Search Results - "Lis, Annette"

Altered Ca2+ Homeostasis in Immune Cells during Aging: Role of Ion Channels by Zöphel, Dorina, Hof, Chantal, Lis, Annette

“…Aging is an unstoppable process and begins shortly after birth. Each cell of the organism is affected by the irreversible process, not only with equal density…”
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STIM2 drives Ca2+ oscillations through store‐operated Ca2+ entry caused by mild store depletion by Thiel, Markus, Lis, Annette, Penner, Reinhold

“…Key points Stromal cell‐interaction molecule (STIM) 2 senses Ca2+ levels in the endoplasmic reticulum and activates Ca2+ channels in the plasma membrane upon…”
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2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels by Peinelt, Christine, Lis, Annette, Beck, Andreas, Fleig, Andrea, Penner, Reinhold

“…2-Aminoethoxydiphenyl borate (2-APB) has emerged as a useful pharmacological tool in the study of store-operated Ca 2+ entry (SOCE). It has been shown to…”
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CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel by Vig, Monika, Beck, Andreas, Billingsley, James M., Lis, Annette, Parvez, Suhel, Peinelt, Christine, Koomoa, Dana L., Soboloff, Jonathan, Gill, Donald L., Fleig, Andrea, Kinet, Jean-Pierre, Penner, Reinhold

“…Receptor-mediated Ca2+ release from the endoplasmic reticulum (ER) is often followed by Ca2+ entry through Ca2+-release-activated Ca2+ (CRAC) channels in the…”
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TRPM7 is regulated by halides through its kinase domain by Yu, Haijie, Zhang, Zheng, Lis, Annette, Penner, Reinhold, Fleig, Andrea

“…Transient receptor potential melastatin 7 (TRPM7) is a divalent-selective cation channel fused to an atypical α-kinase. TRPM7 is a key regulator of cell growth…”
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Amplification of CRAC current by STIM1 and CRACM1 (Orai1) by Penner, Reinhold, Kinet, Jean-Pierre, Peinelt, Christine, Vig, Monika, Koomoa, Dana L, Beck, Andreas, Nadler, Monica J. S, Koblan-Huberson, Murielle, Lis, Annette, Fleig, Andrea

“…Depletion of intracellular calcium stores activates store-operated calcium entry across the plasma membrane in many cells. STIM1, the putative calcium sensor…”
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Ca2+-dependent regulation and binding of calmodulin to multiple sites of Transient Receptor Potential Melastatin 3 (TRPM3) ion channels by Przibilla, Julia, Dembla, Sandeep, Rizun, Oleksandr, Lis, Annette, Jung, Martin, Oberwinkler, Johannes, Beck, Andreas, Philipp, Stephan E.

“…[Display omitted] •TRPM3 channel activity is strongly reduced by increased cytoplasmic Ca2+ concentrations.•CaM binds to the full-length TRPM3 channel and to…”
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A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating by Lis, Annette, Zierler, Susanna, Peinelt, Christine, Fleig, Andrea, Penner, Reinhold

“…Store-operated Ca(2+) entry is controlled by the interaction of stromal interaction molecules (STIMs) acting as endoplasmic reticulum ER Ca(2+) sensors with…”
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Alternative Splicing of a Protein Domain Indispensable for Function of Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels by Frühwald, Julia, Camacho Londoño, Julia, Dembla, Sandeep, Mannebach, Stefanie, Lis, Annette, Drews, Anna, Wissenbach, Ulrich, Oberwinkler, Johannes, Philipp, Stephan E.

“…TRPM3 channels form ionotropic steroid receptors in the plasma membrane of pancreatic β and dorsal root ganglion cells and link steroid hormone signaling to…”
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Transient Receptor Potential Melastatin 1 (TRPM1) Is an Ion-conducting Plasma Membrane Channel Inhibited by Zinc Ions by Lambert, Sachar, Drews, Anna, Rizun, Oleksandr, Wagner, Thomas F.J., Lis, Annette, Mannebach, Stefanie, Plant, Sandra, Portz, Melanie, Meissner, Marcel, Philipp, Stephan E., Oberwinkler, Johannes

“…TRPM1 is the founding member of the melastatin subgroup of transient receptor potential (TRP) proteins, but it has not yet been firmly established that TRPM1…”
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Alternative Splicing Switches the Divalent Cation Selectivity of TRPM3 Channels by Oberwinkler, Johannes, Lis, Annette, Giehl, Klaus M., Flockerzi, Veit, Philipp, Stephan E.

“…TRPM3 is a poorly understood member of the large family of transient receptor potential (TRP) ion channels. Here we describe five novel splice variants of…”
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On the Connections between TRPM Channels and SOCE by Souza Bomfim, Guilherme H, Niemeyer, Barbara A, Lacruz, Rodrigo S, Lis, Annette

“…Plasma membrane protein channels provide a passageway for ions to access the intracellular milieu. Rapid entry of calcium ions into cells is controlled mostly…”
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Transcriptional regulation and processing increase the functional variability of TRPM channels by Lis, Annette, Wissenbach, Ulrich, Philipp, Stephan E

“…Mammalian TRP channels display heterogenous biophysical properties and are involved in a variety of signal transduction pathways. To carry out their diverse…”
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Elderly CD8 + T cells in the focus for immunotherapeutic approaches by Lis, Annette, Zöphel, Dorina

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Zytotoxische CD8+-T-Zellen im Alter: unterschätzte Killer? by Lis, Annette, Kaschek, Lea, Zöphel, Dorina

“…Abstract Aging leads to various alterations in immune cell functions. Here, we report our surprising findings that despite immunosenescence, CD8 + T cells’…”
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Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8+ T cells boost cancer cell elimination by Zöphel, Dorina, Angenendt, Adrian, Kaschek, Lea, Ravichandran, Keerthana, Hof, Chantal, Janku, Sandra, Hoth, Markus, Lis, Annette

“…A variety of intrinsic and extrinsic factors contribute to the altered efficiency of CTLs in elderly organisms. In particular, the efficacy of antiviral CD8+ T…”
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CRACM1, CRACM2, and CRACM3 Are Store-Operated Ca2+ Channels with Distinct Functional Properties by Lis, Annette, Peinelt, Christine, Beck, Andreas, Parvez, Suhel, Monteilh-Zoller, Mahealani, Fleig, Andrea, Penner, Reinhold

“…STIM1 in the endoplasmic reticulum and CRACM1 in the plasma membrane are essential molecular components for controlling the store-operated CRAC current [1–4]…”
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The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins by Suzuki, Sayuri, Lis, Annette, Schmitz, Carsten, Penner, Reinhold, Fleig, Andrea

“…The melastatin-related transient receptor potential member 7 (TRPM7) is a unique fusion protein with both ion channel function and enzymatic α-kinase activity…”
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STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment by Frisch, Janina, Angenendt, Adrian, Hoth, Markus, Prates Roma, Leticia, Lis, Annette

“…The tumor microenvironment (TME) is shaped by cancer and noncancerous cells, the extracellular matrix, soluble factors, and blood vessels. Interactions between…”
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Heterozygous OT‐I mice reveal that antigen‐specific CD8+ T cells shift from apoptotic to necrotic killers in the elderly by Zöphel, Dorina, Kaschek, Lea, Steiner, Romy, Janku, Sandra, Chang, Hsin‐Fang, Lis, Annette

“…Numerous alterations in CD8+ T cells contribute to impaired immune responses in elderly individuals. However, the discrimination between cell‐intrinsic…”
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