Search Results - "Lisa E. Humphrey"

UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer by Sane, Sanam, Srinivasan, Rekha, Potts, Rashaun A., Eikanger, Morgan, Zagirova, Diana, Freeling, Jessica, Reihe, Casey A., Antony, Ryan M., Gupta, Brij K., Lynch, Douglas, Bleeker, Jonathan, Turaihi, Hassan, Pillatzki, Angela, Zhou, Wei, Luo, Xu, Linnebacher, Michael, Agany, Diing, Zohim, Etienne Gnimpieba, Humphrey, Lisa E., Black, Adrian R., Rezvani, Khosrow

“…The mTORC2 pathway plays a critical role in promoting tumor progression in human colorectal cancer (CRC). The regulatory mechanisms for this signaling pathway…”
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Ron knockdown and Ron monoclonal antibody IMC-RON8 sensitize pancreatic cancer to histone deacetylase inhibitors (HDACi) by Zou, Yi, Howell, Gillian M, Humphrey, Lisa E, Wang, Jing, Brattain, Michael G

“…Recepteur d'origine nantais (Ron) is overexpressed in a panel of pancreatic cancer cells and tissue samples from pancreatic cancer patients. Ron can be…”
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Heterogeneity of Receptor Function in Colon Carcinoma Cells Determined by Cross-talk between Type I Insulin-like Growth Factor Receptor and Epidermal Growth Factor Receptor by HU, Yi Peter, PATIL, Sandip B, PANASIEWICZ, Michelle, WENHUI LI, HAUSER, Jennie, HUMPHREY, Lisa E, BRATTAIN, Michael G

“…This study identifies a novel cross-talk paradigm between the type I insulin-like growth factor receptor (IGF1R) and epidermal growth factor receptor (EGFR) in…”
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Reorganization of ErbB Family and Cell Survival Signaling after Knock-down of ErbB2 in Colon Cancer Cells by Hu, Yi Peter, Venkateswarlu, Srinivas, Sergina, Natalia, Howell, Gillian, Clair, Patricia St, Humphrey, Lisa E., Li, Wenhui, Hauser, Jennie, Zborowska, Elizabeth, Willson, James K.V., Brattain, Michael G.

“…The role of the ErbB family in supporting the malignant phenotype was characterized by stable transfection of a single chain antibody (ScFv5R) against ErbB2…”
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Selective Inhibition of Histone Deacetylases 1/2/6 in Combination with Gemcitabine: A Promising Combination for Pancreatic Cancer Therapy by Laschanzky, Richard S, Humphrey, Lisa E, Ma, Jihyun, Smith, Lynette M, Enke, Thomas J, Shukla, Surendra K, Dasgupta, Aneesha, Singh, Pankaj K, Howell, Gillian M, Brattain, Michael G, Ly, Quan P, Black, Adrian R, Black, Jennifer D

“…Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of <10% due in part to a lack of effective therapies. Pan-histone deacetylase (HDAC)…”
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Differences in Sensitivity of Biological Functions Mediated by Epidermal Growth Factor Receptor Activation with Respect to Endogenous and Exogenous Ligands by Sawhney, Rajinder S., Zhou, Guo-Hao K., Humphrey, Lisa E., Ghosh, Paramita, Kreisberg, Jeffrey I., Brattain, Michael G.

“…Despite constitutive expression of autocrine transforming growth factor-α (TGF-α) in growth factor-independent colon carcinoma cells, the epidermal growth…”
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Activation of the TGFα autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells by DEGENG WANG, PATIL, Sandip, WENHUI LI, HUMPHREY, Lisa E, BRATTAIN, Michael G, HOWELL, Gillian M

“…The inappropriate expression of TGFα in growth arrest contributes to malignant progression in human colon carcinoma cells. Early stage, non-progressed colon…”
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The role of transforming growth factor α in determining growth factor independence by AWWAD, Rana A, SERGINA, Natalia, HOWELL, Gillian M, HAISU YANG, ZIOBER, Barry, WILLSON, James K. V, ZBOROWSKA, Elizabeth, HUMPHREY, Lisa E, FAN, Robert, KO, Tien C, BRATTAIN, Michael G

“…Growth factor independence is a hallmark of malignancy that is attributed to the development of autocrine growth factor loops in cancer cells. However, growth…”
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The EGF/TGFα response element within the TGFα promoter consists of a multi-complex regulatory element by AWWAD, R, HUMPHREY, L. E, PERIYASAMY, B, SCOVELL, W. JR, WENHUI LI, COLEMAN, K, LYNCH, M, CARBONI, J, BRATTAIN, M. G, HOWELL, G. M

“…Autocrine TGFα is an important growth effector in the transformed phenotype. Growth stimulation of some colon cancer cells as well as other types of cancer…”
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Regulation of Transforming Growth Factor α Expression in a Growth Factor-Independent Cell Line by Howell, Gillian M., Humphrey, Lisa E., Ziober, Barry L., Awwad, Rana, Periyasamy, Basker, Koterba, Alan, Li, Wenhui, Willson, James K. V., Coleman, Kevin, Carboni, Joan, Lynch, Mark, Brattain, Michael G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Integrin α2 and Extracellular Signal-regulated Kinase Are Functionally Linked in Highly Malignant Autocrine Transforming Growth Factor-α-driven Colon Cancer Cells by Sawhney, Rajinder S., Sharma, Bhavya, Humphrey, Lisa E., Brattain, Michael G.

“…Recently, we have shown that autocrine transforming growth factor-α (TGF-α) controls the expression of integrin α2, cell adhesion to collagen IV and motility…”
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Heterogeneity of Receptor Function in Colon Carcinoma Cells Determined by Crosstalk between IGF1R and EGFR by Hu, Yi Peter, Patil, Sandip B., Panasiewicz, Michelle, Li, Wenhui, Hauser, Jennie, Humphrey, Lisa E., Brattain, Michael G.

“…This study identifies a novel crosstalk paradigm between the IGF1R and EGFR in colon cancer cells. IGF1R activation by ligand exposure in growth factor…”
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Activation of the TGF alpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells by Wang, D, Patil, S, Li, W, Humphrey, LE, Brattain, M G, Howell, G M

“…The inappropriate expression of TGF alpha in growth arrest contributes to malignant progression in human colon carcinoma cells. Early stage, non-progressed…”
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Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells by Sawhney, Rajinder S, Sharma, Bhavya, Humphrey, Lisa E, Brattain, Michael G

“…Recently, we have shown that autocrine transforming growth factor-alpha (TGF-alpha) controls the expression of integrin alpha2, cell adhesion to collagen IV…”
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Integrin α2 and Extracellular Signal-regulated Kinase Are Functionally Linked in Highly Malignant Autocrine Transforming Growth Factor-α-driven Colon Cancer Cells by Rajinder S. Sawhney, Bhavya Sharma, Lisa E. Humphrey, Michael G. Brattain

“…Recently, we have shown that autocrine transforming growth factor-α (TGF-α) controls the expression of integrin α 2 , cell adhesion to collagen IV and…”
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Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells by Wang, Degeng, Patil, Sandip, Li, Wenhui, Humphrey, Lisa E, Brattain, Michael G, Howell, Gillian M

“…The inappropriate expression of TGFalpha in growth arrest contributes to malignant progression in human colon carcinoma cells. Early stage, non-progressed…”
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Activation of the TGF[alpha] autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells by Wang, Degeng, Patil, Sandip, Li, Wenhui, Humphrey, Lisa E, Brattain, Michael G, Howell, Gillian M

“…The inappropriate expression of TGFalpha in growth arrest contributes to malignant progression in human colon carcinoma cells. Early stage, non-progressed…”
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Autocrine Transforming Growth Factor α Provides a Growth Advantage to Malignant Cells by Facilitating Re-entry into the Cell Cycle from Suboptimal Growth States by Jiang, Dianhua, Yang, Haisu, Willson, James K.V., Liang, Jiurong, Humphrey, Lisa E., Zborowska, Elizabeth, Wang, Degeng, Foster, Jason, Fan, Robert, Brattain, Michael G.

“…CBS human colon carcinoma cells are poorly tumorigenic in athymic nude mice, whereas FET colon carcinoma cells are non-tumorigenic. Both cell lines have well…”
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Autocrine TGFα expression in the regulation of initiation of human colon carcinoma growth by Wang, Degeng, Li, Wenhui, Jiang, Wen, Humphrey, Lisa E., Howell, Gillian M., Brattain, Michael G.

“…Previously, we reported that unaggressive, growth factor‐dependent FET human colon carcinoma cells downregulated their transforming growth factor alpha (TGFα)…”
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Autocrine TGF? expression in the regulation of initiation of human colon carcinoma growth by Wang, Degeng, Li, Wenhui, Jiang, Wen, Humphrey, Lisa E., Howell, Gillian M., Brattain, Michael G.

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