Search Results - "Lipkowitz, Stan"

WW Domain HECT E3s Target Cbl RING Finger E3s for Proteasomal Degradation by Magnifico, Alessandra, Ettenberg, Seth, Yang, Cuihong, Mariano, Jennifer, Tiwari, Swati, Fang, Shengyun, Lipkowitz, Stan, Weissman, Allan M.

“…Cbl proteins have RING finger-dependent ubiquitin ligase (E3) activity that is essential for down-regulation of tyrosine kinases. Here we establish that two WW…”
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A Conserved DpYR Motif in the Juxtamembrane Domain of the Met Receptor Family Forms an Atypical c-Cbl/Cbl-b Tyrosine Kinase Binding Domain Binding Site Required for Suppression of Oncogenic Activation by Peschard, Pascal, Ishiyama, Noboru, Lin, Tong, Lipkowitz, Stan, Park, Morag

“…The activation and phosphorylation of Met, the receptor tyrosine kinase (RTK) for hepatocyte growth factor, initiates the recruitment of multiple signaling…”
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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b by Penninger, Josef M, Bachmaier, Kurt, Krawczyk, Connie, Kozieradzki, Ivona, Kong, Young-Yun, Sasaki, Takehiko, Oliveira-dos-Santos, Antonio, Mariathasan, Sanjeev, Bouchard, Dennis, Wakeham, Andrew, Itie, Annick, Le, Jenny, Ohashi, Pamela S, Sarosi, Ildiko, Nishina, Hiroshi, Lipkowitz, Stan

“…The signalling thresholds of antigen receptors and co-stimulatory receptors determine immunity or tolerance to self molecules. Changes in co-stimulatory…”
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Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl) by Zeng, Shan, Xu, Zhiheng, Lipkowitz, Stan, Longley, Jack B.

“…Activation of the KIT receptor tyrosine kinase contributes to the pathogenesis of several human diseases, but the mechanisms regulating KIT signaling have not…”
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Evaluation of Biologic End Points and Pharmacokinetics in Patients With Metastatic Breast Cancer After Treatment With Erlotinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor by TAN, Antoinette R, XIAOWEI YANG, BACHARACH, Stephen L, WHATLEY, Millie, CARRASQUILLO, Jorge A, BRAHIM, Jaime S, ETTENBERG, Seth A, LIPKOWITZ, Stan, SWAIN, Sandra M, HEWITT, Stephen M, BERMAN, Arlene, LEPPER, Erin R, SPARREBOOM, Alex, PARR, Allyson L, FIGG, William D, CHOW, Catherine, STEINBERG, Seth M

“…To evaluate changes in epidermal growth factor receptor (EGFR) phosphorylation and its downstream signaling in tumor and surrogate tissue biopsies in patients…”
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Synergistic Induction of Apoptosis by the Combination of TRAIL and Chemotherapy in Chemoresistant Ovarian Cancer Cells by Cuello, Mauricio, Ettenberg, Seth A., Nau, Marion M., Lipkowitz, Stan

“…Objectives. The aim of this study was to investigate whether TNF-related apoptosis-inducing ligand (TRAIL) alone or in combination with chemotherapy could…”
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Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b by DAVIES, Gareth C, ETTENBERG, Seth A, COATS, Ashley O, MUSSANTE, Mark, RAVICHANDRAN, Sarangan, COLLINS, Jack, NAU, Marion M, LIPKOWITZ, Stan

“…Cbl proteins are ubiquitin protein ligases, which ubiquitinate activated tyrosine kinases and target them for degradation. Both c-Cbl and Cbl-b have an…”
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Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options by So, Jae Young, Ohm, Joyce, Lipkowitz, Stan, Yang, Li

“…Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intra-tumoral heterogeneity, and frequently develops resistance to…”
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Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling Complex by Ettenberg, Seth A., Magnifico, Alessandra, Cuello, Mauricio, Nau, Marion M., Rubinstein, Yaffa R., Yarden, Yosef, Weissman, Allan M., Lipkowitz, Stan

“…Cbl proteins function as ubiquitin protein ligases for the activated epidermal growth factor receptor and, thus, negatively regulate its activity. Here we show…”
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Randomized Comparison of Group Versus Individual Genetic Education and Counseling for Familial Breast and/or Ovarian Cancer by CALZONE, Kathleen A, PRINDIVILLE, Sheila A, KLEIN, Pamela, KIRSCH, Ilan R, JOURKIV, Oxana, JENKINS, Jean, DECARVALHO, Maria, WALLERSTEDT, Dawn B, LIEWEHR, David J, STEINBERG, Seth M, SOBALLE, Peter W, LIPKOWITZ, Stan

“…An efficient approach to education and counseling before BRCA1 and BRCA2 mutation testing is necessary for effective utilization of testing in the community…”
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Comparative genomic organization of the cbl genes by Nau, Marion M., Lipkowitz, Stan

“…The genomic organization of cbl genes from a variety of mammalian and non-mammalian species was determined by a combination of cloning and database searches…”
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cbl-3 : a new mammalian cbl family protein by KEANE, M. M, ETTENBERG, S. A, NAU, M. M, BANERJEE, P, CUELLO, M, PENNINGER, J, LIPKOWITZ, S

“…We have cloned a new human gene, cbl-3, which encodes a protein with marked homology to the cbl family of proteins. The predicted protein encoded by this gene…”
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cbl-b inhibits epidermal growth factor receptor signaling by ETTENBERG, S. A, KEANE, M. M, NAU, M. M, FRANKEL, M, WANG, L.-M, PIERCE, J. H, LIPKOWITZ, S

“…The role of cbl-b in signaling by the epidermal growth factor receptor (EGFR) was studied and compared with c-cbl. We demonstrate in vivo, that cbl-b, like…”
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Cbl-3-Deficient Mice Exhibit Normal Epithelial Development by Griffiths, Emily K., Sanchez, Otto, Mill, Pleasantine, Krawczyk, Connie, Hojilla, Carlo V., Rubin, Evelyn, Nau, Marion M., Khokha, Rama, Lipkowitz, Stan, Hui, Chi-chung, Penninger, Josef M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding by CHEN, W.-D, OTTERSON, G. A, LIPKOWITZ, S, KHLEIF, S. N, COXON, A. B, KAYE, F. J

“…Dephosphorylation of the RB protein has been reported to be associated with apoptosis. In contrast, we show that treatment of HL60 cells with etoposide or…”
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Abstract 2539: Tumor necrosis factor related apoptosis inducing ligand (TRAIL) induces cytokine release via the alternative NFKB2 pathway in triple negative breast cancer cells (TNBC) and modulates neutrophil chemotaxis by Kundu, Manjari, Greer, Yoshimi Endo, Ridnour, Lisa A., Wink, David A., Lipkowitz, Stan

“…Abstract TRAIL induces apoptosis in many preclinical cancer models including breast cancers and has been extensively studied as a potential cancer therapeutic…”
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ENLIGHT: Pancancer response prediction to targeted and immunotherapies via tumor transcriptomics by Aharonov, Ranit, Dinstag, Gal, Shulman, Eldad, Elis, Efrat, Ben-Zvi, Doreen, Tirosh, Omer, Hoang, Danh-Tai, SInha, Sanju, Apolo, Andrea B., Dahut, William L., Lipkowitz, Stan, Berger, Raanan, Kurzrock, Razelle, Papanicolau-Sengos, Antonios, Karzai, Fatima, Rajagopal, Padma Sheila, Gilbert, Mark R., Aldape, Kenneth D., Beker, Tuvik, Ruppin, Eytan

“…e13556 Background: Precision oncology is gradually advancing into mainstream clinical practice. Despite the significant recent growth in the number of approved…”
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Abstract 347: Tumor necrosis factor related apoptosis inducing ligand (TRAIL)-induced cytokine production in TNBC promotes neutrophil chemotaxis and immune suppression by Kundu, Manjari, Greer, Yoshimi Endo, Ridnour, Lisa Ann, Wink, David A, Ng, Yeap S., Weigert, Roberto, Lipkowitz, Stan

“…Abstract Background: TRAIL induces apoptosis in many preclinical cancer models including breast cancers and has been extensively studied as a potential cancer…”
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Phase I with expansion cohorts in a study of NEO-201 in adults with chemo-resistant solid tumors by Morelli, M. Pia, Houston, Nicole D., Lipkowitz, Stan, Lee, Jung-min, Zimmer, Alexandra Dos Santos, Zia, Farah Z., Trewhitt, Kathrine, Nichols, Erin, Pavelova, Mira, Hewitt, Stephen M., Fantini, Massimo, Arlen, Philip M., Tsang, Kwong Y., Annunziata, Christina M.

“…Abstract only 129 Background: NEO-201 is a humanized IgG1 monoclonal antibody (mAb) generated against tumor-associated antigens (TAA) from colorectal cancer…”
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Effect of the combination of tumor necrosis factor related apoptosis inducing ligand (TRAIL) and the cyclin dependent kinase inhibitor dinaciclib on HPV+ cervical cancer cells by Kotlyar, David, Greer, Yoshimi, Voeller, Donna, Hernandez, Lidia, Annunziata, Christina M., Lipkowitz, Stan

“…Abstract only…”
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