Search Results - "Lipnick, Scott L."

Temporal bias in case-control design: preventing reliable predictions of the future by Yuan, William, Beaulieu-Jones, Brett K., Yu, Kun-Hsing, Lipnick, Scott L., Palmer, Nathan, Loscalzo, Joseph, Cai, Tianxi, Kohane, Isaac S.

“…One of the primary tools that researchers use to predict risk is the case-control study. We identify a flaw, temporal bias, that is specific to and uniquely…”
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Systemic nature of spinal muscular atrophy revealed by studying insurance claims by Lipnick, Scott L, Agniel, Denis M, Aggarwal, Rahul, Makhortova, Nina R, Finlayson, Samuel G, Brocato, Alexandra, Palmer, Nathan, Darras, Basil T, Kohane, Isaac, Rubin, Lee L

“…We investigated the presence of non-neuromuscular phenotypes in patients affected by Spinal Muscular Atrophy (SMA), a disorder caused by a mutation in the…”
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Accelerating diagnosis of Parkinson's disease through risk prediction by Yuan, William, Beaulieu-Jones, Brett, Krolewski, Richard, Palmer, Nathan, Veyrat-Follet, Christine, Frau, Francesca, Cohen, Caroline, Bozzi, Sylvie, Cogswell, Meaghan, Kumar, Dinesh, Coulouvrat, Catherine, Leroy, Bruno, Fischer, Tanya Z, Sardi, S Pablo, Chandross, Karen J, Rubin, Lee L, Wills, Anne-Marie, Kohane, Isaac, Lipnick, Scott L

“…Characterization of prediagnostic Parkinson's Disease (PD) and early prediction of subsequent development are critical for preventive interventions, risk…”
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Disease progression strikingly differs in research and real-world Parkinson’s populations by Beaulieu-Jones, Brett K., Frau, Francesca, Bozzi, Sylvie, Chandross, Karen J., Peterschmitt, M. Judith, Cohen, Caroline, Coulovrat, Catherine, Kumar, Dinesh, Kruger, Mark J., Lipnick, Scott L., Fitzsimmons, Lane, Kohane, Isaac S., Scherzer, Clemens R.

“…Characterization of Parkinson’s disease (PD) progression using real-world evidence could guide clinical trial design and identify subpopulations. Efforts to…”
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Molecular Mechanisms of Late Normal Tissue Injury by Brush, James, MS, Lipnick, Scott L., BS, Phillips, Tiffany, MS, Sitko, John, BS, McDonald, J. Tyson, BSE, McBride, William H., D.Sc

“…Irradiation perturbs the homeostatic network linking parenchymal, mesenchymal, and vascular cells within tissues. Normal communication between cells through…”
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Single-cell transcriptomic profiling of the aging mouse brain by Ximerakis, Methodios, Lipnick, Scott L., Innes, Brendan T., Simmons, Sean K., Adiconis, Xian, Dionne, Danielle, Mayweather, Brittany A., Nguyen, Lan, Niziolek, Zachary, Ozek, Ceren, Butty, Vincent L., Isserlin, Ruth, Buchanan, Sean M., Levine, Stuart S., Regev, Aviv, Bader, Gary D., Levin, Joshua Z., Rubin, Lee L.

“…The mammalian brain is complex, with multiple cell types performing a variety of diverse functions, but exactly how each cell type is affected in aging remains…”
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Structure and Magnetic Fields in the Precessing Jet System SS 433. I. Multifrequency Imaging from 1998 by Roberts, David H, Wardle, John F. C, Lipnick, Scott L, Selesnick, Philip L, Slutsky, Simon

“…The Very Large Array has been used at five frequencies to study the structure and linear polarization of SS 433 on scales as small as [image]. Each jet…”
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Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types by Ximerakis, Methodios, Holton, Kristina M, Giadone, Richard M, Ozek, Ceren, Saxena, Monika, Santiago, Samara, Adiconis, Xian, Dionne, Danielle, Nguyen, Lan, Shah, Kavya M, Goldstein, Jill M, Gasperini, Caterina, Gampierakis, Ioannis A, Lipnick, Scott L, Simmons, Sean K, Buchanan, Sean M, Wagers, Amy J, Regev, Aviv, Levin, Joshua Z, Rubin, Lee L

“…Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent…”
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Cross-modal representation alignment of molecular structure and perturbation-induced transcriptional profiles by Finlayson, Samuel G, McDermott, Matthew B A, Pickering, Alex V, Lipnick, Scott L, Kohane, Isaac S

“…Modeling the relationship between chemical structure and molecular activity is a key goal in drug development. Many benchmark tasks have been proposed for…”
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Applying Deep Neural Network Analysis to High-Content Image-Based Assays by Yang, Samuel J, Lipnick, Scott L, Makhortova, Nina R, Venugopalan, Subhashini, Fan, Minjie, Armstrong, Zan, Schlaeger, Thorsten M, Deng, Liyong, Chung, Wendy K, O'Callaghan, Liadan, Geraschenko, Anton, Whye, Dosh, Berndl, Marc, Hazard, Jon, Williams, Brian, Narayanaswamy, Arunachalam, Ando, D Michael, Nelson, Philip, Rubin, Lee L

“…The etiological underpinnings of many CNS disorders are not well understood. This is likely due to the fact that individual diseases aggregate numerous…”
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Implementation and Evaluation of Slice and Volume Localized Echo-planar Correlated Spectroscopic Imaging (EP-COSI) Sequences: Studies in Phantoms, the Brain and the Calf by Lipnick, Scott L

“…In this dissertation the majority of the effort was spent developing the Echo-Planar Correlation Spectroscopic Imaging (EP-COSI) pulse sequence, which is the…”
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Cross-modal representation alignment of molecular structure and perturbation-induced transcriptional profiles by Finlayson, Samuel G, McDermott, Matthew B. A, Pickering, Alex V, Lipnick, Scott L, Kohane, Isaac S

“…Modeling the relationship between chemical structure and molecular activity is a key goal in drug development. Many benchmark tasks have been proposed for…”
Get full text

Implementation and Evaluation of Slice and Volume Localized Echo-planar Correlated Spectroscopic Imaging (EP-COSI) Sequences: Studies in Phantoms, the Brain and the Calf by Lipnick, Scott L

“…In this dissertation the majority of the effort was spent developing the Echo-Planar Correlation Spectroscopic Imaging (EP-COSI) pulse sequence, which is the…”
Get full text

Structure and Magnetic Fields in the Precessing Jet System SS 433 I. Multi-Frequency Imaging from 1998 by Roberts, David H, Wardle, John F. C, Lipnick, Scott L, Selesnick, Philip L, Slutsky, Simon

“…The Very Large Array has been used at five frequencies to study the structure and linear polarization of SS433 on scales as small as ~0.1" ~ 500 AU. Each jet…”
Get full text