Search Results - "Lipkind, G M"

Mechanism of local anesthetic drug action on voltage-gated sodium channels by Fozzard, H A, Lee, P J, Lipkind, G M

“…Local anesthetic drugs interfere with excitation and conduction by action potentials in the nervous system and in the heart by blockade of the voltage-gated Na…”
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Isoform-dependent interaction of voltage-gated sodium channels with protons by Khan, A., Kyle, J. W., Hanck, D. A., Lipkind, G. M., Fozzard, H. A.

“…Protons are potent physiological modifiers of voltage-gated Na + channels, shifting the voltage range of channel gating and reducing current magnitude (p K a…”
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Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families by VELHO, G, BLANCHE, H, MAROTTA, D, PILKIS, S. J, LIPKIND, G. M, BELL, G. I, FROGUEL, P, VAXILLAIRE, M, BELLANNE-CHANTELOT, C, PARDINI, V. C, TIMSIT, J, PASSA, P, DESCHAMPS, I, ROBERT, J.-J, WEBER, I. T

“…Mutations in glucokinase are associated with defects in insulin secretion and hepatic glycogen synthesis resulting in mild chronic hyperglycaemia, impaired…”
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A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel by Lipkind, G.M., Fozzard, H.A.

“…Biophysical evidence has placed the binding site for the naturally occurring marine toxins tetrodotoxin (TTX) and saxitoxin (STX) in the external mouth of the…”
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KcsA Crystal Structure as Framework for a Molecular Model of the Na+ Channel Pore by Lipkind, Gregory M, Fozzard, Harry A

“…The crystal structure of the pore-forming part of the KcsA bacterial K+-selective channel suggests a possible motif for related voltage-gated channels. We…”
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A model of scorpion toxin binding to voltage-gated K+ channels by Lipkind, G M, Fozzard, H A

“…Mutational studies have identified part of the S5-S6 loop of voltage-dependent K+ channels (P region) responsible for tetraethylammonium (TEA) block and…”
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A Structural Motif for the Voltage-Gated Potassium Channel Pore by Lipkind, Gregory M., Hanck, Dorothy A., Fozzard, Harry A.

“…Mutation studies have identified a region of the S5-S6 loop of voltage-gated K+channels (P region) responsible for tetraethylammonium (TEA) block and…”
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Modeling of the Outer Vestibule and Selectivity Filter of the L-Type Ca2+ Channel by Lipkind, Gregory M, Fozzard, Harry A

“…Using the KcsA bacterial K+ channel crystal structure [Doyle, D. A., et al. (1998) Science 280, 69−74] and the model of the outer vestibule of the Na+ channel…”
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Differences in Saxitoxin and Tetrodotoxin Binding Revealed by Mutagenesis of the Na + Channel Outer Vestibule by Penzotti, Jennifer L., Fozzard, Harry A., Lipkind, Gregory M., Dudley, Samuel C.

“…The marine guanidinium toxins, saxitoxin (STX) and tetrodotoxin (TTX), have played crucial roles in the study of voltage-gated Na + channels. Because they have…”
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N.m.r. and conformational analysis of some 2,3-disubstituted methyl alpha-L-rhamnopyranosides by Kochetkov, N K, Lipkind, G M, Shashkov, A S, Nifant'ev, N E

“…Conformational studies of the branched trisaccharide glycosides X-(1---2)[Y-(1---3)]-alpha-L-Rha-OMe (where X and Y are residues of alpha-L-, beta-L-,…”
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Predominant Interactions between μ-Conotoxin Arg-13 and the Skeletal Muscle Na+ Channel Localized by Mutant Cycle Analysis by Chang, Nancy S, French, Robert J, Lipkind, Gregory M, Fozzard, Harry A, Dudley, Samuel

“…High-affinity μ-conotoxin block of skeletal muscle Na+ channels depends on an arginine at position 13 (Arg-13). To understand both the mechanism of toxin…”
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Mutational Analysis of Predicted Interactions between the Catalytic and P Domains of Prohormone Convertase 3 (PC3/PC1) by Ueda, Kazuya, Lipkind, Gregory M., Zhou, An, Zhu, Xiaorong, Kuznetsov, Andrey, Philipson, Louis, Gardner, Paul, Zhang, Chunling, Steiner, Donald F.

“…The subtilisin-like prohormone convertases (PCs) contain an essential downstream domain (P domain), which has been predicted to have a β-barrel structure that…”
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The tetrodotoxin binding site is within the outer vestibule of the sodium channel by Fozzard, Harry A, Lipkind, Gregory M

“…Tetrodotoxin and saxitoxin are small, compact asymmetrical marine toxins that block voltage-gated Na channels with high affinity and specificity. They enter…”
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A Model for the Structure of the P Domains in the Subtilisin-Like Prohormone Convertases by Lipkind, Gregory M., Zhou, An, Steiner, Donald F.

“…The proprotein convertases are a family of at least seven calcium-dependent endoproteases that process a wide variety of precursor proteins in the secretory…”
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Nuclear Overhauser effects and conformations of branched trisaccharide methyl beta-glycosides that contain a 3,4-disubstituted galactose residue by Lipkind, G M, Shashkov, A S, Nechaev, O A, Torgov, V I, Shibaev, V N, Kochetkov, N K

“…N.O.e. data after pre-irradiation of the anomeric protons and the 3JC,H values associated with the glycosidic linkages for a series of methyl beta-glycosides…”
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Nuclear Overhauser effects and conformations of branched trisaccharide methyl beta-glycosides that contain a 2,3-disubstituted galactose residue by Lipkind, G M, Shashkov, A S, Nechaev, O A, Torgov, V I, Shibaev, V N, Kochetkov, N K

“…On the basis of the n.O.e. data and theoretical calculations, it was found that less than 90% of one conformer was present in aqueous solution for each of a…”
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Theoretical determination of thermodynamic parameters for incorporation of amino acid residues in alpha-helix of poly-L-alanine. Calculation of parameters for leucine and aspartic acid by Lipkind, G M, Popov, E M

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Synthesis of di-O-glycosyl derivatives of methyl alpha-L-rhamnopyranoside by Nifant'ev, N E, Lipkind, G M, Shashkov, A S, Kochetkov, N K

“…The syntheses are described of 2,3-di-O-glycosyl derivatives (1-12) of methyl alpha-L-rhamnopyranoside where the glycosyl moieties are variously…”
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Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels by Lipkind, Gregory M, Fozzard, Harry A

“…Voltage-gated sodium (Na+) channels are targets for local anesthetic (LA) drugs that bind in the inner pore of the channel with affinities related to the…”
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Theoretical conformational analysis of methylamides of N-acetyl-L-serine and N-acetyl-L-asparagine by Lipkind, G M, Arkhipova, S F, Popov, E M

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