Search Results - "Lippok, Barbara E."

Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10 by Korn, Patricia, Classen, Arno, Murthy, Sudarshan, Guareschi, Riccardo, Maksimainen, Mirko M., Lippok, Barbara E., Galera‐Prat, Albert, Sowa, Sven T., Voigt, Catharina, Rossetti, Giulia, Lehtiö, Lari, Bolm, Carsten, Lüscher, Bernhard

“…Intracellular ADP‐ribosyltransferases catalyze mono‐ and poly‐ADP‐ribosylation and affect a broad range of biological processes. The…”
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Characterization of the Signaling Capacities of the Novel gp130-like Cytokine Receptor by Dreuw, Alexandra, Radtke, Simone, Pflanz, Stefan, Lippok, Barbara E, Heinrich, Peter C, Hermanns, Heike M

“…The gp130-like receptor (GPL) is a recently cloned member of the family of type I cytokine receptors. The name reflects its close relationship to gp130, the…”
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Box 2 Region of the Oncostatin M Receptor Determines Specificity for Recruitment of Janus Kinases and STAT5 Activation by Hintzen, Christoph, Evers, Christina, Lippok, Barbara E., Volkmer, Rudolf, Heinrich, Peter C., Radtke, Simone, Hermanns, Heike M.

“…Human and murine oncostatin M (OSM) induce their bioactivities through a heterodimeric receptor complex consisting of gp130 and the OSM receptor (OSMR), which…”
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[1,2,4]Triazolo[3,4‑b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes by Murthy, Sudarshan, Nizi, Maria Giulia, Maksimainen, Mirko M., Massari, Serena, Alaviuhkola, Juho, Lippok, Barbara E., Vagaggini, Chiara, Sowa, Sven T., Galera-Prat, Albert, Ashok, Yashwanth, Venkannagari, Harikanth, Prunskaite-Hyyryläinen, Renata, Dreassi, Elena, Lüscher, Bernhard, Korn, Patricia, Tabarrini, Oriana, Lehtiö, Lari

“…We report [1,2,4]­triazolo­[3,4-b]­benzothiazole (TBT) as a new inhibitor scaffold, which competes with nicotinamide in the binding pocket of human poly- and…”
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Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15 by Nizi, Maria Giulia, Maksimainen, Mirko M., Murthy, Sudarshan, Massari, Serena, Alaviuhkola, Juho, Lippok, Barbara E., Sowa, Sven T., Galera-Prat, Albert, Prunskaite-Hyyryläinen, Renata, Lüscher, Bernhard, Korn, Patricia, Lehtiö, Lari, Tabarrini, Oriana

“…While human poly-ADP-ribose chain generating poly-ARTs, PARP1 and 2 and TNKS1 and 2, have been widely characterized, less is known on the pathophysiological…”
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Caspase‐dependent cleavage of the mono‐ADP‐ribosyltransferase ARTD10 interferes with its pro‐apoptotic function by Herzog, Nicolas, Hartkamp, Jörg D. H., Verheugd, Patricia, Treude, Fabian, Forst, Alexandra H., Feijs, Karla L. H., Lippok, Barbara E., Kremmer, Elisabeth, Kleine, Henning, Lüscher, Bernhard

“…ADP‐ribosylation is a post‐translational modification that regulates various physiological processes, including DNA damage repair, gene transcription and…”
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Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation by Radtke, Simone, Wüller, Stefan, Yang, Xiang-ping, Lippok, Barbara E, Mütze, Barbara, Mais, Christine, de Leur, Hildegard Schmitz-Van, Bode, Johannes G, Gaestel, Matthias, Heinrich, Peter C, Behrmann, Iris, Schaper, Fred, Hermanns, Heike M

“…The inflammatory response involves a complex interplay of different cytokines which act in an auto- or paracrine manner to induce the so-called acute phase…”
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Oncostatin M-induced activation of stress-activated MAP kinases depends on tyrosine 861 in the OSM receptor and requires Jak1 but not Src kinases by Böing, Irene, Stross, Claudia, Radtke, Simone, Lippok, Barbara E., Heinrich, Peter C., Hermanns, Heike M.

“…We have investigated the molecular mechanisms involved in the activation process of the stress-activated protein kinases (SAPK) p38 and JNK in response to the…”
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Cover Feature: Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10 (ChemistryOpen 10/2021) by Korn, Patricia, Classen, Arno, Murthy, Sudarshan, Guareschi, Riccardo, Maksimainen, Mirko M., Lippok, Barbara E., Galera‐Prat, Albert, Sowa, Sven T., Voigt, Catharina, Rossetti, Giulia, Lehtiö, Lari, Bolm, Carsten, Lüscher, Bernhard

“…The Cover Feature shows the functions of protein coding PARP10 gene in multiple processes, including DNA repair, signaling and innate immunity. Moreover, the…”
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Caspase‐dependent cleavage of the mono‐ ADP ‐ribosyltransferase ARTD 10 interferes with its pro‐apoptotic function by Herzog, Nicolas, Hartkamp, Jörg D. H., Verheugd, Patricia, Treude, Fabian, Forst, Alexandra H., Feijs, Karla L. H., Lippok, Barbara E., Kremmer, Elisabeth, Kleine, Henning, Lüscher, Bernhard

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