Prognostic markers of colorectal cancer: an evaluation of DNA content, epidermal growth factor receptor, and Ki-67

Prognostic markers of colorectal cancer: an evaluation of DNA content, epidermal growth factor receptor, and Ki-67

Between January 1989 and August 1991, 62 patients undergoing resection for colorectal adenocarcinoma were assessed in a prospective fashion on the basis of various tumor characteristics that are thought to indicate prognosis. Parameters measured included epidermal growth factor receptor (EGFr) expre...

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Bibliographic Details
Published in:Journal of surgical oncology Vol. 51; no. 3; p. 147
Main Authors: Hemming, A W, Davis, N L, Kluftinger, A, Robinson, B, Quenville, N F, Liseman, B, LeRiche, J
Format: Journal Article
Language:English
Published: United States 01-11-1992
Subjects:
Adenocarcinoma - chemistry
Adenocarcinoma - pathology
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal
Colorectal Neoplasms - chemistry
Colorectal Neoplasms - pathology
DNA, Neoplasm - analysis
ErbB Receptors - analysis
Humans
Ki-67 Antigen
Middle Aged
Neoplasm Proteins - analysis
Neoplasm Staging
Nuclear Proteins - analysis
Ploidies
Prognosis
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Summary:Between January 1989 and August 1991, 62 patients undergoing resection for colorectal adenocarcinoma were assessed in a prospective fashion on the basis of various tumor characteristics that are thought to indicate prognosis. Parameters measured included epidermal growth factor receptor (EGFr) expression, a cell membrane receptor known to be overexpressed in a variety of tumors, Ki-67, a monoclonal antibody marker of cell proliferation, as well as flow cytometry and standard histologic examination. Statistical analysis included chi square with Yates correction when appropriate, Wilcoxon W, and multivariate logistic regression. EGFr positive tumors were associated with worse Dukes' stage (27% of EGFr negative tumors were Dukes' C or D vs. 58% of EGFr positive tumors, P = 0.03), as well as more aneuploid characteristics by flow cytometry (48% EGFr negative = aneuploid vs. 82% EGFr positive = aneuploid, P = 0.01). Lymphatic invasion was more frequent in EGFr positive tumors (P = 0.03). These factors proved to be independent of each other by multivariate analysis. Ki-67 did not correlate with any of the measured parameters and was of extremely limited use in the evaluation of the study population. Multivariate analysis indicated that aneuploid tumors were associated with worse Dukes' stage than diploid tumors. Histologic parameters such as lymphatic and vascular invasion as well as histologic grade are compared to the other parameters involved with prognosis.
ISSN:0022-4790
DOI:10.1002/jso.2930510304