Search Results - "Lipkin, Martin"

The Role of Vitamin D in Cancer Prevention by Garland, Cedric F, Garland, Frank C, Gorham, Edward D, Lipkin, Martin, Newmark, Harold, Mohr, Sharif B, Holick, Michael F

“…Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased…”
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Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms by Lamprecht, Sergio A, Lipkin, Martin

“…Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained…”
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Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2 by Velcich, Anna, Yang, WanCai, Heyer, Joerg, Fragale, Alessandra, Nicholas, Courtney, Viani, Stephanie, Kucherlapati, Raju, Lipkin, Martin, Yang, Kan, Augenlicht, Leonard

“…The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in…”
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Dietary Induction of Colonic Tumors in a Mouse Model of Sporadic Colon Cancer by KAN YANG, KURIHARA, Naoto, VELCICH, Anna, LIPKIN, Martin, AUGENLICHT, Leonard, KUNHUA FAN, NEWMARK, Harold, RIGAS, Basil, BANCROFT, Laura, CORNER, Georgia, LIVOTE, Elayne, LESSER, Martin, EDELMANN, Winfried

“…A defined rodent "new Western diet" (NWD), which recapitulates intake levels of nutrients that are major dietary risk factors for human colon cancer, induced…”
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Cox-2 expression, PGE₂ and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice by Gravaghi, Claudia, La Perle, Krista M.D, Ogrodwski, Paul, Kang, Jing X, Quimby, Fred, Lipkin, Martin, Lamprecht, Sergio A

“…There is great interest in the role of polyunsaturated fatty acids (PUFAs) in promoting (n-6 class) or inhibiting (n-3 class) inflammation. Mammalian cells are…”
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An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents by Kucherlapati, Melanie H, Lee, Kyeryoung, Nguyen, Andrew A, Clark, Alan B, Hou, Harry, Rosulek, Andrew, Li, Hua, Yang, Kan, Fan, Kunhua, Lipkin, Martin, Bronson, Roderick T, Jelicks, Linda, Kunkel, Thomas A, Kucherlapati, Raju, Edelmann, Winfried

“…Background & Aims Mutations in the DNA mismatch repair (MMR) gene MSH2 cause Lynch syndromes I and II and sporadic colorectal cancers. Msh2 null mice…”
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Interaction of Muc2 and Apc on Wnt Signaling and in Intestinal Tumorigenesis : Potential Role of Chronic Inflammation by KAN YANG, POPOVA, Natalia V, EDELMANN, Winfried, LIPKIN, Martin, AUGENLICHT, Leonard, VELCICH, Anna, WAN CAI YANG, LOZONSCHI, Ioanna, TADESSE, Selam, KENT, Scott, BANCROFT, Laura, MATISE, Ilze, CORMIER, Robert T, SCHERER, Stefan J

“…Somatic mutations of the adenomatous polyposis coli (APC) gene are initiating events in the majority of sporadic colon cancers. A common characteristic of such…”
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25-hydroxyvitamin D-1α-hydroxylase in normal and malignant colon tissue by Tangpricha, Vin, Flanagan, John N, Whitlatch, Lyman W, Tseng, Chi C, Chen, Tai C, Holt, Peter R, Lipkin, Martin S, Holick, Michael F

“…Vitamin D affects calcium metabolism and prevents proliferation of colon cells in vitro. In human beings the main circulating form of vitamin D is…”
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Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility by Yang, Guohze, Scherer, Stefan J., Shell, Scarlet S., Yang, Kan, Kim, Mimi, Lipkin, Martin, Kucherlapati, Raju, Kolodner, Richard D., Edelmann, Winfried

“…Mutations in DNA mismatch repair (MMR) genes cause hereditary nonpolyposis colorectal cancer (HNPCC), and MMR defects are associated with a significant…”
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An Msh2 point mutation uncouples DNA mismatch repair and apoptosis by LIN, Diana P, YUXUN WANG, UMAR, Asad, KUCHERLAPATI, Raju, LIPKIN, Martin, KUNKEL, Thomas A, EDELMANN, Winfried, SCHERER, Stefan J, CLARK, Alan B, KAN YANG, AVDIEVICH, Elena, BO JIN, WERLING, Uwe, PARRIS, Tchaiko, KURIHARA, Naoto

“…Mutations in the human DNA mismatch repair gene MSH2 are associated with hereditary nonpolyposis colorectal cancer as well as a significant proportion of…”
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Haploinsufficiency of Flap Endonuclease (Fen1) Leads to Rapid Tumor Progression by Kucherlapati, Melanie, Yang, Kan, Kuraguchi, Mari, Zhao, Jie, Lia, Maria, Heyer, Joerg, Kane, Michael F., Fan, Kunhua, Russell, Robert, Anthony M. C. Brown, Kneitz, Burkhard, Edelmann, Winfried, Kolodner, Richard D., Lipkin, Martin, Kucherlapati, Raju

“…Flap endonuclease (Fen1) is required for DNA replication and repair, and defects in the gene encoding Fen1 cause increased accumulation of mutations and genome…”
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Mbd4 Inactivation Increases C→T Transition Mutations and Promotes Gastrointestinal Tumor Formation by Wong, Edmund, Yang, Kan, Kuraguchi, Mari, Werling, Uwe, Avdievich, Elena, Fan, Kunhua, Fazzari, Melissa, Jin, Bo, Anthony M.C. Brown, Lipkin, Martin, Edelmann, Winfried

“…Mbd4 (methyl-CpG binding domain 4) is a novel mammalian repair enzyme that has been implicated biochemically in the repair of mismatched G-T residues at…”
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Dietary factors in human colorectal cancer by Lipkin, M, Reddy, B, Newmark, H, Lamprecht, S.A

“…Colorectal cancer is a significant cause of mortality in Western societies. The progression of the disease from normal colonic epithelium to the acquisition of…”
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Preclinical and Early Human Studies of Calcium and Colon Cancer Prevention by LIPKIN, MARTIN

“…ABSTRACT Colorectal cancer continues to be a major cause of tumor mortality in the United States and other countries; despite attempts to improve the screening…”
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Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis by BOOLBOL, S. K, DANNENBERG, A. J, BERTAGNOLLI, M. M, CHADBURN, A, MARTUCCI, C, GUO, X. J, RAMONETTI, J. T, ABREU-GORIS, M, NEWMARK, H. L, LIPKIN, M. L, DECOSSE, J. J

“…Inducible cyclooxygenase (Cox-2), also known as prostaglandin H synthase 2 (PGH-2) is a key enzyme in the formation of prostaglandins and thromboxanes. Cox-2…”
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Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon by Yang, Kan, Lamprecht, Sergio A., Liu, Yanhui, Shinozaki, Hiroharu, Fan, Kunhua, Leung, Denis, Newmark, Harold, Steele, Vernon E., Kelloff, Gary J., Lipkin, Martin

“…In this study we investigated the chemopreventive effects of quercetin and rutin when added to standard AIN-76A diet and fed to normal and azoxymethane…”
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Mutation in the mismatch repair gene Msh6 causes cancer susceptibility by Edelmann, W, Yang, K, Umar, A, Heyer, J, Lau, K, Fan, K, Liedtke, W, Cohen, P E, Kane, M F, Lipford, J R, Yu, N, Crouse, G F, Pollard, J W, Kunkel, T, Lipkin, M, Kolodner, R, Kucherlapati, R

“…Mice carrying a null mutation in the mismatch repair gene Msh6 were generated by gene targeting. Cells that were homozygous for the mutation did not produce…”
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Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon by Kucherlapati, Melanie H, Yang, Kan, Fan, Kunhua, Kuraguchi, Mari, Sonkin, Dmitriy, Rosulek, Andrew, Lipkin, Martin, Bronson, Roderick T, Aronow, Bruce J, Kucherlapati, Raju

“…To examine the role of Rb1 in gastrointestinal (GI) tumors, we generated mice with an Apc 1638N allele, Rb tm2brn floxed alleles, and a villin-cre transgene…”
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Effect of a Western-style diet fortified with increased calcium and vitamin D on mammary gland of C57BL/6 mice by Kurihara, Naoto, Fan, Kunhua, Thaler, Howard T, Yang, Kan, Lipkin, Martin

“…We previously reported hyperproliferation and hyperplasia in C57Bl/6 mouse mammary gland after feeding a Western-style diet (WD); these findings decreased…”
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Update of preclinical and human studies of calcium and colon cancer prevention by Lipkin, Martin

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