Update on Brazilian essential oils with leishmanicidal activity

Update on Brazilian essential oils with leishmanicidal activity

Leishmaniasis are neglected diseases caused by protozoan parasites and have been mainly related to climate change, poverty, malnutrition, and the vulnerability of the host's immune system. The current drug therapy has limitations, motivating research for new active substances. This review descr...

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Bibliographic Details
Published in:Phytochemistry reviews Vol. 23; no. 1; pp. 105 - 123
Main Authors: Siqueira, Ingrid Borges, Oliveira, Yvanna Louise Di Christine, Jain, Sona, Silva, Audrey Rouse Soares Tavares, Nascimento, Luiz Fernando de Jesus, Lisboa, Márcio Luiz da Gama, Oliveira, Tiago Branquinho, Sousa, Damião Pergentino de, Barbosa, Ana Andrea Teixeira, Dolabella, Silvio Santana
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-02-2024
Springer Nature B.V
Subjects:
Amastigotes
Animal models
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
Climate change
Drug therapy
Essential oils
Flowers & plants
Immune system
Leishmania
Leishmaniasis
Life Sciences
Malnutrition
Oils & fats
Organic Chemistry
Parasites
Pharmacology
Plant extracts
Plant Genetics and Genomics
Plant Sciences
Plant species
Poverty
Promastigotes
Reviews
Vector-borne diseases
Brazil
Leishmaniasis
Brazilian biome
Terpenes
Phenolic compounds
Natural products
Antiprotozoal
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Summary:Leishmaniasis are neglected diseases caused by protozoan parasites and have been mainly related to climate change, poverty, malnutrition, and the vulnerability of the host's immune system. The current drug therapy has limitations, motivating research for new active substances. This review describes the leishmanicidal activity of essential oils, as well as their major compounds, extracted from native Brazilian plants. Forty-eight plant species, belonging to 16 families are included in this review, the most frequent being Piperaceae, Lauraceae, Asteraceae, Myrtaceae, and Verbenaceae. The studies included in this review show promising potential of plant species from different regions of Brazil against both amastigotes and promastigotes forms of Leishmania species, including Leishmania amazonensis, Leishmania chagasi, Leishmania braziliensis, Leishmania infantum, Leishmania donovani and Leishmania guyanensis . The essential oils from Croton cajucara Benth. (22.0 ng/mL), Tetradenia riparia (Hochst.) Codd. (30.0 ng/mL) and Aloysia gratissima (Gill et Hook) Tronc. (0.16 µg/mL), were found to be most active against the amastigote forms. In addition, the essential oils from C. cajucara (8.3 ng/mL); Protium hebetatum Daly (0.46 μg/mL), and T. riparia (0.8 μg/mL), were responsible for the lowest concentrations capable of inhibiting the growth of promastigote forms. However, there is a need for these results to be confirmed in animal models. In this way, advances can be made in the exploration of these essential oils and their constituents as potential therapeutic agents. Graphical abstract
ISSN:1568-7767
1572-980X
DOI:10.1007/s11101-023-09877-w