Overlap and divergence of neural circuits mediating distinct behavioral responses to sugar

How do neural circuits coordinate multiple behavioral responses to a single sensory cue? Here, we investigate how sweet taste drives appetitive behaviors in Drosophila, including feeding, locomotor suppression, spatial preference, and associative learning. We find that neural circuits mediating diff...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 43; no. 10; p. 114782
Main Authors:	Jacobs, Ruby V., Wang, Crystal X., Nguyen, Lam, Pruitt, Trinity J., Wang, Panxi, Lozada-Perdomo, Fiorella V., Deere, Julia U., Liphart, Hannah A., Devineni, Anita V.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 22-10-2024 Elsevier
Subjects:	bitter CP: Metabolism CP: Neuroscience Drosophila hunger neural circuit optogenetics sensory processing sugar taste neural circuit sensory processing CP: Neuroscience CP: Metabolism Drosophila taste optogenetics sugar bitter hunger
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Summary:	How do neural circuits coordinate multiple behavioral responses to a single sensory cue? Here, we investigate how sweet taste drives appetitive behaviors in Drosophila, including feeding, locomotor suppression, spatial preference, and associative learning. We find that neural circuits mediating different innate responses to sugar are partially overlapping and diverge at the second and third layers. Connectomic analyses reveal distinct subcircuits that mediate different behaviors. Connectome-based simulations of neuronal activity predict that second-order sugar neurons act synergistically to promote downstream activity and that bitter input overrides the sugar circuit through multiple pathways acting at third- and fourth-order neurons. Consistent with the latter prediction, optogenetic experiments suggest that bitter input inhibits third- and fourth-order sugar neurons to override the sugar pathway, whereas hunger and diet act earlier in the circuit to modulate behavior. Together, these studies provide insight into how circuits are organized to drive diverse behavioral responses to a single stimulus. [Display omitted] •Circuits for distinct sugar-evoked behaviors diverge at the second and third layers•Sugar interneurons likely act synergistically to promote circuit activity•Bitter input suppresses the sugar circuit through multiple pathways•Modulatory factors act at different sites in the sugar circuit to regulate behavior Sensory stimuli, such as the taste of sugar, can evoke diverse behavioral responses. Jacobs et al. show that circuits for different innate responses to sugar in Drosophila partially overlap and diverge at the second and third layers. Modulatory factors act at different sites in the sugar circuit to influence behavior.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2211-1247 2211-1247
DOI:	10.1016/j.celrep.2024.114782