Search Results - "Lipsky, P"

Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity by Towne, Jennifer E., Renshaw, Blair R., Douangpanya, Jason, Lipsky, Brian P., Shen, Min, Gabel, Christopher A., Sims, John E.

“…IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2…”
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Chronic non-bacterial osteomyelitis in children by Girschick, H J, Raab, P, Surbaum, S, Trusen, A, Kirschner, S, Schneider, P, Papadopoulos, T, Müller-Hermelink, H K, Lipsky, P E

“…Background: Chronic recurrent multifocal osteomyelitis (CRMO) in children is a chronic non-suppurative inflammation involving multiple sites. Some children…”
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Clinical significance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus by Zhang, B, Zhang, X, Tang, F L, Zhu, L P, Liu, Y, Lipsky, P E

“…To investigate the expressions of Foxp3 and CD25 on CD4(+) T cells from patients with new-onset systemic lupus erythematosus (SLE) and assess their clinical…”
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Infliximab in active early rheumatoid arthritis by Breedveld, F C, Emery, P, Keystone, E, Patel, K, Furst, D E, Kalden, J R, St Clair, E W, Weisman, M, Smolen, J, Lipsky, P E, Maini, R N

“…Objective: To examine the impact of the combination of infliximab plus methotrexate (MTX) on the progression of structural damage in patients with early…”
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A critical review of clinical trials in systemic lupus erythematosus by Mahieu, M A, Strand, V, Simon, L S, Lipsky, P E, Ramsey-Goldman, R

“…One challenge in caring for patients with systemic lupus erythematosus (SLE) is a paucity of approved therapeutics for treatment of the diverse disease…”
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Rationale for interleukin-6 blockade in systemic lupus erythematosus by Tackey, E, Lipsky, P E, Illei, G G

“…Interleukin-6 (IL-6) is a pleiotropic cytokine with a wide range of biological activities that plays an important role in immune regulation and inflammation…”
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A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1 by Smith, Dirk E., Lipsky, Brian P., Russell, Chris, Ketchem, Randal R., Kirchner, Jacqueline, Hensley, Kelly, Huang, Yangyang, Friedman, Wilma J., Boissonneault, Vincent, Plante, Marie-Michèle, Rivest, Serge, Sims, John E.

“…Interleukin-1 (IL-1) has multiple functions in both the periphery and the central nervous system (CNS) and is regulated at many levels. We identified an…”
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The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33 by Palmer, Gaby, Lipsky, Brian P., Smithgall, Molly D., Meininger, David, Siu, Sophia, Talabot-Ayer, Dominique, Gabay, Cem, Smith, Dirk E.

“…Interleukin (IL)-33 (or IL-1F11) was recently identified as a ligand for the orphan IL-1 receptor family member T1/ST2 (ST2). IL-33 belongs to the IL-1…”
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Drug repositioning in SLE: crowd-sourcing, literature-mining and Big Data analysis by Grammer, A C, Ryals, M M, Heuer, S E, Robl, R D, Madamanchi, S, Davis, L S, Lauwerys, B, Catalina, M D, Lipsky, P E

“…Lupus patients are in need of modern drugs to treat specific manifestations of their disease effectively and safely. In the past half century, only one new…”
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Anti-inflammatory and Upper Gastrointestinal Effects of Celecoxib in Rheumatoid Arthritis: A Randomized Controlled Trial by Simon, Lee S, Weaver, Arthur L, Graham, David Y, Kivitz, Alan J, Lipsky, Peter E, Hubbard, Richard C, Isakson, Peter C, Verburg, Kenneth M, Yu, Shawn S, Zhao, William W, Geis, G. Steven

“…CONTEXT In vitro studies have shown that celecoxib inhibits cyclooxygenase 2 (COX-2) but not COX-1, suggesting that this drug may have anti-inflammatory and…”
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Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis by Lipsky, Peter E, van der Heijde, Desiree M.F.M, St. Clair, E. William, Furst, Daniel E, Breedveld, Ferdinand C, Kalden, Joachim R, Smolen, Josef S, Weisman, Michael, Emery, Paul, Feldmann, Marc, Harriman, Gregory R, Maini, Ravinder N

“…Tumor necrosis factor α (TNF-α) has a central role in the pathogenesis of rheumatoid arthritis, 1 – 3 as demonstrated by the clinical benefit of…”
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Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus by Sawalha, A H, Kaufman, K M, Kelly, J A, Adler, A J, Aberle, T, Kilpatrick, J, Wakeland, E K, Li, Q-Z, Wandstrat, A E, Karp, D R, James, J A, Merrill, J T, Lipsky, P, Harley, J B

“…The aetiology of systemic lupus erythematosus (SLE) is incompletely understood. Both genetic and environmental factors are implicated in the pathogenesis of…”
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Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus by Odendahl, Marcus, Jacobi, Annett, Hansen, Arne, Feist, Eugen, Hiepe, Falk, Burmester, Gerd R, Lipsky, Peter E, Radbruch, Andreas, Dorner, Thomas

“…In patients with active systemic lupus erythematosus (SLE), a marked B lymphocytopenia was identified that affected CD19(+)/CD27(-) naive B cells more than…”
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Fluorescence resonance energy transfer from cyan to yellow fluorescent protein detected by acceptor photobleaching using confocal microscopy and a single laser by Karpova, T. S., Baumann, C. T., He, L., Wu, X., Grammer, A., Lipsky, P., Hager, G. L., McNally, J. G.

“…Summary One manifestation of fluorescence resonance energy transfer (FRET) is an increase in donor fluorescence after photobleaching the acceptor. Published…”
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Association between baseline radiographic damage and improvement in physical function after treatment of patients with rheumatoid arthritis by Breedveld, F C, Han, C, Bala, M, van der Heijde, D, Baker, D, Kavanaugh, A F, Maini, R N, Lipsky, P E

“…Objectives: To identify factors associated with poor physical function in rheumatoid arthritis and to assess whether baseline joint damage has an impact on…”
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Cyclooxygenase in biology and disease by DuBois, Raymond N., Abramson, Steven B., Crofford, Leslie, Gupta, Rajnish A., Simon, Lee S., Putte, Leo B. A., Lipsky, Peter E.

“…ABSTRACT Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to prostaglandins was first identified over 20 years ago. Drugs,…”
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Stromal Cell-Derived Factor-1-CXC Chemokine Receptor 4 Interactions Play a Central Role in CD4+ T Cell Accumulation in Rheumatoid Arthritis Synovium by Nanki, Toshihiro, Hayashida, Kenji, El-Gabalawy, Hani S, Suson, Sharon, Shi, Kenrin, Girschick, Hermann J, Yavuz, Sule, Lipsky, Peter E

“…Rheumatoid arthritis (RA) is characterized by the accumulation of CD4(+) memory T cells in the inflamed synovium. To address the mechanism, we analyzed…”
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Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity by Lipsky, Peter E

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The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F by Tao, X, Lipsky, P E

“…Various preparations of Tripterygium wilfordii Hook F (TwHF) have been used in the treatment of a number of autoimmune and inflammatory diseases since the…”
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Lymphoid Chemokine B Cell-Attracting Chemokine-1 (CXCL13) Is Expressed in Germinal Center of Ectopic Lymphoid Follicles Within the Synovium of Chronic Arthritis Patients by Shi, Kenrin, Hayashida, Kenji, Kaneko, Motoharu, Hashimoto, Jun, Tomita, Tetsuya, Lipsky, Peter E, Yoshikawa, Hideki, Ochi, Takahiro

“…A unique feature in inflammatory tissue of rheumatoid arthritis (RA) is the formation of ectopic lymphoid aggregates with germinal center (GC)-like structures…”
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