Search Results - "Lipicky, RJ"

Drug-Induced Torsades de Pointes and Implications for Drug Development by FENICHEL, ROBERT R., MALIK, MAREK, ANTZELEVITCH, CHARLES, SANGUINETTI, MICHAEL, RODEN, DAN M., PRIORI, SILVIA G., RUSKIN, JEREMY N., LIPICKY, RAYMOND J., CANTILENA, LOUIS R.

“…Torsades de pointes is a potentially lethal arrhythmia that occasionally appears as an adverse effect of pharmacotherapy. Recently developed understanding of…”
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Myonecrosis After Revascularization Procedures by Califf, Robert M., Abdelmeguid, Alaa E., Kuntz, Richard E., Popma, Jeffrey J., Davidson, Charles J., Cohen, Eric A., Kleiman, Neal S., Mahaffey, Kenneth W., Topol, Eric J., Pepine, Carl J., Lipicky, Ray J., Granger, Christopher B., Harrington, Robert A., Tardiff, Barbara E., Crenshaw, Brian S., Bauman, Robert P., Zuckerman, Bram D., Chaitman, Bernard R., Bittl, John A., Ohman, E.Magnus

“…The detection of elevated cardiac enzyme levels and the occurrence of electrocardiographic (ECG) abnormalities after revascularization procedures have been the…”
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Trough: peak ratio: the rationale behind the United States Food and Drug Administration recommendations by Lipicky, R J

“…TROUGH EFFECT: For most formulations of most antihypertensive drugs which are administered in a chronic multiple-dose regimen, one of the requirements for…”
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Metabolism of benzocaine during percutaneous absorption in the hairless guinea pig: acetylbenzocaine formation and activity by Kraeling, M E, Lipicky, R J, Bronaugh, R L

“…The effect of dose and enzymatic inhibition on the percutaneous absorption and metabolism of benzocaine was studied in vitro in the hairless guinea pig. At the…”
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A viewpoint on drugs that prolong the QT(c) interval by Lipicky, Raymond John

“…Whether or the prolongation of the QT interval is beneficial is discussed. While QT prolongation can be beneficial, the risks associated with pharmacologic QT…”
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Role of ABPM in clinical development of antihypertensive drugs by Lipicky, RJ, Stockbridge, N

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Assessment of antihypertensive activity in the regulatory setting by Myers, M G, Lipicky, R J

“…Before a new antihypertensive drug receives regulatory approval, it must demonstrate a significant blood pressure-lowering effect over its entire dosing…”
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Role of surrogate end points in the evaluation of drugs for heart failure by Lipicky, Raymond John, Packer, Milton

“…To be of clinical value in the treatment of heart failure, a drug must permit patients either to feel better or to live longer, or both. Yet, because the…”
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A viewpoint on drugs that prolong the QTc interval by LIPICKY, R. J

“…Insufficient evidence exists to suggest that prolongation of the QT interval corrected for heart rate (QTc) is necessarily beneficial. In all but…”
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Short and long-acting oral nitrates for stable angina pectoris by THADANI, U, LIPICKY, R. J

“…Nitroglycerin (NTG) spray and sublingual tablets rapidly relieve an established attack of angina, and their infrequent use is not associated with the…”
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Ointments and transdermal nitroglycerin patches for stable angina pectoris by THADANI, U, LIPICKY, R. J

“…Nitroglycerin (NTG) ointment is used for the prophylaxis against angina pectoris, but there are no data to support its effectiveness during long-term therapy…”
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On the trough-to-peak ratio of drug effect in antihypertensive trials by Fenichel, Robert R., Lipicky, Raymond J.

“…Blood pressure in hypertensives (treated or untreated) varies over the course of the day, and, although animal models and human intervention studies have…”
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Testing for the Existence of a Desirable Dose Combination by H. M. James Hung, Chi, G. Y. H., Lipicky, R. J.

“…We consider the problem of studying several dose combinations of two drugs for a therapeutic endpoint in a multilevel factorial clinical trial. Two test…”
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Panel Discussion #1 by Myers, M

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Panel discussion #2 by Myers, Martin G., Lipicky, Raymond J., Uscinowicz, Tomas, Carruthers, S. George, White, William B.

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Determination of K(+)-channel relaxation times in squid axon membrane by Hodgkin-Huxley and by direct linear analysis by Fishman, H M, Lipicky, R J

“…An assumption in the use of the Hodgkin-Huxley (HH) formulation (A.L. Hodgkin and A.F. Huxley, J. Physiol. 117 (1952) 500) to extract kinetic parameters from…”
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Cable parameters, sodium, potassium, chloride, and water content, and potassium efflux in isolated external intercostal muscle of normal volunteers and patients with myotonia congenita by Lipicky, R J, Bryant, S H, Salmon, J H

“…In isolated fiber bundles of external intercostal muscle from each of 13 normal volunteers and each of 6 patients with myotonia congenita, some or all of the…”
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Effects of yohimbine on squid axons by Lipicky, R.J., Gilbert, D.L., Ehrenstein, G.

“…Yohimbine, an indolealkylamine alkaloid, reduces the amplitude of the sodium current in the squid giant axon. For doses that reduce sodium current amplitude by…”
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Sodium currents in human skeletal muscle fibers by DeCoursey, T E, Bryant, S H, Lipicky, R J

“…Sodium currents from human external intercostal muscle fibers were recorded using the Hille-Campbell voltage clamp method. Sodium currents are analyzed in…”
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Diphenylhydantoin Inhibition of Sodium Conductance in Squid Giant Axon by Lipicky, Raymond J., Gilbert, Daniel L., Stillman, Irving M.

“…Diphenylhydantoin, in concentrations of 5-50 μ M, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are…”
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