. Although age is associated with…”
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Abstract LB-259: Interferon-α enhances clinical benefits of regulatory T cell depletion in ovarian cancer through direct T cell effects and by inducing bystander IL-6 by Thibodeaux, Suzanne, Hurez, Vincent, Wall, Shawna, Pandeswara, Srilakshmi, Daniel, Benjamin, Liu, Aijie, Sun, Lishi, Wood, Leslie, Zou, Weiping, Curiel, Tyler

“…Abstract Tregs hinder anti-tumor immunity, and depleting them treats cancers effectively in mice. By contrast, Treg depletion in human trials has limited…”
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B7-H1 blockade plus regulatory T cell depletion improves clinical efficacy over either strategy alone in a melanoma model (P4268) by Curiel, Tyler, Murthy, Kruthi, Kious, Mark, Sun, Lishi, Zhang, Bin, Pandaswara, Srilakshmi, Hurez, Vincent

“…Abstract Denileukin diftitox (DD) is an FDA-approved conjugate of human IL-2 + diphtheria toxin. It depletes Tregs and improves clinical and immune outcomes,…”
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Oral rapamycin (eRapa) safely prevents carcinogen-induced dermal carcinogenesis through an interferon-γ-dependent mechanism (TUM7P.931) by Dao, Vinh, Hurez, Vincent, Pandeswara, Sri Lakshmi, Cardenas, Kim, Sun, Lishi, Liu, Aijie, Hasty, Paul, Sharp, Z. Dave, Curiel, Tyler

“…Abstract eRapa extends life in mice and cancer prevention could be a mechanism. Rapamycin inhibits mTOR, which has significant immune effects that are…”
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TMTP1, a Novel Tumor-homing Peptide, Specifically Targets Hematological Malignancies and Their Metastases by 肖敏 洪振亚 孙立石 吴颖 张娜 刘亚楠 罗丹枫 周剑峰 李春蕊

“…TMTP1, a 5-amino acid peptide NVVRQ, obtained by using the flagella peptide library screening in our previous studies, can be used for the labeling of…”
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Interferon-α augments the clinical efficacy of regulatory T cell depletion in ovarian cancer through direct and indirect T cell effects (VAC3P.941) by Thibodeaux, Suzanne, Hurez, Vincent, Wall, Shawna, Pandeswara, Sri Lakshmi, Sun, Lishi, Daniel, Benjamin, Liu, Aijie, Wood, Leslie, Zou, Weiping, Curiel, Tyler

“…Abstract Tregs blunt anti-tumor immunity, and their depletion effectively treats tumor in mouse cancer models. However, Treg depletion in human trials is only…”
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