Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis

Objective. The safe and efficacious use of Pycnogenol® (French maritime pine bark extract) in other inflammatory diseases prompted this study of its antiinflammatory effects in patients with osteoarthritis (OA).The aim of the study was to evaluate whether Pycnogenol® reduces the symptoms of OA in a...

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Published in:	Phytotherapy research Vol. 22; no. 8; pp. 1087 - 1092
Main Authors:	Cisár, Peter, Jány, Richard, Waczulíková, Iweta, Sumegová, Katarína, Muchová, Jana, Vojtaššák, Jozef, Ďuraćková, Zdenka, Lisý, Miroslav, Rohdewald, Peter
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-08-2008 Wiley
Subjects:	Activities of Daily Living Adjuvants, Immunologic - therapeutic use Adult Aged Biological and medical sciences Double-Blind Method Female Flavonoids - therapeutic use General pharmacology Humans Male Medical sciences Middle Aged osteoarthritis Osteoarthritis, Knee - complications Osteoarthritis, Knee - drug therapy Osteoarthritis, Knee - physiopathology Pain - drug therapy Pain - etiology Pain - physiopathology Pain Measurement Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments pine bark extract Pinus - chemistry Plant Bark - chemistry Pycnogenol Quality of Life Severity of Illness Index Surveys and Questionnaires Treatment Outcome WOMAC Pycnogenol Pharmacognosy Diseases of the osteoarticular system Bark Extract Woody plant Pinus Medicinal plant Gymnospermae Plant origin pine bark extract Arthropathy WOMAC Coniferales Degenerative disease Spermatophyta Osteoarthritis
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Summary:	Objective. The safe and efficacious use of Pycnogenol® (French maritime pine bark extract) in other inflammatory diseases prompted this study of its antiinflammatory effects in patients with osteoarthritis (OA).The aim of the study was to evaluate whether Pycnogenol® reduces the symptoms of OA in a double-blind, placebo-controlled, randomly allocated trial with patients suffering from knee osteoarthritis stages I and II.Methods. 100 patients were treated for 3 months either by 150 mg Pycnogenol® per day at meals or by placebo. Patients had to report any change of use of previously prescribed antiinflammatory medication during the study period. Patients filled the Western Ontario and Mc Masters University (WOMAC) questionnaire for osteoarthritis every 2 weeks and evaluated weekly pain symptoms using a visual analogue scale for pain intensity.Results. Following treatment with Pycnogenol® patients reported an improvement of WOMAC index (p < 0.05), and a significant alleviation of pain by visual analogue scale (p < 0.04), the placebo had no effect. The use of analgesics diminished in the verum group but increased under the placebo. Treatment with Pycnogenol® was well tolerated.Conclusion. Results show that Pycnogenol® in patients with mild to moderate OA improves symptoms and is able to spare NSAIDs. Copyright © 2008 John Wiley & Sons, Ltd.
Bibliography:	http://dx.doi.org/10.1002/ptr.2461 ArticleID:PTR2461 Horphag Research Ltd; VEGA of Ministry of Education of Slovakia and Mind and Health, civil association - No. 1/2294/05; No. 1/1157/04; No. 1/3037/06 ark:/67375/WNG-MJW8FC95-L istex:DD12B519FAC80D675B8DEF3B1CF98CFA0B740DBC ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.2461